Psychotic disorders Flashcards
Positive Symptoms of psychosis
Delusions, hallucinations, disorders of thought, agitation, aggression
Negative symptoms of psychosis
Affective flattening Diminished emotional expressiveness Alogia Avolition Apathy Anergia Asociality
Mood symptoms of psychosis
Depression anxiety, suicide
Dopamine Hypothesis - VERY BROAD OVERVIEW
Too much dopamine - treat with traditional dopaminergenic blockade
Schizophrenia DSM-5
Two or more of Delusions Hallucinations Disorganized Speech Grossly disorganized or catatonic behavior Negative symptoms
At least ONE positive symptom
At least 6 MONTHS
typical antispychotics - basic mechanism and problems
Dopaminergic blockade - The problem is that you suppress the basal ganglia, leading to a range of problems - Dystonia, Akathesis, and even parkinsonism
Atypical antipsychotics - advantage over typicals
Blockade is more specific - mesolimbic system only. Preservation of dopaminergic tone in other brain systems, including mesocortical and nigrostriatal
Atypical Antipsychotics - problems
Weight gain, high blood sugar, high triglycerades, long QTc - leading to Diabetes
Depot Antipsychotics
Advantage - automatic compliance
Disadvantage - side effects are long-lasting.
Brief Psychotic disorder
Lasts from 1 day to 1 month, otherwise the same as schizophrenia
Schizophreniform disorder
Same as schizophrenia, lasting 1-6 months
Delusional Disorder
Hallucination, disorganized thought/behavior, less responsive to meds. Age >40, women > men
Schizoaffective Disorder
Schizophrenia Symptoms AND a mood component - mania or depression. The mood symptoms are the characterizing factor.
Schizoid disorder
Excessive detachment from social relationships - restricted range of emotion. NOT UNCOMFORTABLE
Schizotypal Disorder
Excessive DISCOMFORT in close relationships, accompanied by perceptual distortions / eccentricities.
