Psychiatry Flashcards
Give 3 of Schneider’s first rank symptoms of schizophrenia.
Auditory hallucinations: either 3rd person (voices discussing the patient) or 2nd person (voices telling the patient what to do)
Thought insertion or thought withdrawal
Thought broadcasting (the feeling that their thoughts are no longer private to them)
Passivity of affect, impulse or volition (actions are being controlled by someone else)
Somatic passivity
Delusional perception
A patient tells you that they hear voices in their head. The voices are commentating on the patient and her actions, but not addressing her directly. What symptom does she have? A. Thought insertion B. Thought broadcasting C. 2nd person auditory hallucination D. 3rd person auditory hallucination E. Delusional perception
D. 3rd person auditory hallucination
A patient believes that their thoughts are no longer private and that other people around them are able to listen in. What symptom is this? A. Thought insertion B. Thought broadcasting C. 2nd person auditory hallucination D. 3rd person auditory hallucination E. Delusional perception
B. Thought broadcasting
A patient tells you they have a voice in their head which is constantly criticising them and telling them to self-harm. What symptom is this? A. Thought insertion B. Thought broadcasting C. 2nd person auditory hallucination D. 3rd person auditory hallucination E. Delusional perception
C. 2nd person auditory hallucination
A patient believes the government is placing ideas in their head as part of a wider plot to control them and their family. What symptom is this? A. Thought insertion B. Thought broadcasting C. 2nd person auditory hallucination D. 3rd person auditory hallucination E. Delusional perception
A. Thought insertion
A patient believes that a delivery van parked outside his house is actually being used by the Russians to spy on him. What symptom is this? A. Thought insertion B. Thought broadcasting C. 2nd person auditory hallucination D. 3rd person auditory hallucination E. Delusional perception
E. Delusional perception
Which of the following is a first generation neuroleptic? A. Quetiapine B. Risperidone C. Haloperidol D. Olanzapine E. Clozapine
C. Haloperidol
Which of the following is most likely to cause agranulocytosis? A. Quetiapine B. Risperidone C. Haloperidol D. Olanzapine E. Clozapine
E. Clozapine
Which of the following is most likely to cause tardive dyskinesia? A. Quetiapine B. Risperidone C. Haloperidol D. Olanzapine E. Clozapine
C. Haloperidol (more common in 1st gen. anti-psychotics)
Which of the following anti-psychotics is most likely to cause T2DM? A. Quetiapine B. Risperidone C. Haloperidol D. Olanzapine E. Clozapine
D. Olanzapine
While clozapine and risperidone also can cause metabolic side effects, olanzapine is the most widely reported.
Which of the following medications is indicated as the first line treatment for a depressive episode in a patient with bipolar disease? A. Quetiapine B. Fluoxetine C. Citalopram D. Olanzapine E. Sertraline
A. Quetiapine
If you give a patient with bipolar an anti-depressant when they are in a depressive episode they will become manic
Which of the following is a side effect you might be wary of in a patient on haloperidol? A. Tardive Dyskinesia B. Parkinsonism C. Dystonia D. Akathisia E. All of the above
E. All of the above
These are all extra-pyramidal side effects which are more commonly seen with typical (1st gen.) neuroleptics.
Blockade of which neural pathway/tract by first generation anti-psychotics is responsible for their extra-pyramidal side effects? A. The mesolimbic pathway B. The mesocortical pathway C. The nigrostriatal pathway D. The pyramidal tract E. The corticobulbar tract
C. The nigrostriatal pathway
The blockade of A and B is responsible for most of the anti-psychotic effects caused by 1st and 2nd gen. neuroleptics.
Which receptors are targeted by both 1st and 2nd generation anti-psychotics? A. Pre-synaptic D2 receptors B. Post-synaptic D2 receptors C. Pre-synaptic D1 receptors D. Post-synaptic D1 receptors E. Dopamine receptors
B. Post-synaptic D2 receptors (a type of dopamine receptor)
Which of the following anti-psychotics is licensed for treatment resistant schizophrenia? A. Quetiapine B. Risperidone C. Haloperidol D. Olanzapine E. Clozapine
E. Clozapine
Due to it’s side effect profile it is reserved for treatment resistant cases or for when other anti-psychotics are not tolerated/contraindicated.
Which of the following anti-psychotics is NOT available as a depot injection? A. Quetiapine B. Risperidone C. Haloperidol D. Olanzapine E. Flupenthixol
A. Quetiapine
Give 2 short term and 2 long term side effects of lithium use.
Short term: fatigue, dry mouth, metallic taste, polydipsia, weight gain, nausea and vomiting, fine tremor, polyuria, muscle weakness, oedema
Long term: thyroid disturbances, nephrotoxicity, memory disturbance, T wave flattening, arrythmias
Which of the following blood levels is considered the therapeutic range for lithium? A. 0-1.2 mmol/L B. 1-2 mmol/L C. 0.6-1.2mmol/L D. 1.2-2.6mmol/L E. 0.5-1.5mmol/L
C. 0.6-1.2mmol/L
a) Give 3 features of lithium toxicity.
b) in plasma levels >2mmol/L what else might you expect to see?
Drowsiness, ataxia, lack of coordination, blurrend vision, tinnitus, dysarthria, vomiting, diarrhoea, coarse tremor, muscle weakness and twitching
Above 2mmol/L: hyperreflexia and hyperextension of limbs, psychosis, convulsions, syncope, coma and death.
Which of the following medications increase the risk of lithium toxicity if co-prescribed? A. Ibuprofen B. Ramipril C. Fluoxetine D. Amlodipine E. All of the above
E. All of the above.
The following drugs increase the risk of lithium toxicity:
ACE-Is, ARBs, NSAIDs, SSRIs, anti-epileptics, anti-psychotics (esp. haloperidol), CCBs, diuretics, metronidazole.
A patient who is on lithium to treat bipolar disorder presents to A+E with the early signs of lithium toxicity. You find out that their GP recently started them on a medication to try and reduce swelling around their ankles.
a) Which type of medication might this be?
b) Why has it caused them to suffer lithium toxicity?
c) Give 3 symptoms the patient may be suffering from.
a) a thiazide or loop diuretic
b) diuretics reduce the renal excretion of lithium and so cause the plasma levels to rise.
c) 3 from:
Drowsiness, ataxia, lack of coordination, blurrend vision, tinnitus, dysarthria, vomiting, diarrhoea, coarse tremor, muscle weakness and twitching
Which of the following medications may you use as a prophylactic in bipolar disorder when the patient is resistant to or intolerant of lithium? A. Quetiapine B. Sodium Valproate C. Olanzapine D. Carbamazepine E. Fluoxetine
D. Carbamazepine
This is indicated for the prophylaxis of bipolar in this scenario.
Which of the following medications is a tricyclic anti-depressant? A. Amitryptyline B. Fluoxetine C. Mirtazapine D. Duloxetine E. Quetiapine
A. amitryptiline
Which of the following medications is an SSRI? A. Amitryptyline B. Fluoxetine C. Mirtazapine D. Duloxetine E. Quetiapine
B. Fluoxetine
Which of the following medications is an antagonist of inhibitory pre-synaptic a2-adrenoreceptors? A. Amitryptyline B. Fluoxetine C. Mirtazapine D. Duloxetine E. Quetiapine
C. Mirtazapine (it’s a NaSSA)
Which of the following is an SNRI? A. Amitryptyline B. Fluoxetine C. Mirtazapine D. Duloxetine E. Quetiapine
D. Duloxetine
Which of the following is licensed for treating generalized anxiety disorder? A. Amitryptyline B. Fluoxetine C. Mirtazapine D. Duloxetine E. Quetiapine
D. Duloxetine (SNRIs)
Which of the following is licensed for the treatment of OCD? A. Amitryptyline B. Fluoxetine C. Mirtazapine D. Duloxetine E. Quetiapine
B. Fluoxetine (SSRIs)
Which of the following can be used in the treatment of neuropathic pain? A. Amitryptyline B. Fluoxetine C. Mirtazapine D. Duloxetine E. Quetiapine
A. Amitryptiline (not licensed for this)
Which of the following can increase appetite? A. Amitryptyline B. Fluoxetine C. Mirtazapine D. Duloxetine E. Quetiapine
C. Mirtazapine
A patient on amitryptiline complains of developing increasingly blurred vision and a dry mouth.
a) which receptors have been blockaded by his antidepressant?
b) Give 3 other side effects of TCAs
a) muscarinic receptors
b) sedation, hypotension, QT-elongation, breast changes, sexual dysfunction.
There is also a risk of extra-pyramidal symptoms.
A patient with a history of depression presents to A+E complaining of a tremor which has come on over the last 12 hours. On examination they appear sweaty and restless. On examination they are ataxic, have brisk reflexes and slight muscle rigidity.
a) What is the likely diagnosis?
b) Give a medication which might cause this presentation.
c) Give a possible differential in this case and why it is not the example chosen
a) serotonin syndrome
b) MAOIs, Amphetamines, cocaine, MDMA, SSRIs, SNRIs, NaSSAs, LSD, Lithium
c) Neuroleptic malignant syndrome (minimal muscle rigidity and rapid onset) Lithium toxicity (patient is restless not drowsy and has no GI symptoms that you expect to see in acute toxicity).