Psychiatry Flashcards
MSE - A + B + S
- Stand for
- Looking for (A+B)
- S - parts (3)
- Appearance, behaviour, speech
- Age / ethinicity, clothes/accessories, self care/hygiene, evidence of self harm, eye contact, posture, facial expression, rapport or not, psychomotor (retardation, agitation)
- Rate, volume, tone
MSE - Affect + mood
- . Affect (observe) - definition
- Mood (enquire about) - definition
- Mood - types
- Affect - parts (3) + examples
- Immediately expressed and observed emotion (e.g. the patient’s facial expression or overall demeanour)
- Sustained emotion present long-term that can alter an individual’s perception of the world
- Depressed, anxious, angry/irritable, apathetic, elated
- Quality (e.g. sad, hostile, happy), range (restricted, normal, expansive), intensity (normal, blunted, flat), labile
MSE - Thought form
- Parts (2) + examples
- Linear vs incoherent
- Circumstantial
- Tangiental
- Flight of ideas
- Perseveration
- Speed (accelerated/retarded), flow/coherence (linear, incoherent, circumstantial, tangiental, flight of ideas, perseveration)
- In logical order vs makes no sense
- Lots of irrelevant/unnecessary details (not to the point)
- Moves from one thought to other (relate in some way but never get to point)
- Increased number of ideas, produced at a rapid pace
- Repetition of particular response without stimulus
MSE - Thought content + possession
- Content - what to look out for (5)
- Abnormal possession - types (4) + description
1. Delusions (false reasoning) / abnormal beliefs Obsessions Over valued ideas Suicidal thoughts Homicidal / violent thoughts
- Thought insertion – thoughts put into own mind
Thought withdrawal – thoughts removed from own mind
Thought broadcasting – others can hear thoughts
Thought echo
MSE - Perception
- Abnormal perception - types (3) + description
- Hallucinations - types (5)
- Types of auditory + examples (2)
- Hallucinations - false sensory perception without any relevant external stimulation, patient believes IS real (e.g. hears voices but no sound present)
Pseudo-hallucations - patient aware not real
Illusions - misinterpreted perception such as mistaking a shadow for a person - Auditory, visual, tactile, olfactory, gustatory
- Secondary (voices talking at them), tertiary (about them)
MSE - Cognition
- Abnormal cognition - basic testing (4 parts)
- Detailed testing - how to do
- What to test in orientation (3)
- Orientation, attention, concentration, short-term memory
- Mini-mental state exam
- Time, place, person
MSE - Insight + judgement
- Insight - what it is
- Judgement - how to test
- Able to recognise problem / abnormal experience, if not what do they think is the cause, do they want help
- Problem-solving
MSE - assessing risk
- Components (3)
- How to quantify (3)
- Long-term assessment - components to consider
- Harm to self, harm to others, vulnerability
- How imminent, how likely, severity
- Biological (drugs / alcohol / medication), social situation, psychological state (+ how to support)
Psychiatric history
- Screening questions
- Important PMH (3)
- Low mood, elevated mood/increased energy, delusions, hallucinations, anxiety, obsessions/compulsions
- Head injury / surgery, neurological conditions, endocrine abnormalities
Generalised anxiety disorder
- Physical symptoms
- Medical causes to exclude
- Psychiatric symptoms (in last 2 weeks)
- Assessment tool
- Needs to last for how long for diagnosis
- Management - step 1
- Step 2
- Step 3
- 2nd line drug
- Benzodiazepines for how long
- If symptoms happen sometimes but can’t control
- Trembling, sweating,palpitations, SOB, headaches, hot flushes, muscle ache/tension, irritable, fatigue, restless
- HTN, hyperthyroid, angina, asthma, excessive caffeine
- Nervous/anxious, can’t control worrying, worry too much, can’t relax, restless (can’t sit still), irritable, feeling afraid as if something awful might happen
- GAD-7
- 6+ months, around a range of events / activities
- Education, active monitoring
- Low-intensity psychotherapy (self-help)
- SSRI (sertraline), higher intensity psychotherapy (CBT)
- TCA
- 2-4 weeks maximum (short-term management)
- Panic disorder (same management)
Depression
- Core symptoms (3)
- Biological symptoms (5)
- Cognitive symptoms (5)
- If have psychotic symptoms, they are usually
- Minimum duration for diagnosis
- Minimum core symptoms for diagnosis
- Major depressive disorder diagnosis requirements from DSM-5
- ICD-10 scoring - mild/moderate/severe
- Other scoring system to assess severity
- Neurological conditions causing depression (3)
- Endocrine (3)
- Infections (2)
- Other (2)
- Management - mild - 1st line
- Moderate-severe - 1st line
- Switching antidepressants - guidelines
- Low mood, loss of interest / pleasure, fatiguability
- Sleep change (early morning waking), appetite change, psychomotor retardation/agitation
- Reduced concentration / memory, poor self-esteem, suicidal/self-harm thoughts
- Mood congruent
- 2 weeks (‘over last two weeks, how often’)
- 2
- > 5 over 2 weeks with low mood/interest/pleasure
- Mild - 4, moderate - 5-6, severe - 7+
- PHQ-9
- MS, Parkinson’s, dementia
- Hypothyroidism, Cushing’s, Addison’s
- HIV, hepatitis
- Chronic fatigue, malignancy
- CBT, + follow up within 2 weeks to see if worsening
- CBT + SSRIs
- If SSRI-SSRI, stop 1st + start 2nd (4-7 gap if fluoxetine 1st), cross-taper if SSRI-TCA
Schizoaffective disorder
- Definition
- Mood symptoms (depression, mania) + schizophrenic symptoms (delusions, hallucinations) in the same episode
Schizophrenia - general
- Risk factors
- First rank symptoms (4)
- Other features
- Negative symptoms
- Paranoid - features
- Hebephrenic
- Catatonic
- Residual
- Management
- Family history, black, migration, urban, cannabis
- Auditory hallucination, thought disorder, passivity phenomena, delusional perception
- Impaired insight, neologisms, catatonia
- Apathy, absent / blunted / incongruous affect, alogia, social withdrawal, impaired attention, anhedonia, sexual problems, lethargy, avolition
- Delusions of persecution, delusions of grandeur
- Disorganised; confused, purposeless behaviour
- Excitement and stupor phases (unusual movements)
- Feel like completely recovered when correctly treated
- Antipsychotics, CBT, cardiovascular risk modification
Psychosis
- Psychotic psychopathology - aspects (5)
- Key differentials
- Associated medical conditions
- Need to rule out
- Perception, abnormal beliefs, thought disorder, negative symptoms, psychomotor functions
- Schizophrenia/ schizoaffective, secondary to mood disorder / medical condition / psychoactive substance, delirium / dementia, personality disorder, neurodevelopmental
- Cerebral neoplasm, stroke, trauma, encephalitis, SLE, endocrine, hyperthyroidism, high calcium
- Substance abuse
Neuroleptic malignant syndrome
- When does it occur
- Presentation
- Abnormal bloods
- Complications
- Management
- Hours-days after starting new antipsychotic (1st or 2nd generation)
- Pyrexia, increased muscle tone/rigidity, autonomic lability (HTN, high HR/RR), agitated delirium/confusion
- Raised CK, leukocytosis
- AKI from rhabdomyolysis
- Stop antipsychotic, IV fluids, dopamine agonist (bromocriptine), dantrolene, medical ward
Substance dependence
- Alcohol - units calculation
- CAGE questionnaire to test dependence - Qs (4)
- Post-withdrawal - how long before initial symptoms
- Seizures
- Delirium tremens (+ 1st line management)
- Wernicke’s encephalopathy - features (3)
- Management
- ABV x Vol
- Thought about cutting down, annoyed by criticism of drink, any guilt, eye opener
- 6-12 hours
- 36 hours
- 72 hours (chlordiazepoxide)
- Delirium, opthalmopelgia, ataxia
- Parenteral thiamine
Personality disorder
- History - key points (3)
- Management - medical (3 types used)
- Preferred psychological therapy
Cluster A (‘suspicious’)
- Paranoid
- Schizoid
- Schizotypal
- Source of distress, co-morbid mental illness, specific impairment
- SSRIs, mood stabilisers, benzodiazepines
- Direct behavioural therapy
- Sensitive/unforgiving if offended, no trust, conspiracy
- Indifference to praise/criticism, solitary, no interest in sex/relationships, emotionally cold, few interests
- Ideas of reference (differ from delusions in that some insight is retained), odd beliefs, perceptual disturbance, paranoid ideation/suspiciousness, eccentric behaviour, inappropriate affect, odd (but coherent) speech
Dementia - general
- Reversible causes to rule out
- Blood screen to do so
- Suspected dementia - refer where
- Average life expectancy from diagnosis
Management
- Drug to maintain cognitive function (+ 3 examples)
- Use ^ at what MMSE score
- Drug to use in mod-severe/if 1st line not tolerated
- Anxiolytics - which to use, which to avoid
- Deficiency (vit B12/folate), TSH, calcium, Cushing’s, Addison’s
- TFT, B12, folate, BM, U+E, LFT, infection, autoimmune, CT head
- Memory clinic
- 4 years
- Cholinesterase inhibitors (donepezil, rivastigmine, galantamine)
- 10+
- NMDA receptor antagonists (memantine)
- Use trazdone, avoid benzodiazepines
Lewy-Body dementia
- Features
- Classic pathological feature, in which locations (3)
- Imaging if suspected
- Management - medical
- Which drug completely contraindicated
- Why
- Progressive cognitive impairment, parkinsonism, hallucinations (mostly visual), sometimes delusions, marked fluctuations throughout day, sleep disrupted
- Alpha-synuclein cytoplasmic inclusions (LBs) in substantia nigra, paralimbic and neocortical areas
- DaTscan (single photon emission CT)
- AChE inhibitors, memantine
- Antipsychotics (neuroleptics)
- 50% have catastrophic results, potentially irreversible Parkinsonism, impaired consciousness, severe autonomic symptoms, 2-3x increase in mortality
Dementia - general
- Types (3) + examples
- Age to be classified as early onset
- Symptoms suggesting depression over dementia in memory loss
- Cortical (Alzheimer’s, frontotemporal),
subcorticical (Parkinson’s, Lewy-body, Huntington’s, HIV related), mixed (vascular, infection-induced) - <65
- Short history, rapid onset, biological symptoms, worried about memory, reluctant to take test, variable MMSE, global memory loss
Alzheimer’s dementia
- Risk factors (4)
- Autosomal dominant form - protein mutations (3)
- Pathological changes - macroscopic
- Microscopic (+ 2 proteins involved)
- Biochemical - deficiency in what
- Genetic, vascular, head injury, less education
- Amyloid precursor protein (chromosome 21), presenilin 1 (C 14), presenilin 2 (C 1)
- Widespread cerebral atrophy, cortex + hippocampus
- Cortical plaques (type A beta-amyloid protein), intraneuronal neurofibrillary tangles (excessively phosphorylated tau protein)
- Acetylcholine
Vascular dementia
- Pathophysiology
- Risk factors + their secondary prevention
- Type of deterioration
- Features
- Drug management only if
- Neuron death due to blood flow disruption
- Smoking, T2DM, HTN, cholesterol (aspirin/clopidogrel)
- Stepwise
- Confusion, restless, agitation, can’t organise thoughts, speech/language issues, unsteady/falls, incontinence
- Co-existing Alzheimer’s / Lewy Body dementia
Mental Health Act
- Section 2
- Section 3
- To put section 2/3 in place, need 2 doctors, 1 must be
- Section 4
- Section 17
- Which do police use
- Admission for assessment - 28 days
- Admission for treatment - 6 months
- Section 12 approved
- Emergency admission for assessment - 72 hours (if not time to wait for section 2)
- Community treatment order (supervised, must obey conditions or may be recalled as liable to section 3)
- 136
Bipolar disorder
- Types (2)
- Mania - definition
- Hypomania - definition
- Long-term management - 1st line mood stabiliser
- 2nd line
- Long-term - 1st line for depressive symptoms
Acute mania - management
- If already on mood stabiliser + antidepressant
- If not on mood stabiliser/antipsychotic
- If that (or alternative) not tolerated
- Type I (mania + depression); Type II (hypomania + D)
- Severe impaired function / psychotic symptoms for 7+ days
- Decreased or increased function for 4+ days
- Lithium
- Sodium valproate
- Fluoxetine
- Stop AD, increase MS dose, add AP
- Haloperidol, olanzapine, quetiapine or risperidone
- Lithium / valproate
Frontotemporal dementia (Pick’s disease)
- Features
- What remains relatively intact
- Imaging if FTD suspected
- Diagnostic finding
- Microscopic changes (4)
- Management - do not use what
- Semantic dementia - features
- Progressive non fluent (chronic progressive) aphasia
- Insidious onset, <65yo, personality change, hyperorality, disinhibition, increased appetite
- Memory and visuospatial skills
- FDG-PET or perfusion SPECT
- Focal gyral atrophy with knife-blade appearance (frontal + temporal lobes)
- Pick bodies - spherical Tau aggregations (silver-staining), gliosis neurofibrillary tangles, senile plaques
- AChE inhibitors, NMDA antagonists (memantine)
- Fluent progressive aphasia (conveys little meaning), recent memory better than long time ago
- Non fluent speech (agrammatic short uttering), comprehension preserved
Cognitive function - general
- Different tests (3)
- MMSE - parts (6)
- If considering delirium, use what
- MMSE, MoCa, ACE-R
- Orientation, registration, attention, recall, language, copying
- Confusion assessment method (CAM)
SSRIs
- Action
- Timeline
- How to take
- Length of treatment
- Effects - how long before seen
- Tests
- Important side effects
- Cautions / Contraindications
- Supplementary
- Which antidepressant if recently had MI
- Specifically interact with (+ why)
- Normal starting dose
- Acute withdrawal (sudden stop) - symptoms
- Stop neuronal serotonin uptake, altering brain chemical balance, thought to help mood/physical symptoms
- Once a day
- Tablet
- Stop 6 months after symptoms improve (slow taper)
- 4-6 weeks (ideally try for 4+ weeks before changing)
- -
- GI (N+V, loss of appetite, diarrhoea), anxiety (early but wears off), insomnia, sweating, low Na+ (elderly)
- Caution in epilepsy (lower seizure threshold), young, peptic ulcer, hepatic impairment, suicide risk (need to refer)
Contraindication in mania phase of bipolar - Mind
- Sertraline
- MAOIs e.g. selegiline, rasagiline (inhibit serotonin metabolism, higher risk of serotonin syndrome)
- 20mg PO OD
- GI upset, flu like withdrawal symptoms, insomnia
Eating disorders
- Anorexia nervosa - features
- Abnormal bloods (low, high)
- Diagnosis (DSM 5)
- Bulimia nervosa - features
- Abnormal bloods
- Diagnosis
- Management
- Prescribing caution
- Reduced BMI, bradycardia, hypotension, amenorrhoea, ‘lanugo’ hair on body, hypothermia
- Low K+, low LH/ FSH/oestrogen/testosterone, low T3
High cortisol, GH, cholesterol, carotin, impaired GTT - Restriction of intake, fear of gaining weight, body dysmorphia/denial of seriousness
- Binge eating then purging (vomiting, laxatives), swollen salivary glands, ‘Russel’s sign’ (knuckle calluses)
- Alkalosis (vomiting up stomach HCl), low K+
- Recurrent binge, lack of control, abnormal compensatory behaviour, at least 1x a week for 3 months
- Individual eating disorder CBT, family therapy (kids)
- Medications causing long QT + arrhythmias can cause more of a problem due to electrolyte abnormalities
Suicide risk
- Score
- SADPERSONs score
Serotonin syndrome
- Drug causes
- Features
- Management - mild-moderate
- Addition if severe
- SSRIs, MAOIs, ecstasy, amphetamines
- Neuromuscular excitation (hyperreflexia, myoclonus, rigidity), autonomic NS excitation (hyperthermia), altered mental state
- Supportive IV fluids, benzodiazepines
- Serotonin antagonists (cyproheptadine, chlorpromazine)
Antipsychotics - general
- Target which symptoms of psychosis
- Mechanism of action
- 1st generation - examples
- 2nd generation - examples
- Why 2nd generation better
- Caution in what diseases
- Contraindicated if (2)
- Monitoring - at start
- At 3 months
- At six months
- Yearly
- Positive
- Dopamine (D2 receptor) antagonist
- Chlor/levopromazine, haloperidol
- Olanz/Cloz/Quetiapine, risperidone, amisulpiride
- Better at treating treatment-resistant schizophrenia and negative symptoms, and lower risk of extra-pyramidal side effects
- Any CV disease
- Severe IHD, PMH of neutropaenia
- FBC, U+E, LFT, lipids, weight, fasting BM, prolactin, ECG, BP (+ frequently during dose titration)
- Lipids, weight
- Fasting BM, prolactin
- FBC, U+E, LFT, lipids, weight, fasting BM, prolactin, CV risk assessment
Antipsychotics - side effects
- 2nd generation - higher risk of
- Clozapine - serious side effects (3)
- 1st generation - nigrostriatal pathway (EP) side effects
- Management of EPSEs
- Other side effects - antimuscarinic
- High prolactin (as usually inhibited by dopamine)
- Arrhythmia (+ most commonly caused by)
- Alpha adrenergic receptor blockade - effect
- Histamine blockade - effects (2)
- Effect if epileptic
- Metabolic syndrome - weight gain, DM, lipid changes
- Agranulocytosis, myositis, cardiomyopathy
- Parkinsonian symptom, acute dystonia, akathisia, NMS
- Procyclidine
- Dry mouth, constipation, urinary retention, blurred vision
- Galactorrhoea, amenorrhoea, sexual dysfunction
- Prolonged QT (haloperidol)
- Postural hypotension
- Sedation, weight gain
- Lowers seizure threshold
Tricyclic antidepressants
- Action
- Timeline
- How to take
- Length of treatment
- Effects - how long before seen
- Important side effects - receptors blocked (4)
- Complications - cardiovascular (2)
- Neurological
- Sudden withdrawal
- Contraindications - do not prescribe with
- Inhibit serotonin and noradrenaline uptake at synapse
- Daily
- Tablet/oral solution
- Long-term - at least 6 months after symptoms improve
- 2 weeks
- H1 (sedation), muscarinic (dry mouth, blurred vision, urinary retention, constipation), dopamine (sexual dysfunction, breast changes), alpha
- Arrhythmias, other ECG changes
- Convulsions, hallucinations, mania
- GI upset, flu symptoms, neuro symptoms, sleep change
- MAOIs
Atypical antipsychotics - counselling
- Action
- Timeline
- How to take
- Length of treatment
- Effects - how long before seen
- Tests
- Important side effects
- Complications / Contraindications
- Blocks receptors in brain that allow overactive chemical message transmission between nerve cells, causing schizophrenia
- Daily PO (bedtime) / slow IM (depot) every 2-4 weeks
- Start small dose, build up over 1-2 weeks, adjust
- Long term (keeps symptoms at bay)
- Several days / weeks
- Olanzapine (occasional LFTs), clozapine (WCC for neutropaenia weekly for 18 weeks, every 2 weeks from 18-52 weeks, monthly from 1 year), yearly health screen
- Anti dopamine, histamine, cholinergic, adrenergic
- Complication (NMS, agranulocytosis, withdrawal), contraindicated in liver failure, caution if epilepsy, pregnant, DM, CVD
Lithium - counselling
- Action
- Timeline
- How to take
- Length of treatment
- Effects - how long before seen
- Tests - before starting
- Tests - lithium levels
- Tests - every 6 months
- Important side effects
- Side effects - toxicity
- Complications
- Contraindications
- Other advice - lifestyle
- Mood stabiliser
- 1-2 times daily
- Tablet, capsule or syrup
- Lifelong, with regular psychiatric reviews
- 1-2 weeks, 6-12 months for full effects
- FBC, U+E, TFT, bHCG, ECG, weight, BP, pulse
- At 12 hours, 5 days, then weekly until 4 weeks stable, then every 3 months
- TFT, U+E, Ca2+
- GI (abdominal pain, nausea), metallic taste, fine tremor
Water symptoms (thirst, polyuria, impaired urinary concentration, weight gain, oedema) - GI (anorexia, diarrhoea, vomiting)
Neuromuscular (speak, dizzy, ataxia, twitch, big tremor)
Other (drowsy, restless, apathy) - Renal failure, nephrogenic DI, hypothyroid
- 1st trimester pregnancy, breastfeeding, big CV/renal disease, Addison’s, low Na+, untreated hypothyroid
- Alcohol - max 1-2 units/day
Mood stabiliser - general
- Indications (4)
- Check for what in neck before starting
- Drug interactions (4)
- Important point when prescribing
- Prophylaxis for bipolar / schizoaffective disorder, recurrent depression, manic episode management
- Goitre
- ACE-i, diuretics, NSAIDs, SSRIs
- Prescribe by BRAND
Sodium valproate - 2nd line MS
- Pre-questions
- Taken when
- Number of doses per day
- Avoid what (2)
- Length of treatment
- Side effects (8)
- Monitoring
- Pregnant / trying for a baby / breast feeding, liver/kidney problems
- After meals
- 2-3
- Alcohol, aspirin
- Usually lifelong
- Nausea, stomach pain, diarrhoea, headache, increased appetite/weight gain, fatigue, hair thinning
- Regular LFTs
DVLA
- Must not drive, must inform DVLA during
- May be able to drive, must inform DVLA
- Severe anxiety/depression, acute psychosis, acute mania/hypomania, acute schizophrenia
- ADHD, dementia, mild learning disability, personality disorder
Post-traumatic stress disorder (PTSD)
- Symptoms - re-experiencing
- Hyper-arousal
- Emotional
- Other
- Management - therapy
- If medication necessary, use what
- Flashbacks, nightmares, repetitive and distressing intrusive images)
- Hypervigilance for threat, exaggerated startle response, sleep problems, irritability and difficulty concentrating
- Emotional numbing, depression, anger
- Avoidance of things that could remind them, substance misuse, unexplained physical symptoms
- Watchful waiting to see if symptoms resolve within 4 weeks of event, then trauma-focussed CBT, eye movement desensitisation and reprocessing (EMDR) therapy
- Venlafaxine, SSRI (sertraline), risperidone if severe
Attention deficit hyperactivity disorder (ADHD)
- Definition
- Diagnosis - DSM-5
- Following presentation, do what
- Drug therapy - from what age
- 1st line medication (6 week trial in children) + SEs
- Monitoring requirements in children
- 2nd and 3rd line
- Persistent inattentive + hyperactive/impulsive behaviour, with element of developmental delay
- 6 features up to age 16, 5 from 17+ years old
- 10 week ‘watch and wait’, then refer to secondary care if symptoms persist
- Last resort, from 5+ years old
- Methylphenidate (dopamine/norepinephrine reuptake inhibitor); abdominal pain, nausea, dyspepsia
- ECG at start (potentially cardiotoxic), weight and height every 6 months in children
- Lisdexamfetamine; dexamfetamine if L not tolerated
Personality disorder - cluster B ‘(emotional/impulsive’)
- Antisocial - features
- Borderline (EUPD)
- Histrionic
- Narcissistic
- Against law, commoner in men, deception, impulsive, aggressive, irresponsible, lack of remorse
- Unstable relationships/self image, impulsive, suicidal, anger, avoid abandonment
- Inappropriate seductiveness, centre of attention, shifting shallow emotions, attention seeking, dramatic
- Grandiose self-importance, feel entitled, fantasies about success, takes advantage, no empathy, envy
Personality disorder - cluster C (‘anxious’)
- Avoidant
- Dependent
- Obsessive-compulsive
- Fear of criticism/rejection, feels inferior, social isolation
- Can’t make decisions, lack of initiative, always need support, feel can’t care for themselves
- Details/rules/ perfectionist, dedicated, hoarder