Psychiatry Drugs Flashcards

0
Q

What is the benzodiazepine used in alcohol withdrawal?

A

Chlordiazepoxide

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1
Q

What is the fastest acting benzodiazepine?

How quick does this act?

A

Lorazepam
Orally 1 hour
IM 30 mins

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2
Q

What is the trade name for diazepam?

A

Valium

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3
Q

What neurotransmitter do benzodiazepines affect?

Do they enhance or inhibit?

A

GABA

Enhance it’s affect?

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4
Q

What are the therapeutic properties of benzodiazepines?

A
Sedative 
Anxiolytic
Hypnotic (sleep inducing)
Muscle relaxant 
Anticonvulsant
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5
Q

In a rapid tranquilization how much lorazepam would you give?

How much haloperidol?

A

1mg lorazepam

5mg haloperidol

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6
Q

What are the risks with taking benzodiazepines?

A

Respiratory depression

Hypotension

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7
Q

What are the general side effects of antipsychotics?

A
EPSE
Weight gain
Hyperprolactinaemia
Anti cholinergics
Postural hypertension 
Diabetes
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8
Q

How do atypical antipsychotics work?

A

Antagonise the dopamine pathways

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9
Q

How doss aripiprazole work?

A

dopamine parties agonist so has a different effect in meso cortical and mesolimbic areas

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10
Q

In schizophrenia what is the general management?

A
Orlanzepine (atypical)
Then 
Zuclopenthioxol
Then
 Clozapine
Then augment clozapine
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11
Q

Max does of Orlanzepine?

And starting dose?

A

20 mg

Start on 5mg

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12
Q

Starting dose of clozapine?

Max dose?

A

12.5mg

Up to 200mg

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13
Q

How long does it take to titration clozapine up to its full dose?

A

2 weeks

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14
Q

If you miss a dose of clozapine what must happen?

A

Restart titration at 12.5mg

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15
Q

Name 3 atypical antipsychotics

A
Orlanzapine 
Quetiapine
Rispiridone
Aripiprazole
Amisulpride
Zotepine
16
Q

Name 3 typical antipsychotics?

A

Haloperidol
Fluphenazine
Chloepromazine
Promazine

17
Q

Worst antipsychotic for increasing prolactin?

A

Rispiridone

18
Q

What are the symptoms of neuroleptic malignant syndrome?

A
Autonomic dysfuction
- temp /HR / BP
Confusion
Ataxic
High CK
19
Q

What drugs give the risk of neuroleptic malignant syndrome?

A

Antipsychotics

20
Q

What drugs cause anti cholinergics side effects?

A

Antipsychotics
Tricyclic
SNRI (venlefaxine, juloxcitine)

21
Q

What is the safest antidepressant after an MI?

A

Sertraline

22
Q

What SSRI is worse for affecting QTc interval?

A

Citalopram

23
Q

What is a normal QTc?

A

Less than 450

24
Q

Which SSRI is best for a non compliment patient?

A

Fluoxetine

25
Q

Tricyclic antidepressants can cases weight gain, what neurotransmitter is thought to cause this?/

A

Histamine

26
Q

What are the side effects of TCA?

A

Anticholinergic
Postural hypotension
Weight gain
Sedation

27
Q

Apart from depression what can fluoxetine be used for?

A

OCD

Bulimia nervosa

28
Q

Max dose of fluoxetine?

A

60mg

29
Q

Which Antidepressant is more associated with hyponatraemia?

A

SSRIs

30
Q

What drug type is imipramine and lofepramine?

A

Tricyclics

31
Q

What drug type is dosuleptin?

A

Tricyclics

32
Q

Anticholinergic drugs inhibit what type of nerve impulses?

A

Parasympathetic

33
Q

What drugs cane be given to manage EPSEs?

A

Anticholinergics

34
Q

What drugs can be given to manage akathesia?

A

Beta blockers

35
Q

What type of EPSE are oculogyric crisis and torticollis?

A

Acute dystonia

36
Q

What is torticollis?

A

Twisted neck