Limbic system - Hippocampus - amyg

Question 1

Declarative memory

- lesions where causes impairment in dec. mem?

Answer 1

ability to recollect events or facts that have a specfic temporal and spatial context.

• Hippocampus

Question 2

Procedural memory

Answer 2

ability to learn new motor skills

Question 3

what kind of memory is affectd by lesions in frontal cortex?

Answer 3

short term memory

Working memory
- lasts sec-min

Question 4

_____ is the site for long term memory storage.

Hippocampus is important in formation and consolidation of _______ memory

Answer 4

neocortex

long term declarative
- which is stored in neocortex

Question 5

pt HM has had medial temporal lobe resection. He has problems in ______ memory, but not _____ memory

Answer 5

declarative memory,
procedural memory (a-ok)

(aka had his hippocampus removed)

Question 6

____ is imp in form of declarative memory.

_____ is imp in formation of procedural memory

Answer 6

hippocampus

Cerebellum/striatum/frontal cortex
- proc. mem: ability to learn new motor skills

Question 7

How do hippocampal synapses undergo LTP?

Answer 7

Trisynaptic circuit

Entorhinal cortex → (perforant path) → dentate gyrus → (mossy fibers) → CA3→ (Shaeffer cells) → CA1 → (feedbacks/autoassociation on C3) → entorhinal cortex

(Both CA1 and CA3 can undergo LTP)
- repeated stim. of CA3 or CA1 neurons lead to LTP
(both loc on Hippocampus)

Failure to maintain LTP in the hippocampus can be due to AB protein deposition

Question 8

Kluver Bucy syndrome

Answer 8

removal of amygdala -

important in expression of emotion.

Question 9

Conditioned flavor aversion (CFA)

Answer 9

eat food → widespread ACh spread throughout brain → insular cortex (taste response) → (NMDA P) → Amygdala

(if antagonists are perfused to insular cortex = no food aversion)

Question 10

(select ips/contralateral)

Projections from the Cerebellum are _____, but it affects ________

Answer 10

contralateral,

presents as ips

Question 11

Papez (memory) circuit vs Amygdala (emotion) circuit

Answer 11

Papez:
hippocampus → fornix →mamillary bodies → ant. nucleus of thalamus → cingulate gyrus (cortex)

Amygdala:
amgydala → stria terminalis → steptal area or hypothalamus → amygdala