Psychiatry III Flashcards
Diagnostic criteria for obesity?
More than 20% ideal weight/BMI>30
Block which 3 receptors would cause weigh gain?
H1/M receptor/5HT2c/also block D2 increase prolactin cause weight gain in women
What are some drugs for obesity?
Amphetamine/Orlistat (lipase inhibitor)/topiramate and zonisamide (anti-convulsants)
DSM 5 criteria for anorexia?
Refuse to maintain normal weight/don’t eat/fear of gaining/body image dysmorphism (self restricted)/restricting (don’t purge) and binge type
Highest mortality rate of psych disorder?
Anorexia
What characteristics does anorexia pt usually have?
Rigid/type A personality/high endogenous opiate/Lanugo hair
Treatment for anorexia?
If severe enough—>force feeding tube/have to be firm with them
DSM 5 criteria for bulimia
eating an atypically large amount of food (compulsion)—>1 time a week for 3 month/purging (compensatory behavior) and non purging type/no anorexia symptoms/
Which is more prevalent, anorexia or bulimia?
Bulimia
Which has better prognosis, anorexia or bulimia?
Bulimia
What are some medical signs of bulimia?
Poor dentition/low phosphate and magnesium/salivary enlargement/normal to obese weight/Russel’s sign
Treatment for bulimia?
Psychotherapy/SSRI/TCA
What is the mild anorexia disorder called
Avoidant/restrictive food intake disorder
What is the mild bulimia disorder called
Binge eating disorder
Diagnostic criteria for delusional disorder?
Single focused delusion/no hallucination/normal lives
What is Capgras delusion?
Delusion where pt feels someone has been replaced by an imposter
What is Fregoli delusion?
Delusional disorder that the pt thinks different people are actually the same person that change appearance or in disguise/paranoid—>you are following me….
What is vampirism?
Delusion that one is a vampire
What is lycanthropy?
Delusion that one is a werewolf
What other disorder do pyschopathic cannibalism pts have?
Antisocial/psychopathy/and delusion about eating people
What is folie a deux or shared delusion disorder?
Symptoms of a delusional belief are transmitted from one person to another (voodoo zombie)
What is cotard’s delusion?
Delusion that the pt believe that he/she is dead
What is the heroin like drug that rot flesh?
Krokodil
What is Morgellons/delusional parasitosis?
Delusion that you are infested with parasite and they are underneath your skin/might actually find some bacteria or parasite (self induced)
What is erotomanic delusion?
Pt think another person (stranger/famous people) is in love with him/her
What part of the brain is hyperactive in delusional disorder?
Mesolimbic system with high DA like schizo
Treatment for delusional disorders?
Psychotherapy help to cope/antipsychotic doesn’t work that well—>hard to treat
Progression of Alzheimer’s disease?
Normal—>mild cognitive impairment (mild memory lost) —>dementia
DSM 5 criteria for Azheimer’s?
Mild or major (can’t live alone) neurocognitive disorder. Focus on decline of function/cognition/behaviors
What are early and late onset AD?
Early onset—>30-60/rare/single gene mutation (presenilin 1/2)
Late onset—->over 60 but usually around 80
Some risk factors for AD?
Age/female/fewer year of education/psych illness/alcohol abuse
Distinguish depression from dementia?
On test dementia pt would try to impress but depression pt would not want to participate
Is brain imaging helpful for AD pts?
Not really—>nonspecific findings
What would you see on a PET scan for AD pt?
More blue tone/enlarged ventricles—>less blood flow
The most common frontotemporal dementia is?
Pick’s disease—>decline in social interpersonal conduct (behavioral)—>memory problems come later
What to give frontotemporal dementia pt?
Divalproex for behavioral/SSRI for irritability. depression and impulsive behaviors/don’t use SGA
What’s the brain of an AD pt like?
Cerebral atrophy/hippocampus atrophy
What kind of stain do you use to stain neuritic and neurofibrillary tangles?
Silver stain
What stain is used to confirm the presence of amyloid plaques?
Congo red
Familiar onset AD has higher Abeta40 or 42?
Abeta 42
Where are presenilins located?
Gamma-secretase
What caused the earlier onset of AD?
Down syndrome
What are the 2 types of plaques do you see in AD pt?
Diffuse and neuritic plaques (dark center)
What’s in neurofibrillary tangles?
Hyperphosphorylated Tau proteins
What is granulovacuolar degeneration (GVD) and hirano bodies and where do you see them?
GVD—>granulocyte in a vacuole in a neuron/AD pts or old ppl
Two subtypes of frontotemploral degeneration?
FTLD-tau (Pick’s) and FTLD-TDP
Is senile and memory lost as one ages a normal phenomena?
No
What are the 2 kinds of drugs used for AD?
AChE inhibitor and NMDA receptor antagonists
HTN causes ___ infarct of the ____ and causes ____ dementia?
Lacunar infarcts/lenticulostriate/vascular dementia
Clinically, vascular dementia presents as a ___ progression
Step wise—>decline, level off, decline, level off and repeat/emotionally lability
What other risk factors do vascular dementia pt has?
Cardiovascular
Treatment for vascular dementia
Control cardiovascular risk factors/AD drugs
End stage Parkinson’s show ___ loss
severe neuronal loss
What are other symptoms do you see with lewy body dementia that you don’t see with AD?
Vivid hallucination and delusions/memory less affected/nigral pallor/atrophy of the limbic system/REM sleep disorder (act out dreams)/high neuroleptic sensitivity
What is the appearance difference between the lewy body in substantial nigra and cortical?
SN—->round and dark in the middle
Cortical—>acentral nucleus
Treatment for lewy body dementia?
AChE inhibitor/levodopa for movement disorder/NO antipsychotic drugs
What is mini metal status examination (MMSE)?
Screening tool for dementia (non specific for types)—>out of 30 (higher the better)
What are the 5 areas of MMSE?
Orientation/registration/attention and calculation/recall/language
What is montreal cognitive assessment (MoCA)?
Screening tool for dementia (out of 30)—>more comprehensive than MMSE
What is DEATH for ADL and SHAFT for IADL?
DEATH—>dressing/eating/ambulating/toileting/hygiene
SHAFT—>shopping/housekeeping/accounting/food preparation/transportation
What is the difference between adult home/assisted living facilities and nursing facilities?
Adult home—>rent a room/provides meal/not much medical problem/elderly is independent
Assisted living—>assist with IADLs/no medical nor nursing care
Nursing facilities—>pt is dependent of all ADLs (like incontinence)