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M2 Pharm > Psychiatry > Flashcards

Psychiatry Flashcards

1
Q

What class of drugs for anxiety

A

Benzodiazepines

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2
Q

Duration of action for BZD

A

Short (midazolam), Intermediate (Alprazolam, lorazepam), Long (Diazepam)

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3
Q

MoA of BZD

A

Binds to BZD sites in CNS –> increase the frequency of Cl channel opening –> potentiate GABA actions

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4
Q

SE of BZD

A

CNS (increased drowsiness, anterograde amnesia), CVS (decreased BP, respiration), neonatal (floppy child syndrome), tolerance/dependence/withdrawal

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5
Q

What class of drugs for insomnia?

A

BZD and non-BZD hypnotics

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6
Q

Non-BZD hypnotics

A

Zolpidem, zopiclone

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7
Q

BZD-induced sleep

A

Reduced REM and deep sleep

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8
Q

Non-BZD side effects

A

Withdrawal anxiety, abuse potential

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9
Q

Classes of antidepressants

A

SSRI (selective serotonin reuptake inhibitor)
TCA (tricyclic antidepressant)
SNRI (serotonin & norepinephrine reuptake inhibitor)
NaSSA (Noradrenergic & Selective Serotonergic Antidepressants)

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10
Q

SSRI

A

Fluoxetine, Escitalopram, Sertraline

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11
Q

MoA of SSRI

A

Block serotonin reuptake –> increase availability at synaptic cleft –> increase post-synaptic reaction –> increase BDNF –> mood elevation

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12
Q

SSRI DDI

A

P450 inhibition

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13
Q

SE of SSRI

A

Anxiety, weight loss, no fatality in overdose***

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14
Q

TCAs

A

Amitriptyline, Imipramine

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15
Q

MoA of TCA

A

Block reuptake of serotonin and noradrenaline and increases availability at synaptic cleft

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16
Q

SE of TCA

A

FATALITY in overdose, sedation & fatigue, tachycardia, anticholinergic effects (dry mouth, BoV, urinary retention)

17
Q

SNRI MoA

A

Inhibit reuptake of serotonin and noradrenaline

18
Q

NaSSA

A

Mirtazapine

19
Q

MoA of NaSSA

A

Blocks presynaptic a2-adrenergic autoreceptors on noradrenergic & serotonergic pre-synaptic terminals –> loss of inhibition –> increase NA release –> improvement of symptoms

20
Q

SE of NaSSA

A

Anticholinergic effects, agranulocytosis, sedation

21
Q

Classes of antipsychotics

A

Typical: chlorpromazine, haloperidol (Ty CHa)
Atypical: quetiapine, olanzapine, risperidone, clozapine, aripipazole (A QuORCA)

22
Q

MoA of antipsychotics

A

Blockade of dopamine receptors –> reduce dopamine transmission (opposite of dopamine hypothesis for Psychosis)

23
Q

Pharmacodynamics of antipsychotics

A

Typical: Blockade of D2 > 5-HT2
Atypical: Blockade of 5-HT2 > D2

24
Q

SE of typical vs atypical

A

Atypicals have less EPSE than typicals but have dose-dependent weight gain

25
Q

SE of atypicals

A

Agranulocytosis (clozapine), sedation (clozapine, olanzapine), weight gain (olanzapine&raquo_space; riseperidone), dose-dependent EPSE (risperidone)

M2 Pharm (13 decks)

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