Psychosis and Schizophrenia Flashcards
What are positive symptoms of Pyschosis and Schizophrenia?
Delusions, hallucinations, disorganisation
What are negative symptoms of Pyschosis and Schizophrenia?
Social withdrawal, neglect, poor hygiene
What class of drugs are 1st Gen Antipsychotics?
Phenothiazines
Give 3 examples of Group 1 1st Gen Antipsychotics and their effects on sedation, muscaraninic and extra pyramidal side effects?
Chlorpromazine, Levomepromazine, Promazine
Most Sedation
Moderate Antimuscarinic and EPSEs
Give an example of a Group 2 1st Gen Antipsychotics and their effects on sedation and extra pyramidal side effects?
Pericycazine
Moderate Sedation
Least EPSEs
Give 3 examples of Group 3 1st Gen Antipsychotics and their effects on sedation and extra pyramidal side effects?
Fluphenazine, Prochlorperazine and Trifluoperazine
Moderate Sedation
High EPSEs (especially not suitable for PD patients)
Why are Antipsychotics not suitable for PD patients?
Antipsychotics reduce dopamine in PD patients who already have low dopamine levels.
What are examples of 2nd Gen Antipsychotics?
Amisulpride
Ariprazole
Clozapine
Olanzapine
Quetiapine
Risperidone
Which Antipsychotics cause hyperglycaemia?
Clozapine
Risperidone
Olanzapine
Quetiapine
(CiROQ)
Which Antipsychotics cause hypotension?
Clozapine and Quetiapine
Which Antipsychotics cause weight gain?
Clozapine and Olanzapine
How do you treat Neuroleptic Malignant Syndrome caused by Antipsychotics?
Stop Treatment
Treat with Bromocriptine
Should resolve in 5-7 days
Which Antipsychotics are most likely to cause QT prolongation?
Pimozide and Haloperidol
What is the Weight monitoring required for Antispychotics?
Weekly for the first 6 weeks
At 12 weeks
At 1 year
Then Yearly
What is the fasting blood glucose, HbA1C and blood lipid concentration monitoring requirements for Antispychotics?
At the start
At 12 weeks
1 Year
Then yearly
What are the blood pressure monitoring requirements for Antipyschotics?
At the start
At 12 weeks
1 Year
Then yearly
When does ECG need to be monitored for Antipsychotics?
Berfore initiation
How often do FBC, U&Es and LFTs need to be monitored for Antipsychotics?
Start then yearly
When can Clozapine be used for Resistant Schizophrenia?
Only when 2 or more antipyschotics including 2nd Gen has been used for 6-8 weeks each.
How often do leucocyte and differential blood count need to be monitored on Clozapine?
Weekly for 8 weeks
Then every 2 weeks for 1 year
Then monthly until one month after last dose
What are 3 serious side effects of Clozapine?
1.Myocarditis and Cardiomyopathy
REPORT and STOP ON TACHYCARDIA
2.Agranulocytes and Neutropenia
Monitor leucocyte and differential blood counts
3.Gastrointestinal Disturbances
REPORT and STOP ON CONSTIPATION
- could be a sign of intestinal block
