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Neuroscience > Psychopharmacology > Flashcards

Psychopharmacology Flashcards

1
Q

Barbiturates

A

No longer used

Modulate GABAA channel

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2
Q

Benzodiazepines

A

Diazepam, temazepam

Facilitate GABAA

Anxiolytic

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3
Q

Buspirone

A

High affinity for 5-HT1 reduces serotonin release

Anxiolytic

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4
Q

Beta blockers used for

A

Anxiety

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5
Q

Why do SSRIs treat anxiety?

A

Decrease sensitivity of the 5-HT receptors

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6
Q

Pharmacology of mood stabilisers like lithium?

A

Disrupts PI cycle - inhibition of inositol monophosphatase

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7
Q

What drugs make psychosis worse?

A

DA enhancing drugs (eg. amphetamine) exacerbate psychosis

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8
Q

1st gen antipsychotic action

A

Block D2 receptor causing an antipsychotic effect

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9
Q

Antipsychotic 1st gen drugs

A

Haloperidol Chlorpromazine

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10
Q

Adverse effects of Dopamine antipsychotics

A

Adverse effects: Increased prolactin, parkinsonian-like motor deficits, increased weight gain, tardive dyskinesia.

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11
Q

Second gen antipsychotic drugs

A

Clozapine risperidone aripiprazole

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12
Q

Opiate action

A

Inhibits adenylate cyclase and reduces cAMP levels

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13
Q

Amphetamine

A

Norepinephrine-dopamine releasing agent (NDRA)

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14
Q

Cocaine

A

Combined reuptake inhibitor of serotonin, norepinephrine, and dopamine.

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15
Q

Caffeine

A

Antagonist of adenosine A2A receptors

PDE inhibitor

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16
Q

Caffeine wakefulness effect

A

Antagonism of A2A receptors in the ventrolateral preoptic area (VLPO) reduces inhibitory GABA neurotransmission to the tuberomammillary nucleus, a histaminergic projection nucleus that activation-dependently promotes arousal.

17
Q

Psychotomimetics

A

LSD, mescaline, psilocybin (mushrooms)

Serotonin agonists?

18
Q

THC

A

Partial agonist activity at the cannabinoid receptor CB1, located mainly in the central nervous system, and the CB2 receptor, mainly expressed in cells of the immune system.

Activation of cannabinoid receptors - decrease in the concentration of the second messenger molecule cAMP through inhibition of adenylate cyclase.

19
Q

Ketamine

A

Antagonism of the NMDA receptor is responsible for the anesthetic, analgesic, and psychotomimetic effects of ketamine

Neuroscience (19 decks)

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