Psychopharmacology Flashcards

1
Q

Antidepressants indications for what? Selection based on? Delay of how many weeks after therapeutic dose is achieved before symptoms improve? If no improvement after at least 2 months and adequate dose, do what?

A

Depression, OCD, GAD, panic disorder
Past hx of response, SE profile and coexisting medical conditions
3-6 weeks
Switch to another antidepressant

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2
Q

Classification of antidepressants? E.g. of other antidepressants?

A

Tricyclics
MAOIs
SSRIs
Others= duloxetine, reboxetine, mianserin, mirtazapine, trazadone, venlafaxine

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3
Q

1st line tx of depression? Next steps?

A

SSRI e.g. sertraline
Another SSRI/ another class
Combine/ adjunctive agent- vitamins, thyroid hormone, antipsychotics

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4
Q

E.g. of tricyclics? Also what what? For OCD? Most and least toxic? Action? SEs?

A

Amitriptyline, imipramine, lofepramine, neuropathic pain
Clomipramine
Dothiepine
Lofepramine
Inhibit reuptake of serotonin and NAD
Based on receptor type:
Antihistaminic- sedation+ weight gain
Anticholinergic- dry mouth, eyes, constipation, urinary retention
Antiadrenergic- postural hypotension, sedation, sexual dysfunction
Prolonged QT int, ST depression–> yearly ECG recommended

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5
Q

E.g. MAOIs? MAOIs effective in what? Action? SEs?

A
Phenelzine, tranylcypromine
Atypical depression (mood-reactivity, over-eating, over-sleeping)
Inhibits enzyme that degrades MA- dopamine, NA, AD, serotonin

Dangerous- hypertensive crisis (when taken with tyramine-rich foods/ sympathomimetics), serotonin syndrome, postural hypotension, weight gain, dry mouth, sedation, sexual dysfunction and sleep disturbance

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6
Q

When might serotonin syndrome occur? Symptoms? How avoided?

A

MAOI+ meds that increase serotonin/ have sympathomimetic actions (SSRI)
NM abnormalities, altered mental state, AN dysfunction- abdo pain, diarrhoea, sweats, tachycardia, nystagmus, myoclonus, irritability, delirium
Can lead to hyperpyrexia, CV shock+ death
Wait 2 weeks before switching from SSRI–> MAOI, fluoxetine (5 weeks)

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7
Q

E.g. of SSRIs? Younger people given what? Sertraline for who? Duloxetine prescribed in what also? Need to be on for how long? Action? SEs? Low risk of? First week, increased what? Recommend taking when?

A
Fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram
Fluoxetine 
Older people 
Non mental health issues 
6 months--> symptom resolution
Block presynaptic serotonin reuptake
GI upset, sexual dysfunction, anxiety
Cardiotoxicity
Suicidality/ unusual changes in behaviour
1st thing in the morning
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8
Q

E.g. of NaSSA? Action? Leads to what?

A

Mirtazapine
Blocks alpha receptors to increase monoamines
Weight gain and sedation/ drowsiness

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9
Q

E.g. of SNRIs? SEs? Venlafaxine can cause what? Action? NARI?

A
Venlafaxine, duloxetine
Similar to SSRIs, also increased BP and HR
Discontinuation symptoms
Serotonin and NAD reuptake inhibitor
Robxetine- NAD reuptake inhibitor
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10
Q

Mood stabilisers long-term tx for what? If patient with bipolar I has had what? Or if patient with bipolar II has what?

A

Bipolar
2/more acute episodes
Significant functional impairment, risk of suicide/ frequent episodes

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11
Q

E.g. mood stabilisers? Lithium also for what? Choice based on? What is monitored carefully?

A

Lithium, carbamazepine, sodium valproate, lamotrigine
Atypical- quetiapine, olanzapine, aripiprazole
Tx resistant depression
Previous txs, relative risk, manic vs depressive relapse, physical RFs- renal disease, obesity, diabetes
Preference and history of adherence

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12
Q

Response to lithium monotherapy how long? Often administered how? Effective against what? Compliant patients show a reduction in what? Combined with antipsychotic in the tx of what? Single dose associated with what?

A

6-10 days
In combination with antipsychotic for faster symptom relief
Manic, depressive, mixed relapse and suicidal behaviours
Suicidal behaviour
Mania–> acute symptom relief
Higher peaks in lithium levels–> SEs and deeper troughs–> higher likelihood of breakthrough symptoms

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13
Q

After starting lithium, should be checked after how long, then how often? In elderly/ impaired renal function patients, after how many days?

A

7 days
7 days after every dose change until desired level reached
10-12 days, time to steady-state increases

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14
Q

SEs of lithium? Organs needing monitoring? Severe toxicity leads to what? Therapeutic level? Toxicity symptoms? What level is an emergency?

A

Diarrhoea, frequent urination, hair loss, increased thirst, nausea, swelling, tremor, weight gain
Kidneys, parathyroid, thyroid- tests before tx
Encephalopathy, arrhythmias
0.8-1mmol/L
Tremor, nausea, diarrhoea, blurry vision–> unsteady, slurred speech, muscle twitches, weakness, confusion
2.0mmol/L–> delirium, arrhythmias

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15
Q

Interactions of lithium? Blood levels when? Mineral checked yearly? Kidney function and thyroid tests?

A

ARBs, ACEis, diuretics, NSAIDs
5 days after dosage change, new meds impacting lithium levels added/ discontinued
Calcium–> hypoparathyroidism
Beginning of tx, regularly during, if any symptoms become evident
Frequently and at least every 6 months

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16
Q

What is common co-morbid symptom with many psych illnesses? What is generally short-term tx until underlying better treated? E.g.?

A

Anxiety
Anxiolytics
Benzodiazepine- diazepam, lorazepam
Hypnotic- temazepam, zopiclone

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17
Q

Psychostimulants work how? E.g.? Indication? SEs?

A

Increase release and block reuptake of dopamine and NAD
Methylphenidate, modafinil, atomoxetine
ADHD, narcolepsy
Restlessness, insomnia, poor appetite, dizziness, tremor, palpitations, cardiac arrhythmias

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18
Q

Antipsychotics tx for what? To reduce what symptoms?

A

Schizophrenia, acute mania symptoms, psychotic symptoms, schizoaffective disorder, mood stabilisation, delirium, psychotic depression
Hallucinations, delusions, agitation, psychomotor excitement

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19
Q

Mode of action of antipsychotics?

A

DA theory of schizophrenia- overstimulation of postsynaptic D2 receptor in limbic system
Reformulation of DA theory- overactivity of mesolimbic dopaminergic activity in the frontal cortex–> -ve symptoms and cognitive impairment

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20
Q

1st generation/ typical APs against what? Atypical/ 2nd generation?

A

+ve symptoms, block D2 receptor/ EPSE
H1 and M1 receptor/ sedation+ anticholinergic effect

+ve and -ve symptoms, reduce D2 receptor potency
High affinity D3, D4 and 5HT
Less EPSE and hyperprolactinaemia

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21
Q

E.g. typical APs? Atypical? Clozapine for what?

A

Chorpromazine, haloperidol

Risperidone- depot, paliperidone= metabolite of risperidone
Olanzapine
Quetiapine
Aripiprazole
Clozapine- tablet–> tx resistant schizophrenia

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22
Q

Antidopaminergic SEs of APs? Antiadrenergic?

A

Acute dystonia, akathisia, Parkinsonism, tardive dyskinesia

Sedation, postural hypotension, inhibition of ejaculation

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23
Q

Anticholinergic SEs of APs? Other effects?

A

Dry mouth, reduce sweating, urinary retention, constipation, blurred vision
Arrhythmias, metabolic syndrome- dyslipidaemia amenorrhoea, galactorrhoea, hypothermia

24
Q

Symptoms of tardive dyskinesia? Tx?

A

Involuntary, repetitive purposeless movements, most common= perioral movements- tongue, lips and jaw
Increased by stress
Review hx, identify cause, reduce agent, change to atypical if possible

25
Akathisia caused by what? Feeling of what? Tx?
``` APs, ADs, anxiolytics Inner restlessness-LL, trunk Movement, pacing and restless High dose of high potency antipsychotics Reduce dose if possible, propanolol, benzodiazepines ```
26
Symptoms of acute dystonic reaction? Onset? Affects? Lasts? Tx?
``` Sustained painful muscular spasm, twisted abnormal postures Within 48 hours- 5 days Neck, tongue, jaw Minutes-hours Anticholinergic agent- IM injection ```
27
Symptoms of neuroleptic malignant syndrome? Tx?
Severe muscule rigidity, fever, altered mental state, AN instability, elevated WBC, CPK and LFTs Diazepam- muscle stiffness Dantrolen- malignant hyperthermia Bromocryptine- dopamine agonist
28
Why do we need the MHA?
Patients with mental disorder may lose insight and refuse to be assessed/ treatment: psychosis May lose capacity to make judgement for tx: dementia May be at risk- to themselves/ others
29
Informal admission have same rights and freedoms as who? Civil sections of MHA? Forensic sections?
Any other hospital patients Section 2,3,4 and 5 Section 37, 41- committed criminal offence
30
How many needed for MHA assessment?
3- 2 doctors, 1 psychiatrist 3 years training--> section 12 approved, 1 AMHP
31
Conditions for detention under MHA?
Suffering from mental disorder Detained in interests of patients own health/ safety or other persons Nature/ degree warrants the detention of the patient in a hospital- informal/ community assessment not appropriate
32
When is informal admission not appropriate? E.g. of risk to self/ others?
Refuse admission and/ or tx Does not have capacity to consent for admission and/or tx Self-harm/ suicide, self-neglect, further deterioration, vulnerability/ exploitation Aggression, neglect of minor e.g. children
33
3 important sections?
Section 2- assessment Section 3- admission for tx Section 5(2)- doctor's holding power for detention of patients who are already voluntary patients in hospital
34
Duration of section 2? Cannot be what? If continued detention needed, what used? Conditions for detention? What can be given?
28 days Renewed or extended Section 3 Suffering from a mental disorder that warrants detention for assessment Interests of his own health/ safety/ protection of other persons Informal admission= not appropriate Treatment- during/ following the assessment
35
Aim of section 3? Duration? May be what?
To detain someone in hospital for tx Up to 6 months initially Renewed for a further 6 months and then for a year at a time
36
Aim of section 5(2)? Can be/ can't be what ward? Duration? Can't be what? If continued detention required, then what used? Who is required? Tx given?
Detain a person who is a voluntary patient in hospital Psych/ non-psych ward (except A&E) Up to 72 hours Renewed/ extended Section 2 or section 3 Doctors in the team on on-call doctors nominated deputy- nominated by one in charged of tx No- except in emergency under common law
37
A person is regarded as being unable to make a decision if, at the time the decision needs to be made, he/ she fails:
To understand the information Retain the information Use/ weigh the information Communicate the decision
38
Assessment of capacity is what and what? Section 5(4) who's holding power? Up to how long?
Time and decision specific | Nurses'- 6 hours
39
Starting a psych interview?
Intro, explain purpose, confirm name+ DOB and address, preferred name, mode of referral
40
HPC for psych hx?
Timeline, impairment- domestic/ social/ occupational, risk behaviours, suicide- risk assessment
41
Past psych hx?
When first develop difficulties, come into contact with services, previous Ix, admissions, suicidal thoughts, self-harm, attempts
42
Past medical hx? Medication?
Med/ surgical issues, previous admissions/ operations, head injury, epilepsy etc Current- OTC, herbal preps, date of initiation, compliance, SEs, allergies, adverse effects
43
Substance misuse hx?
Alcohol- CAGE, primacy, tolerance, withdrawal, relief | Drug hx, IV use, complications, previous tx, smoking- pack years
44
Family hx?
Parents- marital status, ages, relationships | Siblings, children, family hx- issues, suicide, drinking/ psych
45
Personal hx?
Gestation+ development, childhood, schooling, higher education, employment, psychosexual hx Premorbid personality
46
Forensic hx? Social hx?
Police issues | Accomodation, employment, finances, other people, social support, past times, ADLs, driving
47
Physical health?
``` Neuro exam Blood tests ECG Urine drug screen Urine dipstick, CXR ```
48
Factors when assessing risk?
``` Previous violence Relationship of violence--> mental state Lack of supportive relationships Poor concordance with tx, discontinuation/ disengagement Impulsivity Alcohol/ substance abuse Early exposure--> violence Triggers/ changes in behaviour/ mental state prior to previous violence Recent stressors, losses/ threat of loss Factors stopping violence Family/ carers at risk, history of domestic violence Lack of empathy Violence--> personality factors ```
49
Order for overdose/ suicidal attempt history?
``` Intro Name DOB What led up to overdose What, how much Belief in lethality→ protective factors Who found them What happened after Taken with anything Happened before Leave note/ message/ letter How do you feel now Factors leading to overdose Other symptoms- seeing/ hearing things, outside/ inside head, who are they, what are they saying, control of thoughts, delusions Presenting complaints- mood, concentration, sleep, appetite Social hx- drugs/ history, who at home, job, family/ friends, social support, ADLs, anyone to speak to Self-harm/ suicidal thoughts Physical health Scale of 1-10- do it again Insight Plans going out of here- who’s at home, safe at home? Future plans ```
50
What is CBT? Doesn't focus much on what? Less concerned with what? Focus on what? Recognition that thoughts can affect what? Encourages what?
``` The past The relationship with the therapist The practical effects of a problem How we feel Looking at different ways of thinking ```
51
Structure of CBT? Outcome of CBT?
Usually on a one-to-one basis Once-a-week for a few months= 8-12 sessions Uses problem-solving Patient will get homework to do For particular aspects of depression Can help to prevent relapse Usual treatment often continues Therapist undergoes supervision; still keeps confidentiality
52
Mechanism of SSRIs? e.g.? Common SE?
Prevents serotonin reuptake Sertraline, fluoxetine, escitalopram GI upset, sexual problems
53
Mechanism of SNRIs? e.g.? Common SE?
Prevents serotonin and NAD reuptake Venlafaxine, duloxetine GI upset
54
Mechanism of NaSSA? e.g.? Common SE?
Blocks alpha receptors to increase monoamines Mirtazapine Drowsiness, weight gain
55
Mechanism of tricyclics? e.g.? Common SE?
???? Amitriptyline Anticholinergic effects
56
What is ECT?
A treatment that involves sending an electric current through your brain, causing a brief surge of electrical activity within your brain
57
When is ECT used?
``` If you have: severe/ life-threatening depression moderate- severe depression- medication and talking therapies haven't helped Catatonia Severe/ long-lasting episode of mania ```