Psychiatry IV Flashcards
What are intoxication and dependence of drug abuse?
Intoxication—>disturbances in various physiological levels
Dependence (tolerance)—>need to increase dose to achieve the same effect—>lead to withdraw
What are the criteria for substance use disorder?
- continue to use despite negative personal consequence
- can’t carry out normal work and school
- use in physically dangerous situation (like driving)
- continue to use even though experiencing social problems
- stop doing any social/recreational things
- using greater amount or over a longer period of time
- unable to cut down
- spend a lot of time getting the drug
- continue to use even though knowing its bad for him/her
- crave the drug
What are the score range for substance use disorder?
2-3—>mild
4-5—>moderate
6-7—>severe
Alcohol acts on ___ receptor just like Barbs
GABAa
Signs of alcohol withdraw
Agitation/tremor/insomnia/GI/vital signs go up/withdraw seizures
What to give for alcohol withdraw?
Lorazepam
What is the risk of flumazenil?
Seizure
Signs of benzo/barb withdraw
Agitation/tremor/insomnia/seizures
Chronic drug use increase activity in ___ and decrease in ___ part of the brain?
limbic/prefrontal cortex
3 parts of the brain that regulates mesolimbic reward?
VTA—(give DA)—>nucleus accumbens
Amygdala assigns a pleasure/threat to the link between the above 2
___ part of the brain control the reward system and the drug use
Prefrontal cortex
When you see dilated pupils you think what kind of drugs? what about miosis?
Stimulants/herion and opioids
Signs of withdraw from opioid
Restless/watery eyes/yawning/flushing
5HT/DA/NE and their metabolites?
5HT—>5HIAA
DA—>HVA
NE–>MHPG
What causes panic attack?
Sodium lactate