psychosis + schitzophrenia Flashcards

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1
Q

what is psychosis?

A

Psychosis refers to a group of symptoms that impairs perception of reality

-hallucinations
-disorganised thought
-delusion

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2
Q

what is a hallucination?

A

-a perception which occurs in the absence of an external stimulus
-has the same qualities as a normal perception
-is not subject to conscious manipulation
-can occur in any sensory modality

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3
Q

what is passivity phenomena?

A

-phenomena where they think someone is controlling what they do, their emotions or thoughts
-they made me think/ do/ feel this

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4
Q

what is thought interference?

A

-thought interference refers to thought broadcasting, insertion, blocking or withdrawal

Thought insertion - “There are thoughts being put into my head that don’t belong to me - I haven’t thought them.”

Thought withdrawal - “They can extract the information from me using the internet, they take my thoughts out of my head”

Thought broadcasting - “It’s like everyone can know what I am thinking - my sky dish is beaming what I am thinking to the neighbours, they all know!”

Thought blocking - “It’s like I get halfway through thinking something and the thoughts just dry up, and I can’t think anything for a while.”

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5
Q

what is loss of insight?

A

you can think you’re fine and everything is normal, don’t realise that you are ill

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6
Q

what are delusions?

A

A firm fixed belief based on inadequate grounds

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7
Q

presentation of hebephrenic schitzophrenia?

A

-affective symptoms are prominent delusions and hallucinations, feeling and fragmentary, behaviour irresponsible and unpredictable, and mannerisms common

-The mood is shallow and inappropriate, thought is disorganised, and speech is incoherent

-Early negative symptoms

-a lot of disorderd speech/thought

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8
Q

what are examples of negative symptoms?

A
  • Reduced amount of speech
  • Reduced motivation/drive
  • Reduced interest/ pleasure
  • Reduced social interactions
  • Blunting of affect
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9
Q

when are negative symptoms typically seen?

A

during the predromal phase

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10
Q

what are examples of positive symptoms?

A
  • Hallucinations
  • Delusions
  • Passivity Phenomena
  • Disorder of the form of thought
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11
Q

what is the dopamine theory regarding psychosis?

A

Dopamine dysregulation causes psychosis

Dopamine regulates salience of external events and internal representations

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12
Q

Dopamine theory- what causes positive schitzophrenia symptoms?

A

subcortical dopamine hyperactivity

(mesolimbic pathway VTa> Nucleus accumbens)

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13
Q

dopamine theory- what causes negative schitzophrenia symptoms?

A

frontal dopamine hypoactivity

(mesocortical pathway VTA> frontal cortex)

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14
Q

risks for developing schitzophrenia?

A

it has a polygenetic inheritence

RISKS:
-Viral illness in 2nd trimester in utero
-Long term cannabis use
-FH

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15
Q

what can make schitzophrenia worse?

A

amphetamines

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16
Q

what changes are made to the brain structure in schitzophrenia?

A

-enlarged ventricles
-reduced fronto temporal volume
-reduced frontal lobe grey matter
-Reduced activation of prefrontal areas on specific tasks
-Poor neuronal activity

17
Q

presentation of catatonic scitzophrenia?

A

Movement disorder predominates, alternating between stupor and hyperkinesis

Automatic obedience, posturing and waxy flexibility

18
Q

what is used to treat positive symptoms?

A

antipsychotics

19
Q

what is a long prodromal stage associated with?

A

-poor prognosis

20
Q

what is an acute schitzoprenic episode like?

A

-this is usually their first psychotic episode

-more positive symptoms dominate

21
Q

how does chronic schitzophrenia typically present?

A

negative symptoms dominate

22
Q

what is a self referential experience?

A

The sense than external events are connected to oneself in some way ​

TV/Radio are transmitting signals aimed at me

23
Q

what is knights move thinking?

A

AKA loosening of associations

unexpected illogical connections between ideas

-will jump from idea to idea with increasingly more fragmented connections

24
Q

what is flight of ideas?

A

-quick erratic speech where the person is jumping from ideas
-no apparent association between the ideas

25
Q

what are neologisms?

A

-made up words

26
Q

what is verbigerism?

A

AKA word salad

words dont match up AKA jesus leather

27
Q

what is circumferentially?

A

-when they work around the point and eventually get back to it

28
Q

what is tangiability?

A

-when they go on a tangent and don’t get back to the point

29
Q

managment of scitzophrenia?

A

CBT

1st= 2nd generation antipsychotic drug e.g. olanzapine, quetiapine, risperidone, paliperidone, lurasidone, assess over 2-3 weeks

2nd= try a different 2nd generation antipsychotic or switch to a 1st generation

3rd= check diagnosis, consider psychological input, optimise social supports, check compliance (consider depot?)

4th= consider combining two antipsychotics, consider clozapine

30
Q

examples of second generation anti psychotics?

A

-olanzapine
-risperidone
-clozapine
-quetiapine
-paliperidone
-lurasidone

31
Q

examples of first generation anti psychotics?

A

-Chlorpromazine
-Haloperidol
-Zuclopenthixol
-Flupentixol
-Trifluoperazine
-Prochlorperazine

32
Q

SE of dopamine (D2) antagonists?

A

-extrapyramidal SE
-hyperprolactinaemia

33
Q

SE of histamine receptor antagonists?

A

-weight gain
- sedation

34
Q

SE of muscarinic receptor antagonists?

A

-anticholinergic effects (dry mouth, sedation, constipation)

35
Q

SE of adrenoceptor receptor antagonists?

A

-hypotension

36
Q

what is associated with poor prognosis of scitzophrenia?

A

-long predromal phase
-low IQ
-Strong family history
-Lack of obvious precipetent