Psychotic Disorders

Question 1

Dopaminergic pathway associated with negative symptoms of schizophrenia

Answer 1

Mesocortical pathway

Question 2

Disorder associated with impairment of excitation-inhibitory balance due to altered NMDA signaling

Answer 2

Schizophrenia

Question 3

Most common dopamine subtype targeted in schizophrenia

Answer 3

D2

Question 4

Most commonly used substance among patients with schizophrenia

Answer 4

Nicotine

Question 5

Smoking inc/dec levels of antipsychotic

Answer 5

Decrease, due to increasing metabolism

Question 6

T/F. Being female is associated with a better prognosis for schizophrenia.

Answer 6

True

Question 7

Disorder where affected person thinks his genitals are regressing or retracting into his body, which will lead to subsequent death

Answer 7

Koro disorder

Question 8

Syndrome found amongst the Cambodian population where individuals perceive wind-like substances as causing distress, anxiety, palpitations, and other autonomic symptoms

Answer 8

Khyâl attacks or khyâl cap

Question 9

Prevalence rate of monozygotic twin of schizophrenia whose twin has this disorder?

Answer 9

47%

Question 10

Prevalence of schizophrenia in general population?

Answer 10

1%

Question 11

Low platelet monoamine oxidase levels are associated with the diagnosis of ____

Answer 11

schizophrenia

Question 12

Peak age of onset of schizophrenia in women

Answer 12

25-35 years old

Question 13

On head imaging patients with schizophrenia can be seen with increased/decreased ventricular size

Answer 13

Increased

Question 14

ECT in pregnancy: Fetal heart rate must be checked before and after each session when gestational age is over ___ weeks.

Answer 14

10

Question 15

Patients with schizophrenia have increased/decreased volume of the hippocampus, parahippocampal gyrus, and amygdala on imaging

Answer 15

decreased

Question 16

Understimulation of NMDA receptors by glutamate is thought to cause this psychiatric symptom

Answer 16

Psychosis

Question 17

More studies are being done with the association of negative symptoms for schizophrenia and this neurotransmitter

Answer 17

Glycine

Question 18

The hippocampus, amygdala, and parahippocampal gyrus are reduced/enlarged in size in patients with schizophrenia

Answer 18

REDUCED

Question 19

Schizoaffective disorder requires __ weeks of psychotic symptoms in the absence of mood symptoms

Answer 19

2

Question 20

Kraeplin’s 4 A’s

Answer 20

Associations, Affect, Autism, and ambivalence

Question 21

The dopamine hypothesis of schizophrenia indicates that higher amphetamine provoked dopamine release indicates better/worsening psychotic symptoms

Answer 21

worsening

Question 22

Pt brought to outpatient clinic for first eval of schizophrenia. When should they follow up after being prescribed antipsychotic?

Answer 22

1-3 weeks.

Question 23

Malaysian cultural syndrome that begins with sudden rampage (suicidal/homicidal) and ends in exhaustion and amnesia

Answer 23

Amok

Question 24

Delusional fear displayed by Native American Indians of being turned into a cannibal through possession by a supernatural monster

Answer 24

Wihtigo

Question 25

Cultural syndrome that occurs to female Eskimos of northern Greenland. It involves anxiety, depression, confusion, depersonalization, and derealization, ending in stuporous sleep and amnesia

Answer 25

Piblokto

Question 26

A sensation of an altered state in body organs without any special receptor apparatus to explain the sensation

Answer 26

Cenesthetic hallucination

Question 27

Late onset schizophrenia tends to occur after age ___, in this gender: _____

Answer 27

45, female

Question 28

fMRI has shown decreased blood flow to the ____ lobes in schizophrenia

Answer 28

Occipital

Question 29

T/F: One can see increased basal ganglia nuclei on an MRI for a patient with schizophrenia

Answer 29

True

Question 30

Recent meta-analyses found that first-generation immigrants have a ____ times increased risk of a brief psychotic disorder relative to the general public.

Answer 30

2

Question 31

Pt w/ Chrohn's Dz with sx of Wernicke's encephalopathy. Next step?

Answer 31

Start thiamine 200 mg TID parenterally | DO NOT obtain labs to confirm deficiency, must have prompt treatment

Question 32

Concordance rate of schizophrenia in dizygotic twins

Answer 32

14%

Question 33

Risk of schizophrenia in a child who has one parent with schizophrenia

Answer 33

10%

Question 34

Slowed thought processes; a condition seen in schizophrenia and in Parkinsonism

Answer 34

Bradyphrenia

Question 35

A family history of psychosis, younger age of onset of seizures, borderline intellectual function, and presence of complex partial seizures are correlated with the development of chronic interictal ___ in patients with epilepsy.

Answer 35

psychosis

Question 36

It is theorized that the α7 ____ _____ receptor (α7 nAChR) dysfunction is a primary driver of cognitive dysfunction in schizophrenia patients.

Answer 36

Nicotinic Acetylcholine

Question 37

Approximate annual relapse rate for patients with schizophrenia who are adherent in taking antipsychotics

Answer 37

30-40%

Question 38

This anatomical structure is associated with auditory hallucinations in patients with schizophrenia

Answer 38

Arcuate fasciculus

Question 39

Percentage of pts with schizophrenia who die by suicide

Answer 39

5-10%

Question 40

Percentage of pts with schizophrenia who attempt suicide

Answer 40

20%