Psychiatry Flashcards
A pt presents with flattened affect social withdrawal, anhedonia (loss of energy), apathy, poverty of thought and delusions/ disorganized speech or behavior/ hallucinations for more than 1 month but less than 6 months most likely suffers from …
Schizophreniform
A pt presents with flattened affect, social withdrawal, anhedonia (loss of interest), apathy, poverty of thought, and delusions/ hallucinations/ disorganized speech or behavior for at least 1 month with significant impact on social/ occupational functioning for 6 months most likely suffers from…
Schizophrenia
A pt presents with flattened affect, social withdrawal, anhedonia (loss of energy), apathy, poverty of thought and delusions/ disorganized speech or behavior/ hallucinations following a stressful life event and symptoms last less than 1 month at which point the pt returns to baseline most likely suffers from…
Brief Psychotic Disorder
A pt presenting with non-bizarre delusions with no impairment of baseline functioning most likely suffers from …
Delusional Disorder
tx: psychotherapy
What are the two indications to hospitalize a pt presenting with an acute psychiatric condition?
- suicidal (risk to harm self)
2. homicidal (risk to harm others)
What is the best initial test for a patient presenting to the ER with psychosis?
drug screen
What medical conditions and associated testing should be performed in pt presenting with psychosis? (6)
- thyroid disorder (TSH)
- metabolic disorder (basic electrolytes and calcium
- HIV (HIV serology)
- syphilis (VDRL)
- drug intoxication (drug screen)
- temporal lobe epilepsy (auditory & olfactory hallucinations, feeling of deja vu, dissociation)
What is the greatest risk factor for progression to schizophrenia?
schizophreniform disorder (2/3 progress)
What are five indicators of poor prognosis in a schizophrenic?
- early age of onset
- negative symptoms
- poor premorbid functioning
- family history of schizophrenia
- disorganized/ deficit subtype
What is the next best step in management for schizophrenia with bizarre or paranoid symptoms?
hospitalize
What is the best treatment for schizophrenia?
antipsychotics (for 6 months to prevent further episodes)
long term treatment if have history of repeated episodes
What is the best treatment for agitation in a schizophrenic?
benzodiazepines
Other than being used for psychotic disorders (schizophrenia, mania in bipolar, depression with psychotic features), what are two other indications for the use of antipsychotics?
- sedation (if benzos contraindicated or as adjunct during anesthesia)
- movement disorders (huntington’s disease and tourette syndrome)
What are common side effects of low-potency antipsychotics (thioridazine, chlorpromazine)?
- orthostatic hypotension (alpha blockade)
- acute urinary retention
- dry mouth
- blurry vision
- delirium
(swtich to atypical antipsychotic)
What is the common side effects of thioridazine?
- prolonged QT and arrhythmia (obtain EKG)
2. abnormal retinal pigmentation (routine eye exams for chronic use)
What is the next best step in management of a pt presenting with chest pain, shortness of breath, and palpitations with a history of thioridazine use?
obtain EKG (likely prolonged QT or arrhythmia)
What is the most common reason for non-compliance with antipsychotic medication in males?
impotence and inhibition of ejaculation (due to alpha blockade)
What is the most common reason for non-compliance with antipsychotic medication in females?
weight gain (due to hyperprolactinemia along with galactorrhea and amenorrhea)
What is the most problematic complication associated with clonazpine use and what diagnostic test is used to detect this problem?
agranulocytosis; obtain CBC with diff (before initiating and weekly during therapy)
(also causes seizures)
(only used for treatment resistant patients)
What antipsychotic has the greatest weight gain?
olanzapine
What is the common side effect associated with high potency antipsychotics (fluphenazine, haloperidol)?
extrapyramidal symptoms (acute dystonia, bradykinesia, akathasia, tardive dyskinesia, neuroleptic malignant syndrome)
What is the best antipsychotic medication class to give intramuscularly in a pt who is unable or unwilling to take medication PO?
high potency antipsychotics (fluphenazine, haloperidol)
What is the best antipsychotic medication class to give as depot injections for noncompliant patients?
high potency antipsychotics (fluphenazine, haloperidol)
What is the best initial medication for psychosis?
atypical antipsychotics (risperidone, olanzapine, quetiapine, clozapine)
(greater effect on negative symptoms)
What is the antipsychotic medication of choice for treatment of schizophrenia when sedation is a problem (impacting social/ occupational functioning)?
risperidone
What is the antipsychotic medication of choice for treatment of schizophrenia when insomnia is a problem? (4)
- olanzapine
- quetiapine
- ziprasidone
- aripiprazole
A pt (likely young man) develops muscle spasms specifically in the neck resulting in difficulty swallowing about 1 week after starting an antipsychotic most likely suffers from …
Acute Dystonia (torticollis)
What is the best management for a pt who develops acute dystonia while on an antipsychotic?
- reduce dose of antipsychotic
2. give anticholinergic (benztropine, diphenhydramine, trihexyphenidyl)
A pt (likely elderly) develops bradykinesia, tremors, and rigidity weeks after starting an antipsychotic most likely suffers from..
medication induced parkinsonism
What is the best management for a pt who develops medication induced parkinsonism while on an antipsychotic?
- reduce dose of antipsychotic
2. give anticholinergic (benztropine, diphenhydramine, trihexyphenidyl)
A pt develops motor restlessness after being on a antipsychotics for weeks/ chronically most likely suffers from …
Akathisia
What is the best management for a pt who develops akathisia while on an antipsychotic?
- reduce dose of antipsychotic
- add benzo or beta-blocker
- switch to newer antipsychotics
A pt develops choreoathetosis (dance-like movements) and other involuntary movements after chronic use (months to years) with an antipsychotic most likely suffers from …
Tardive Dyskinesia
usually irreversible; symptoms worsen after med discontinuation
What is the best management for a pt who develops tardive dyskinesia while on an antipsychotic?
- stop older antipsychotic
- switch to newer antipsychotic (clozapine)
- can use benztropine
A pt develops muscle rigidity, hyperthermia, volatile vital signs (autonomic instability), altered level of consciousness, leukocytosis, and elevated creatine kinase while on an antipsychotic most likely suffers from…
Neuroleptic Malignant Syndrome
What is the best management for a pt who develops neuroleptic malignant syndrome while on an antipsychotic?
- stop antipsychotic
2. transfer to ICU for monitoring
What is the pathophysiology responsible for dystonic reactions while using antipsychotic medications?
nigrostriatal dopamine D2 receptor blockade leading to striatal cholinergic output
(use anticholinergics to treat)
What medications can result in tardive dyskinesia other than antipsychotics?
dopamine antagonist like antiemetics (metoclopramide, prochlorperazine)
(stop offending agent)
What medical conditions can result in anxiety that interferes with daytime functioning?
- hyperthyroidism
- pheochromocytoma
- excess cortisol
- heart failure
- arrhythmia
- asthma
- COPD
What drugs can result in anxiety that interferes with daytime functioning?
- corticosteroids
- cocaine
- amphetamines
- caffeine
- alcohol/ sedatives withdrawal
A pt develops anxiety, depression and/or irritability shortly after a profound change in their life (divorce, migration, birth of handicapped child) most likely suffers from…
Adjustment Disorder
tx: counseling/ brief psychotherapy with benzos
A pt presents with history of brief attacks of intense anxiety with associated tachycardia, hyperventilation, dizziness, and/or sweating that occur regularly and are associated with a precipitant most likely suffers from …
Panic Disorder
meds used are SSRIs, benzos, imipramine, MAOIs
What is the best initial therapy for Panic Disorder?
Cognitive behavioral therapy (CBT) and/or relaxation training and desensitization (especially if agoraphobic)
A pt presenting with a persistent, unreasonable, intense fear and avoidance of situations/ circumstances/ objects without a known eliciting event most likely suffers from …
Social Anxiety Disorder
A pt who fears and avoids public places due to the anxiety about not being able to escape most likely suffers from …
Agoraphobia
public places, being outside, public transportation, crowds
What is the best treatment for social anxiety disorder?
exposure therapy (increasing exposure to stimulus) using benzos and beta-blockers prior to exposure
A pt presents with excessive, poorly controlled anxiety occurring for more than 6 months in which they worry about multiple circumstances of life and there is no single event/ focus most likely suffers from …
generalized anxiety disorder (GAD)
What is the best treatment for generalized anxiety disorder?
- supportive therapy
2. SSRIs, venlafaxine, buspirone, benzos
What are the three major benzodiazepines in order from shortest to longest half-life?
alprazolam (xanax)
What is the best anxiolytic medication for patients with occupations where driving or using machinery is involved?
buspirone (no sedative effect and no withdrawal syndrome)
5-HT1A receptor partial agonist
A pt presents with recurrent anxiety provoking, intrusive thoughts about contamination/ doubt/ guilt/ agression/ sex, perform peculiar behaviors that reduce this anxiety (such as hand washing, organizing, counting, checking, praying) and recognizes that this behavior is unreasonable and excessive most likely suffers from …
Obsessive-Compulsive Disorder (OCD)
What is the best treatment for obsessive-compulsive disorder?
- behavioral psychotherapy
2. SSRIs or clomipramine
A pt develops intense dreams/ flashbacks/ intrusive recollections of a traumatic event, avoidance of stimuli associated with the trauma or numbing of general responsiveness and hyperarousal (anxiety, sleep disturbance, hypervigilance, emotional lability, impulsiveness) within 1 month of a near-death traumatic experience and symptoms resolve within 1 month most likely suffers from …
Acute Stress Disorder
benzos for acute anxiety; SSRIs for long term therapy
A pt develops intense dreams/ flashbacks/ intrusive recollections of a traumatic event, avoidance of stimuli associated with the trauma or numbing of general responsiveness and hyperarousal (anxiety, sleep disturbance, hypervigilance, emotional lability, impulsiveness) after a near-death traumatic experience and symptoms last longer than 1 month most likely suffers from …
Post-traumatic stress disorder (PTSD)
benzos for acute anxiety; SSRIs for long term therapy
What is the most effective therapy to prevent post-traumatic stress disorder after a life-threatening traumatic event occurs?
group therapy
A pt presents with depressed mood and at least five of the following (changes in sleep, loss of interest/pleasure, guilt or feelings of worthlessness, loss of energy, trouble concentrating, changes in appetite or weight, psychomotor changes, and suicidal ideation) lasting more than 2 weeks most likely suffers from…
Major Depressive Disorder
SMIGECAPS
What are medical causes that can result in depression? (4)
- hypothryoidism (check TSH and give levothyroxine)
- Parkinson’s disease (anti-parkinsons meds)
- medications (steroids, beta blockers, antipsychotics, resperine)
- substance use (alcohol, amphetamines)
What is the best initial therapy for major depressive disorder?
SSRIs (admit if suicidal or homicidal)
use benzos for agitation
What is the best therapy for a major depressive disorder pt who is acutely suicidal or for pts worried about side effects from medication?
electroconvulsive therapy (ECT)
A pt who has depressive symptoms (however less than 5 of SIGECAPS) that are present on most days for at least 2 years most likely suffers from…
Dysthymic Disorder
What is the best treatment for dysthymic disorder?
Long-term individual, insight oriented psychotherapy
A pt who has depressive symptoms (SMIGECAPS) in the winter but no symptoms in the summer most likely suffers from …
Seasonal Affective Disorder
What is the best treatment for seasonal affective disorder?
phototherapy or sleep deprivation
A pt presents with at least 4 of the following (grandiosity, less need for sleep, excessive talking/ pressured speech, racing thoughts/ flight of ideas, distractibility, goal- focused activity at home/ work, sexual promiscuity) for at least 1 week as well as a time period of depression with periods of normalcy in between most likely suffers from ….
bipolar disorder
DIGFAST
A pt that has more than 4 episodes of mania in a year most likely suffers from …
Rapid cycling bipolar disorder