Cardiology Flashcards
What are the risk factors for Coronary artery disease? (8)
- diabetes mellitus
- hypertension
- tobacco use
- hyperlipidemia
- peripheral arterial disease (PAD)
- obesity
- inactivity
- family history (female relative
A pt presenting with chest pain that does not change with body position or respiration and does not have associated chest wall tenderness, it is dull exertional pain lasting 15-30 minutes located over the substernal area radiating to jaw/ left arm, most likely suffers from …
Coronary artery disease (Ischemic heart disease)
A pt presenting with chest pain with associated chest wall tenderness most likely suffers from …
Costochondritis
A pt presenting with chest pain that changes with bodily position most likely suffers from…
Pericarditis
What is the single worst/ most dangerous risk factor for Coronary artery disease?
Diabetes Mellitus
What is the next best step in management of a pt presenting with chest pain associated with epigastric pain, sore throat, bad metallic taste in mouth, and cough?
Start proton pump inhibitor (likely GERD)
What is the next best step in management of an alcoholic pt presenting with chest pain associated with nausea, vomiting and epigastric tenderness?
Check amylase and lipase (likely pancreatitis)
What is the next best step in management of a pt with chest pain, right upper quadrant tenderness and mild fever?
Abdominal Ultrasound (likely gallstones)
What are the four physical exam findings in the cardiovascular exam that could be abnormal in a pt presenting with coronary artery disease?
- S3 gallop (dilated left ventricle)
- S4 gallop (left ventricular hypertrophy)
- Jugulovenous distension
- Holosystolic murmur (mitral regurgitation)
…. is the sound of rapid ventricular filling during diastole when the left ventricle is dilated
S3 gallop
….is the sound of atrial systole into a stiff or non-compliant left ventricle heard just before S1
S4 gallop
What is the best initial step in management of a pt presenting with ischemic type chest pain?
treat with aspirin, nitrates, oxygen and morphine
What is the best initial diagnostic test for ischemic type chest pain?
EKG
What is the most accurate diagnostic test for ischemic type chest pain?
CK-MB or troponin
What is the best diagnostic test to detect reinfarction a few days after the initial coronary infarction?
CK-MB (because only stays elevated for 1-2 days unlike troponin which is elevated for 1-2 weeks)
What cardiac enzyme rises first after an coronary infarction?
myoglobin
What is the next best step in management/ most appropriate further management for a pt presenting with an episode of chest pain that occur a few days ago and has a normal EKG and cardiac enzymes?
Stress test (assess for ST segment depression)
What is the next best step in management of a pt with an abnormal stress test showing an area of reversible ischemia after an episode of chest pain?
Angiography
What is the best initial test to evaluate valve function or ventricular wall motion?
ECHO (echocardiography)
What is the most accurate diagnostic test to evaluate ejection fraction?
Nuclear ventriculogram
What is the next best step in management/ most appropriate further management step for a pt presenting with an episode of chest pain that occurred a few days ago and has a normal EKG and cardiac enzymes and cannot exercise to a target heart rate of >85% of maximum?
dipyridamole or adenosine thallium stress test or dobutamine ECHO
(sestamibi nuclear stress test used in obese or pts with large breast)
What is the next best step in management/ most appropriate further management step for a pt presenting with an episode of chest pain that occured a few days ago and has normal cardiac enzymes and EKG unreadable for ischemia (LBBB, digoxin use, paccemaker, left ventricular hypertrophy, baseline ST segment abnormalities)?
exercise thallium testing or stress ECHO
What is the mechanism of action of P2Y-12 antagonists (clopidogrel, prasugrel, ticagrelor)?
blocks aggregation of platelets to each other by inhibiting ADP-induced activation of P2Y-12 receptor
What has the single greatest efficacy in lowering mortality in ST segment elevation myocardial infarction (STEMI)?
Urgent/ Primary Angioplasty (add prasugrel)
What is are the indications for thrombolytic therapy for a pt founf to have a ST-segment elevation myocardial infarction (STEMI)?
- PCI can not be performed within 90 minutes
2. chest pain for
What six treatments are associated with lowering mortality in pts with acute coronary syndrome (acute chest pain)?
- aspirin
- thrombolytics
- primary angioplasty
- beta blockers (metoprolol)
- statins
- clopidogrel, prasugrel, ticagrelor
What are the indications for using clopidogrel, prasugrel and ticagrelor in an acute coronoary syndrome pt?
- aspirin allergy
- pt receiving angioplasty and stenting
- acute MI (add to aspirin)
What are the indications for using calcium channel blockers in an acute coronary syndrome pt?
- intolerance to beta blockers (such as has asthma)
- cocaine induced chest pain
- coronary vasospasm (Prinzmetal’s angina)
What are the indications for lidocaine or amiodarone in an acute coronary sydrome pt?
ventricular tachycardia or ventricular fibrillation
What is the diagnostic test and treatment for a pt with cardiogenic shock secondary to myocardial infarction?
ECHO or Swan-Ganz catheter; ACE inhibitor and urgent revascularization
What is the diagnostic test and treatment for a pt with valve rupture secondary to myocardial infarction?
ECHO; ACE inhibitor, nitroprusside, or intra-aortic balloon pump to bridge to surgery
What is the diagnostic test and treatment for a pt with septal rupture secondary to myocardial infarction?
ECHO or right heart catheter (showing step up in saturations from right atrium to right ventricle); ACE inhibitor, nitroprusside or urgent surgery
What is the diagnostic test and treatment for a pt with myocardial wall rupture secondary to myocardial infarction?
ECHO; pericardiocentesis or urgent cardiac repair
What is the diagnostic test and treatment for a pt with sinus bradycardia secondary to myocardial infarction?
EKG; atropine followed by pacemaker if symptoms continue
What is the diagnostic test and treatment for a pt with third degree heart block secondary to myocardial infarction?
EKG or canon “a” waves; atropine and pacemaker is symptoms continue
What is the diagnostic test and treatment for a pt with right ventricular infarction secondary to myocardial infarction?
EKG showing right ventricular leads; fluid loading
How long should a pt wait to have sex after a myocardial infarction?
2-6 weeks
What medications should all pts with myocardial infarction be discharged home on?
aspirin, clopidogrel, beta blocker, statin, ACE inhibitor
What are the three differences in the management of non-ST segment elevation myocardial infarction (NSTEMI) when compared to management of ST-segment elevation myocardial infarction (STEMI)?
- no thrombolytic use
- use Low Molecular Weight Heparin
- Glycoprotein IIb/ IIIa inhibitors (eptifibatide, tirofiban, abciximab) to lower mortality
What is the best further office-based management for a patient with chronic angina (chest pain)?
aspirin and metoprolol both reduce mortality
add nitrates to relieve pain then add ranolazine
When are ACE inhibitors/ ARBs indicated for further office based management for a pt with chronic angina (chest pain)?
- congestive heart failure
- systolic dysfunction
- low ejection fraction
What is the main difference between using saphenous vein grafts and internal mammary artery grafts?
venous grafts start to become occluded after 5 years; whereas arterial grafts are often patent at 10 years
What are the indications for treatment of chronic angina with CABG? (4)
- three coronary vessels with >70 % stenosis
- left main coronary artery stenosis > 50-70%
- two vessel in a diabetic
- two or three vessels with low ejection fraction
What is the next best step in management for a pt with coronary artery disease who is found to have an LDL > 100?
start statin
What is the LDL goal for a pt with diabetes?
LDL
What are the four coronary artery disease equivalents?
- diabetes mellitus
- peripheral artery disease
- aortic disease
- carotid disease
What are the side effects of statin therapy?
- liver toxicity (routinely monitor LFTs)
2. rhabdomyolysis (check CPK levels if symptoms)
What medication used in pts with coronary artery disease must be stopped prior to starting sildenafil for erectile dysfunction?
nitrates (can result in dangerous hypotension)
A pt presenting with shortness of breath on exertion, edema, rales, ascites, S3 gallop, orthopnea, paroxysmal noctural dyspnea and fatigue most likely suffers from ….
congestive heart failure (CHF)
What is the mainstay therapy for acute pulmonary edema (worst manifestation of CHF)?
oxygen, nitrates, furosemide, morphine
What diagnostic tests should be performed simultaneously with the initial treatment of acute pulmonary edema?
- Chest X-ray (pulmonary vascular congestion, cephalization of flow, effusion, cardiomegaly)
- EKG (sinus tachycardia, atrial and ventricular arrhythmia)
- oximeter or arterial blood gases (hypoxia, respiratory alkalosis)
- ECHO (distinguish btw systolic and diastolic dysfunction)
What is the next best step in management of a pt with acute pulmonary edema who is not responding to preload reduction (oxygen, nitrates, furosemide, and morphine)?
positive inotropic agents (dobutamine, inamrinone, milrinone)
What is the best therapy for a pt with ventricular tachycardia associated with acute pulmonary edema?
synchronized cardioversion
When is unsynchronized cardioversion indicated?
- ventricular fibrillation without a pulse
2. ventricular tachycardia without a pulse
What are the results on right heart catheter in a pt with pulmonary edema?
decreased cardiac output, increased systemic vascular resistance, increased wedge pressure, increased right atrial pressure
What are the results on right heart catheter in a pt with hypovolemic shock (dehydration)?
decreased cardiac output, increased systemic vascular resistance, decreased wedge pressure, decreased right atrial pressure
What are the results on right heart catheter in a pt with septic shock (massive cytokine release resulting in vasodilation)?
increased cardiac output, decreased systemic vascular resistance, decreased wedge pressure, decreased right atrial pressure
What are the results on right heart catheter in a pt with pulmonary hypertension?
decreased cardiac output, increased systemic vascular resistance, decreased wedge pressure, increased right atrial pressure
What are the major side effects of spironolactone? (2)
- gynecomastia
2. erectile dysfunction
What is the alternative treatment for spironolactone in CHF treatment if side effects occur?
eplerenone
What is the further management for a pt with systolic dysfunction with low ejection fraction CHF after acute pulmonary edema has been stabilized?
ACE inhibitors/ ARBs, metoprolol/ carvedilol, spironolactone/ eplerenone, diuretics, digoxin
What is the further management for a pt with diastolic dysfunction with normal ejection fraction CHF after acute pulmonary edema has been stabilized?
metoprolol/ carvedilol and diuretics
What treatments in the further management of CHF lower mortality? (3)
- ACE inhibitors/ ARBs
- beta blockers (metoprolol, carvedilol)
- spironolactone
What treatment is the most beneficial for a CHF pt with an ejection fraction less than 35%?
implantable cardioverter/ defibrillator (prevent sudden death from arrhythmia)
What treatment is the most beneficial for a symptomatic CHF pt with an ejection fraction less than 35% and a QRS > 120msec?
biventricular pacemaker
What is the absolute contraindication for the use of beta blockers?
symptomatic bradycardia
A young female pt presents with shortness of breath worse with exertion, rales and a systolic murmur heard at the apex that radiates to the axilla, decreases with increased venous return and increases with decreased venous return most likely suffers from …
mitral valve prolapse
A healthy young athlete presents with shortness of breath worse with exertion, rales, and a systolic murmur that decreases with increased venous return and increases with decreased venous return most likely suffers from …
hypertrophic obstructive cardiomyopathy (HOCM)