psychotic disorder

Question 1

All antipsychotic drugs can produce _____ syndromes. How do you tx it?

Answer 1

parkinsonium
- they compete with DA for postsynaptic receptors DR2

tx with antimuscarinics

*note: 2nd gen (clozapine) atypical antipsychotics have little-no parkinsonium syndromes bind more to 5HT2A R

Question 2

Association cortex has DLPFC, which is important in ______. Hyperactivity of DLPFC → _______

Answer 2

executive functioning

Cognitive insufficiency in schizophrenia

Question 3

Medial temporal lobe and hippocampus plays roles in integrating multimodal sensory info for _______.
Hippocampal dysfunction →

Answer 3

Storage and retrieval of memory

synaptic organization change → positive symptoms (delusions, hallucinations)

Question 4

Thalamus is a gateway for ____ of _____ information.

Decrease in thalamic vol/dysfxn of medial dorsal nucleus of thalamus →______

Answer 4

Cortical processing, incoming sensory

impairment in schizophrenia

Question 5

Basal ganglia is important for _______ from motor cortex.

Change in volume of caudate and other nuclei → ____

Answer 5

integration of input from motor cortex

schizophrenia

Question 6

Cocaine- amphetamine + Levadopa aggravate or produce de novo ______

Answer 6

Schizophrenia

Question 7

5HT2A receptors are blocked by atypical agents will result in (select) Increase/Decrease DA release, resulting in alleviation of (positive/negative) symptoms of shizophrenia.

Answer 7

Increase DA

alleviate negative symptoms

Question 8

Which drug class can be used to tx akathisia + pseudoparkinsonium?

Answer 8

Antichoninergics (amantadine)

Question 9

Clozapine can result in which malignant syndrome?

Answer 9

Neuroepileptic malignant syndrome
- Effective in pts who are refractory to other drugs

(diff cause from malignant hyperthermia, but tx both with dantrolene)