Psychiatry Flashcards

1
Q

Define neurology. (3)

Give 3 examples of neurological pathology. (3)

A

Disorders of nervous system with established aetiologies, demonstrable anatomical pathology and physical symptoms.
Stroke, epilepsy, Parkinson’s.

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2
Q

Define psychiatry. (2)

Give an example of a psychiatric illness. (1)

A

Disorders of mood, thought and behaviour with no or only minor physical symptoms with no visible pathology.
Depression.

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3
Q

Describe the two functional types of neurology. (4)

A

Neurotic disorders - falls within normal experience - depression, anxiety.
Psychotic disorders - falls outside of normal experience - schizophrenia.

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4
Q

Describe the organic type of neurology. (2)

A

Underlying physical pathology causing the disease state - dementia, traumatic brain injury, drug induced.

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5
Q

Describe the principles of psychopharmotherapy. Give two disadvantages of this type of therapy. (3)

A

Identifying chemical imbalances and trying to correct this with drugs. Doesn’t work on everyone and has side effects.

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6
Q

Describe the principles of psychosocial therapy. (2)

A

Seek to work through, understand and find resolutions for mental illness resulting from upbringing and environmental factors.

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7
Q

Give four reasons why there is a need to classify mental illnesses. (4)

A

To enable clinician communication.
To allow understanding of the options following diagnosis.
To classify patients for research
To be able to relate research back to every day patients.

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8
Q

Define “disorder” in relation to psychiatry. (3) Give one example of a thing that is not a disorder. (1)

A

A clinically recognisable cluste of symptoms or behaviours associated in most cases with distress and interference with personal function. Social deviance without personal dysfunction does not count.

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9
Q

Describe four criticisms of classifying patients with mental illness. (4)

A

Categorisation denied unique personal difficulties
Could label deviant behaviour as an illness
Not everyone fits neatly.
Stigma of having the names associated.

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10
Q

Describe the links seen in schizophrenia between occurrence and genetics. Explain what the fact it is not 100% in MZ twins means. (4)

A

1% population risk
More relatives = more risk
45% MZ twin risk
The fact it’s not 100% shows there are environmental factors that play a part too.

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11
Q

Define anxiety. (1)

A

A feeling of worry, nervousness or unease with an uncertain outcome.

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12
Q

Describe 8 symptoms of anxiety.

A
Palpitations
Sweating
Trembling or shaking 
Dry mouth
Difficulty breathing
Chest pain or discomfort 
Nausea or abdominal distress (eg butterflies)
Feeling dizzy, unsteady, faint or lightheaded.
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13
Q

Describe the stages in the stress response. (9)

A

Alarm - noradrenaline release from sympathetic nerves, adrenaline release from adrenal medulla, Cortisol release from the adrenal cortex.
Resistance - action of cortisol is longer lasting which allows maintenance of the stress response.
Exhaustion - prolonged stress causes continued cortisol secretion, leading to muscle wastage, hyperglycaemia, and suppression of the immune system.

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14
Q

Describe the aetiology of anxiety disorders. (3)

A

Generally unknown.

GABA (the main inhibitory neurotransmitter) is low, as is seratonin - these might contribute.

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15
Q

Describe four treatments of anxiety disorders. (9)

A

SSRIs - to increase seratonin
Benzodiazepines - increase GABA transmission but not good for more than 2 weeks due to addiction.
Pregabalin - GABA analogue that increases GABA transmission
CBT - analyse thoughts,

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16
Q

Describe OCD.
Symptoms (2)
Cause (1)
Treatments (3)

A

A balance between obsessions (a thought that dominates past the point of usefulness) and compulsions (obsessional motor acts often done to remove the power of the obsessions).
Caused by re-entry loops in the basal ganglia, and reduced serotonin.
Treated with high dose SSRIs, antipsychotics or deep brain stimulation.

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17
Q

Describe PTSD.
Pathophysiology (1)
Cause (1)
Treatment (2)

A

Repetitive, intrusive recollections of an event of exceptional trauma.
Caused by hyperactivity of the amygdala causing an exaggerated response to a perceived threat.
Treated with anxiety medications and CBT.

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18
Q

Describe the diagnostic criteria for depression. (4)

A

Two of low mood, lack of energy and lack of enjoyment consistently for two weeks.

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19
Q
Describe differences between an adjustment reaction and depression in terms of:
Time period 
Onset speed
Interest levels 
Energy levels
Sleep changes 
Appetite changes
Common associated feelings.
A

Time limited (AR) - Over 2 weeks (D)
Suddenly - gradually
Pre-occupation with the event - lack of interest in anything
Energy not low - energy low
No pattern to sleep disturbances - sleep disturbance
Reduced or increased appetite - reduced appetite and weight loss.
Anger or frustration - low self esteem, guilt or blame.

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20
Q

Describe symptoms of mania. (9)

A
Elevated mood
Increased energy
Pressure of speech (fast talking) 
Reduced sleep
Flight of ideas (changing mind fast)
Loss of normal social inhibitions
Inflated self esteem. 
Psychotic symptoms possible 
Lasts over 1 week.
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21
Q

Describe the diagnosis of bipolar disorder and it’s types. (4)

A

Diagnosis is made following two episodes of a mood disorder, at least one of which is mania or hypomania (don’t need a depressive episode to get diagnosis).
Type 1 - episodes of severe mania
Type 2 - episodes of hypomania only.

22
Q

Describe 7 physical disorders that can cause mood disorders.

A
Hormone disturbance eg thyroid dysfunction
Vitamin deficiencies eg B12
Heart and lungs disorders
Blood vess l malfunction
Kidney disease
Liver disease 
Alcohol or stimulant-drug-comedowns
23
Q

Describe the brains tructures involved in mood disorders. (12)

A

Limbic system - emotion, motivation, memory
Frontal lobes - social / moral reasoning lost, motor function, mood, attention, language (Broca’s).
Basal ganglia:
Motor - Parkinson’s, Wilson’s Disease, Huntington’s
Psychological - emotion, cognition, behaviour.

24
Q

Describe the neurotransmitters affected in mood disorders. (6)

A

Mainly noradrenaline and seratonin, but also GABA, glutamate, ACh and dopamine.

25
Q

Describe the functions of seratonin in the brain. Describe its production and what happens in depression. (7)

A

Sleep, impulse control, appetite and mood.
Produced in Raphe’s Nucleus in the brainstem.
In depression, there are reduced blood levels of tryptophan (precursor to seratonin) so there is less serotonin.

26
Q

Describe the antidepressant drugs available to treat depression that relate to noradrenaline, and name an example of each type. (4)

A

All also affect seratonin.
Tricyclic antidepressants - Amitriptyline.
SNRIs - seratonin and noradrenaline reuptake inhibitors - venlafaxine, duloxetine.

27
Q

Describe the antidepressant drugs available to treat depression that relate to seratonin, and name an example of each type. (8)

A

SSRIs - sertraline, fluoxetine
TCA - amitryptyline
SNRIs - venlafaxine, duloxetine
MAOIs - monamine oxidase inhibitors - phenelzine

28
Q

Describe predisposing factors to mood disorders. (4)

A

Genetic, childhood attachments, experiences, female.

29
Q

Describe perpetuating factors for mood disorders. (7)

A

Stressful job, studies, relationship difficulties, substance misuse, financial strain, housing, unemployment.

30
Q

Describe precipitating factors for mood disorders. (4)

A

Life events relating to losses eg relationships ending, deaths, poor health.

31
Q

Describe some social and psychological interventions for mood disorder treatments. (8)

A

CBT, diet, exercise, sunlight, staying at work, socialising, forcing yourself to do things, avoiding alcohol and drugs.

32
Q

Describe the main types of medications for depression and give an example of each. (13)

A
SSRIs - sertraline 
SNRIs - venlafaxine 
TCAs - amitriptyline 
MOAIs - phenelzine
Mood stabilisers - lithium or sodium valproate
Antipsychotics - quetiapine
33
Q

Describe some disadvantages of mood stabilisers. (4)

A

Lithium - hypothyroidism, nephrotoxity, teratogenic.

Sodium valproate - highly teratogenic.

34
Q

Describe why antidepressants are not prescribed in the depressive episodes of bipolar disorder. (2)

A

Can make mood changes worse. This means we have to check for past episodes of mania when describing antidepressants for depressive episodes.

35
Q

Describe medications that can be prescribed for bipolar disorder and give examples of each in this case. (6)

A

Mood stabilisers - lithium, sodium valproate, carbamazepine.
Antipsychotics - olanzapine.

36
Q

Define psychosis (2)

A

The prescience of hallucinations or delusions - a symptom not a diagnosis.

37
Q

Describe hallucinations. (2)

A

A sensory (often visual) disturbance, common when waking up or going to sleep.

38
Q

Describe delusions. (2)

A

An abnormal belief outside of cultural norms which are unshakable.

39
Q

Describe 8 causes of organic psychosis.

A
Delirium chased by infection
Acute alcohol / drug intoxication
Post-seizure psychosis 
Hyperthyroidism 
Encephalitis 
Hypercalcaemia
Cerebral lupus
Iatrogenic - steroids or LDOPA.
40
Q

Describe any investigations you might undertake if you suspected psychosis in a patient. (10)

A

Bloods - thyroid, anaemia, calcium, WCC, CRP, B12, folate, U+E, LFTs
Full physical

41
Q

Describe the five first rank symptoms of schizophrenia. (10)

A

Auditory hallucinations - thought echo, 3rd person commentary.
Passitivity experiences - action / feeling is caused by an external force.
Thought withdrawal, insertion or broadcast.
Delusional perception - associates terrible things with normal stimuli.
Somatic hallucinations - something “feels” wrong.

42
Q

Describe the differences between positive and negative symptoms in schizophrenia. (4)

A

Positive - added on - hallucinations, delusions, thought disorders.
Negative - taken away - underactivity, low motivation, social withdrawal, self neglect.

43
Q

Describe the pathophysiology of schizophrenia. (4)

A

The mesolimbic pathway is involved in motivation, reward, and pleasure - overactive
The mesocortical pathway is involved causing the negative symptoms - underactive.

44
Q

Describe treatments available for schizophrenia. (5)

A

Typical antipsychotics - block D2 receptors in dopaminergic pathways in mesolimbic and mesocortical pathways - haloperidol.
Atypical antipsychotics - low affinity for D2 and dissociates fast (less side effects).

45
Q

Describe the side effects of antipsychotics used for schizophrenia. (4)

A

Parkinsonism - rigidity, tremour, bradykinesia, acture dystonia.

46
Q

Describe 6 features of catatonia, it’s treatment and it’s cause. (12)

A

More than two weeks, one of: stupor, excitement, negativism, posturism, rigidity, waxy flexibility, command automatism.
Caused by less GABA binding, so loss of inhibitory effect.
Treated with lorazepam and ECT.

47
Q

Why do patients with schizophrenia die earlier than the general population? (2)

A

Often smoke because nicotine might be symptom relief - increased CVD risk.

48
Q

Describe drug induced psychosis. (2)

A

Psychosis induced by a psychoactive substance - meth, LSD, ketamine. Onset during or within two weeks of substance use.

49
Q

Describe affective psychosis. (3)

A

Psychotic experiences that are congruent with mood. Manic patients have grandiose delusions (eg hear the voice of god), and depressed patients often have delusions of guilt.

50
Q

Describe the four types of schizophrenia. (4)

A

Paranoid - delusions or hallucinations common.
Simple - loss of drive, malaise, apathy, no delusions / hallucinations.
Hebephrenic - increased levels of things, can be mistaken for mania.
Undifferentiated - doesn’t fit with the others.

51
Q

Describe post partum psychosis. (4)

A

Onset within days to weeks of delivery, and can develop over hours to days. Must be recognised early to prevent harm to mother or baby. Can present in patients with no psychiatric history, but also can have past history.