Psychiatry Flashcards
What condition causes third person auditory hallucinations?
Schizophrenia
What does mesocortical dopamine hypoactivity cause?
Negative and cognitive symptoms in schizophrenia
What does subcortical dopamine hyperactivity cause?
Psychosis
What is the tuberoinfundibulnar dopamine pathway concerned with?
Prolactin release
What is the nigrostriatal dopamine pathway concerned with?
Extrapyramidal motor movements
What is another name for the subcortical and mesocortical dopamine pathways?
Mesolimbic system
What is the mesolimbic system concerned with?
Motivation and reward
Which of the dopamine pathways in the brain is dysregulated in schizophrenia?
Mesolimbic system
What does Da blockade in the mesolimbic system cause?
Depression
What does Da agonism in the mesolimbic system cause?
Pscyhosis
2 side effects of clozapine?
Agranulocytosis
Weight gain
Which atypical anti-depressant causes the most weight gain?
Olanzapine
Under what conditions can clozapine be prescribed?
By a consultant when the patient has tried 2 other anti-psychotics
Monitoring involved when a patient takes clozapine?
Once a week for the first 6/12
Once every 2 weeks for the next 6/12
Then every 4 weeks thereafter
One month after discontinuation
Limbic system functions?
Motivation Memory Olfaction Visceral afferents Emotion M2OVE
Brain changes in schizophrenia?
Reduced frontal lobe volume (and grey matter)
Enlarged lateral ventricles
Reduced grey matter in the temporal cortex
What is pressure of thought?
Varied ideas in abundance