Neurology Flashcards
Symptoms of cerebellar infarct/hemorrhage (4)
Dizziness, inability to walk, gaze palsy w/o hemiplegia
Juvenile Huntington’s dz is ______ dominant from the father
Autosomal
Med to start on patient with TIA and hypercholesterolemia hx
Aspirin (get that anti-platelet therapy started!)
CT Scan findings for Huntington’s
Diffuse cerebral atrophy
Healthcare worker w/ anisocoria (9 mm dilated) and normal extraocular motility; etiology is usually driven by ____
pharmacologic mydriatics
Most common non-heritable genetic cause of intellectual disability
Trisomy 21
If elderly pt on oral rivastigmine has intolerable GI sx (N/V), what would be next step?
Switch to transdermal patch of rivastigmine
Felbamate (AED) causes these adverse side effects which leads to it being a last resort med (2)
Liver failure, aplastic anemia
Those with vascular NCD usually sees issues with _____ function earliest in dz course
Executive
Klein-Levin Syndrome Sx (3)
hypersomnia, aggressive, overly sexual behavior
Tx for Klein-Levine Syndrome
Modafanil for sleep-wake d/o
T/F: All of the cholinesterase inhibitors have been found to be equally effective in the treatment of NCD due to Alzheimer’s disease
True
T/F: Rivastigmine is hepatically metabolized
False. Metabolized through kidney
T/F: Due to drug-drug interactions, galantamine should not be prescribed concurrently with memantine
False. Galantamin + Memantine combo is the SOC for AD.
MOCA examines this with trails B, cube/clock drawing
Executive Functioning
Repeating 5 words and recalling them after a short period of time tests _____
delayed recall
Naming as many words that start with a specific letter tests ____
language
Serial 7’s tests and spelling world backwards tests this
Attention
Defining similarities between objects (orange-apple) tests this
Abstraction
Drug that can reduce functional impairment in ALS pt
Edaravone
Lambert Eaton dx is most commonly associated with this type of cancer
small lung cell
What tends to be spared in Lambert Eaton syndrome as opposed to myasthenia gravis?
Cranial nerves (with an exception of a mild ptosis)
Most common neuropathy associated with HIV
Distal symmetric axonal polyneuropathy
When is neonatal cerebral myelination completed?
2 years postpartum
Regions of the brain most affected by HIV dementia (2)
Basal ganglia and hippocampus
Hyperphosphorylated tau protein in the hippocampus is most associated with this dx
Alzheimer’s Disease
Dx with 14-3-3 protein or tau in cerebrospinal fluid (CSF)
Creutzfeldt-Jakob disease
Brain MRI Imaging findings for Creutzfeldt-Jakob dz
hyperintensities on FLAIR and T2 weighted images in the cortex, corpus striatum, and putamen.
Hoover’s sign
no counterpressure felt in the physician’s hand under the affected leg while the patient attempts to lift the unaffected leg (psychogenic origin of sx)
Syndrome associated with mutation of MECP2 gene on X chromosome
Rett Syndrome
Pt with DM, HTN presenting with 3rd cranial nerve palsy with pupils being spared. Likely dx?
Cranial nerve III ischemia
T/F: Posterior communicating artery aneurysm would affect pupillary fibers first.
True
Syndrome with variable quadriparesis due to compression of the corticospinal and spinothalamic tracts. Upper extremities are more severely involved than the lower extremities, and there is some degree of sensory sparing.
Central Cord Syndrome
Artery that can be found in the anterior median grove of the pons
Basilar
Areas of the brain implicated in stimulating urges in patients with pathological gambling (2)
Ventral Striatum, and ventromedial prefrontal cortex
Initial tx for polymyositis
High dose oral corticosteroids
When is IVIG considered for polymyositis?
If trial with oral steroids is not effective
Stiff person syndrome is associated with these antibodies
Anti- glutamic acid decarboxylase (GAD) antibodies
Stiff person syndrome has a significant association with this medical condition
insulin-dependent Diabetes mellitus
In comparison to adolescents with substance use disorders, those with internet addiction have low/high harm avoidance
High
Neurocognitive disorder that presents with fluctuating levels of cognitive function
Neurocognitive disorder with Lewy Bodies