Parkinson's Disease Flashcards
What is the treatment for PD patients whose motor symptoms decrease their quality of life?
Levodopa + Carbidopa / Benserazide
What are the 3 treatments for PD patients whose motor symptoms do not decrease their quality of life?
Levodopa
Non-ergot-derived dopamine receptor
Monoamine-oxidase-B inhibitors
What is the function of Carbidopa/Benserazide?
To prevent the breakdown of levodopa before it crosses into the brain
What are the side effects of Levodopa?
Impulse disorders such as:
Pathological Gambling
Binge Eating
Hypersexuality
Sudden Onset of Sleep (Treat with Modafinil)
Red Urine
What are 3 examples of Non-Ergot-Derived Dopamine-Receptor?
Pramipexole
Ropinirole
Rotigotine
What are side effects of Non-Ergot-Derived Dopamine-recpetors?
Impulse Disorders
Sudden onset of sleep
Hypotension
What are 2 examples of monoamine-Oxidase-B inhibitors (MAO-B)
Rasagiline
Selegiline
Which drug does MAO-B inhibitors interact with to cause hypertension crisis?
Phenylephrine
What are 2 examples of COMT inhbitors
Entacapone or Tolcapone
What colour can entacapone cause urine to turn?
Red-Brown
Which type of patients should Tolcapone be avoided in and why?
Tolcapone is hepatoxic = increased sympathetic side effects = increase in CVD events
When should ergot-derived dopamine receptor agonists be used?
When symptoms are not adequately controlled with non-ergot-derived dopamine receptor agonist as an adjuct to levodopa
What are 2 examples of ergot-derived dopamine receptor agonist?
Bromocriptine
Cabergoline
What are side effects of ergot-derived dopamine receptor agonists?
Pulmonary reactions: Report SOB, chest pain, cough
Pericardial reactions: Chest pain
What should be the first and second line treatments for nocturnal akinesia?
Levodopa or oral dopamine-receptor agonists (1st LINE)
Rotigotine (2nd LINE)
