Psychiatry Drugs Flashcards
What is the benzodiazepine used in alcohol withdrawal?
Chlordiazepoxide
What is the fastest acting benzodiazepine?
How quick does this act?
Lorazepam
Orally 1 hour
IM 30 mins
What is the trade name for diazepam?
Valium
What neurotransmitter do benzodiazepines affect?
Do they enhance or inhibit?
GABA
Enhance it’s affect?
What are the therapeutic properties of benzodiazepines?
Sedative Anxiolytic Hypnotic (sleep inducing) Muscle relaxant Anticonvulsant
In a rapid tranquilization how much lorazepam would you give?
How much haloperidol?
1mg lorazepam
5mg haloperidol
What are the risks with taking benzodiazepines?
Respiratory depression
Hypotension
What are the general side effects of antipsychotics?
EPSE Weight gain Hyperprolactinaemia Anti cholinergics Postural hypertension Diabetes
How do atypical antipsychotics work?
Antagonise the dopamine pathways
How doss aripiprazole work?
dopamine parties agonist so has a different effect in meso cortical and mesolimbic areas
In schizophrenia what is the general management?
Orlanzepine (atypical) Then Zuclopenthioxol Then Clozapine Then augment clozapine
Max does of Orlanzepine?
And starting dose?
20 mg
Start on 5mg
Starting dose of clozapine?
Max dose?
12.5mg
Up to 200mg
How long does it take to titration clozapine up to its full dose?
2 weeks
If you miss a dose of clozapine what must happen?
Restart titration at 12.5mg
Name 3 atypical antipsychotics
Orlanzapine Quetiapine Rispiridone Aripiprazole Amisulpride Zotepine
Name 3 typical antipsychotics?
Haloperidol
Fluphenazine
Chloepromazine
Promazine
Worst antipsychotic for increasing prolactin?
Rispiridone
What are the symptoms of neuroleptic malignant syndrome?
Autonomic dysfuction - temp /HR / BP Confusion Ataxic High CK
What drugs give the risk of neuroleptic malignant syndrome?
Antipsychotics
What drugs cause anti cholinergics side effects?
Antipsychotics
Tricyclic
SNRI (venlefaxine, juloxcitine)
What is the safest antidepressant after an MI?
Sertraline
What SSRI is worse for affecting QTc interval?
Citalopram
What is a normal QTc?
Less than 450
Which SSRI is best for a non compliment patient?
Fluoxetine
Tricyclic antidepressants can cases weight gain, what neurotransmitter is thought to cause this?/
Histamine
What are the side effects of TCA?
Anticholinergic
Postural hypotension
Weight gain
Sedation
Apart from depression what can fluoxetine be used for?
OCD
Bulimia nervosa
Max dose of fluoxetine?
60mg
Which Antidepressant is more associated with hyponatraemia?
SSRIs
What drug type is imipramine and lofepramine?
Tricyclics
What drug type is dosuleptin?
Tricyclics
Anticholinergic drugs inhibit what type of nerve impulses?
Parasympathetic
What drugs cane be given to manage EPSEs?
Anticholinergics
What drugs can be given to manage akathesia?
Beta blockers
What type of EPSE are oculogyric crisis and torticollis?
Acute dystonia
What is torticollis?
Twisted neck
