Psychiatry Flashcards
Management of moderate depression
1, Prescribe an SSRI
2. If ineffective for at least 2-4 weeks > check adherence 3. Increase the dose
4. Change to a different SSRI
5. Try alternative class of antidepressant (atypical antidepressants > Mirtazapine)
Antidepressants should usually show effect in
1-2 week
With good response to SSRIs >
Continue for at least 6 months after remission as this reduces relapse
Patients who had 2 or more depressive episodes in the recent past and who experienced significant functional impairment during episodes
Continue for 2 years
When stopping SSRIs, the dose should be
reduced overa 4-week period
If the patient stopped medications abruptly and experiencing delusions
Neuropsychiatric analysis
Hospital management for depression
- Admission to the psychiatric ward
- investigations
- Treatment with SSRIs or SNRIs
4, Augmentation with lithium with CBT - If nothing works > ECT
Reasons for hospital admission
Serious risk suicide
© Serious risk of harming others
© Significant self-neglect
* Severe depressive or psychotic symptoms
© Lack or breakdown of social support
© Initiation of Electroconvulsive therapy (ECT)
© Treatment-resistant depression (where inpatient monitoring may be helpful)
High mood alone in the question (no mention of low mode at all)
> Hypomania
Low mode alone in the question (no mention of high mode at all)
Depression
High mode and low mode (depression) (no matter time in between
Bipolar
High mode with hallucinations and delusions >
Mania
Risk factors for suicide
- Previous suicide attempts © Previous self-harm
- Depression and other mental health problems
- Alcohol and drug abuse
- Low socio-economic status
Classically, periods of prolonged and profound depression alternate with periods of excessively elevated and irritable mood, known as mania
Bipolar affective disorder (Manic depression)
Features of Bipolar affective disorder
(Manic depression)
Decreased need for sleep
Pressured speech
Increased libido
Reckless behavior without regard for consequences © Grandiosity
More talkative than usual
Treatment for Bipolar affective disorder (Manic depression)
Mood stabilizers
Antipsychotics
It is a mood stabilizer that despite problems with tolerability, it still remains the gold standard in the treatment for preventing recurrences in bipolar disorder.
Lithium
Primary agents of choice for the acute treatment of bipolar disorder (mania) after taking into account both efficacy and tolerability
Antipsychotics
What are the kinds of Mood stabilizers ?
Lithium,
Valproic acid,
Carbamazepine,
Lamotrigine
Points about lithium
Do NOT offer lithium to women who are planning a pregnancy or are currently pregnant, unless antipsychotic medication has not been effective
+ [fa woman taking lithium becomes pregnant consider stopping the drug gradually over4 weeks
- [fa woman continues taking lithium during pregnancy, check plasma lithium levels everyw4eeks, then weekly from the 36% week and adjust the lithium dose to maintain plasma lithium levels at a therapeutic
dose
Tetralogy of lithium
Ebstein anomaly of the heart
Floppy baby
Thyroid abnormalities
A lesser degree of mania with persistent mild elevation of mood and increased activity and energy
Hypomania
Abnormally elevated mood
Mania
Hallucinations or delusions
Mania
No hallucinations or delusions
Hypomania
No hallucinations or delusions
Significant impairment of the impairment of the patient’s day -to-day functioning
Mania
Significant impairment of the| No significant impairmentof the patient’s day
No significant impairment in the patient’s day
patient’s day-to-day functioning
Hypomania
What are the 4 elements of Schizophrenia?
- Auditory hallucinations
- Thought disorder
- Passivity phenomena
- Delusional perceptions
Third-person auditory hallucinations > voices are heard referring to the patient as ‘he’ or ‘she’, rather than ‘you’
Thought echo > an auditory hallucination in which the content is the individual’s current thoughts
- Hearing thoughts after being produced > Echo de la pensée
- Hearing thoughts at the same time or before so thoughts being produced > Gedankenlautwerden
Voices commenting on the patient’s behavior
Auditory hallucinations
The delusional belief that thoughts are being placed in the patient’s head from outside
Thought insertion
The delusional belief that thoughts have been ‘taken out’ of his/her mind
Thought withdrawal
The delusional belief that one’s thoughts are accessible directly to others
Thought broadcasting
Thought blocking
a sudden break in the chain of thought
Bodily sensations being controlled by external influence
Passivity phenomena
A two-stage process where first a normal object is perceived then secondly there is a sudden intense delusional insight into the object’s meaning for the patient e.g. ‘The traffic light is green therefore | am the King’
Delusional perceptions
1st line of management of antipsychotics
Olanzapine or Risperidone
A type of antipsychotic If rapid tranquillization is needed
Diazepam
- Continuous involuntary movements of the tongue and lower face
- Caused by long-term use of antipsychotic drugs
- Often reported by family members as patients are often unaware of these movements
Tardive dyskinesia
Atypical antipsychotics have lower risk of TD
- Risperidone (tabs, injections)
- Olanzapine (tabs)
> better for incompliant patient (Depot, long-acting injections)
Risperidone
Tardive dyskinesia can be treated by
Tetrabenazine
1 week after starting anti-psychotic
Drug-induced parkinsonism
1 month after starting antipsychotics
Akathisia
months-years after starting antipsychotics
Tardive dyskinesia
© Hypersensitivity and an unforgiving attitude when insulted
© Unwarranted tendency to question the loyalty of friends
@Reluctance to confide in others
© Preoccupation with constitutional beliefs and hidden meaning
© Unwarranted tendency to perceive attacks on their character
Paranoid personality disorder
Onset Starts at two three days after birth and lasts 1-2 days
Postpartum blues
Peaks at 3 to 4 weeks postpartum
Postnatal depression
Peaks at 2 weeks postpartum
Postpartum psychosis
Yes Occasional thoughts of
baby harming baby
Postnatal depression
Thoughts of harming baby
Postpartum psychosis
Mother cares for baby - Yes
Postpartum blues
Mostly crying
Postpartum blues
Symptoms of depression:
Feels that she is not
capable of looking after
her child
Feels as if she will not be
a good mother
Tearful, Anxiety
Worries about baby’s
health
Postnatal depression
Psychotic symptoms
E.g. hears voices saying
baby is evil
Insomnia
Disorientation
Thoughts of suicide
Postpartum Psychosis
Management of Postpartum Blues
Reassurance and explanation
Management of Postnatal depression
Antidepressant or cognitive behavioural therapy (CBT)
Management of Postpartum Psychosis
Admit to specialist mother and baby unit if available
Antidepressant, mood stabilizers (i.e. carbamazepine), and electroconvulsive therapy (ECT)
In postpartum depression, 1° line SSRI
Sertraline
Postpartum psychosis usually starts with
postpartum depression
Postpartum psychosis
= Puerperal psychosis
Excessive worry and feelings of apprehension about everyday events, with symptoms of muscle and psychic tension, causing significant distress and functional impairment
Generalized anxiety disorder (GAD)
Symptoms of GAD
Restlessness
Concentration difficulties or ‘mind going blank
Irritability
Muscle tension
Sleep disturbance
Palpitations/tachycardia
Sweating
Trembling or shaking
Breathing difficulties as choking sensation
Chest pain or discomfort
Fear of losing control,
GAD present most days for at least
6 months + 3 or more somatic symptoms
Management of GAD
CBT or applied relaxation or drug treatment
Sertraline (SSRI)
Alternative SSRIs = escitalopram or paroxetine
1:t line =>Management of GAD
Sertraline (SSRI)
Several sudden onset episodes (>2 panic attacks)
A panic attack peaks around 10 min then gradually resolves over the next 20min
Panic disorders
Features of panic attacks
Palpitations, tremors, sweating, shaking, tachycardia, and shortness of breath that develop rapidly
The patient might feel he’s going to die from cardiac or respiratory problems
Dizziness, circumoral paresthesia, carpopedal spasm
Can occur with no obvious trigger and awaken the patient from sleep (nocturnal panic attacks)
In a panic ATTACK, simple breathing exercises and reassurance is all what’s needed
TRUE
Numbness and circumoral paresthesia occur due to hyperventilation and wash of CO2 = respiratory alkalosis
high pH enhances binding between Ca and protein = decreased ionized Ca
Management of panic disorder
CBT or applied relaxation or drug treatment
SSRIs (do NOT use fluoxetine)
if SSRIs contraindicated or no response after 12 weeks = imipramine or clomipramine
In an acute setting = Beta-blockers and Rebreathing into paper bags
DO NOT use benzodiazepine for panic attacks
1° line Management of panic disorder
SSRIs (do NOT use fluoxetine)
Lasts hours-days
Acute stress disorder
Persistent fear and anxiety around people or in certain situations, sufferers fear being criticized. They tend to worry excessively before, during, and after the encounter
Social anxiety disorder (Social phobia)
Anxiety-provoking situations
Meeting people (especially strangers)
Talking in meetings
Talking to authority figures
Eating or drinking while being observed
Going to school
Going shopping
Being seen in public
There are two forms of the condition:
Social anxiety disorder (Social phobia)
- Generalized social anxiety which affects most, if not all areas of life. this is the more common type (70%)
- Performance social anxiety which can be seen in certain situations such as public speaking
Fear of open places or being in situations escape might be difficult or help wouldn’t be available if things go wrong
Agoraphobia
Examples of
- Public transport
- Shopping centers
- Leaving home
Can be recognized at any age
Autism spectrum disorders
Autism spectrum disorders
- Severe difficulties communicating and forming relationships
- Difficulties in language
- Repetitive and obsessive behavior
Asperger
- Autism spectrum disorder except language is normal + normal or high IQ
Develops following a traumatic event, usually after 6 months since the event
Post-traumatic stress disorder (PTSD)
Features of Post-traumatic stress disorder (PTSD)
- Re-experiencing: Flashbacks, nightmares
- Avoidance: Avoiding people, situations or circumstances resembling or associated with the event
- Hyperarousal: Hypervigilance for threat, exaggerated startle response, sleep problems, irritability and
difficulty concentrating - Emotional numbing: Lack of ability to experience feelings
- Depersonalization can be one of the symptoms
Features
- Re-experiencing: Flashbacks, nightmares
- Avoidance: Avoiding people, situations or circumstances resembling or associated with the event
- Hyperarousal: Hypervigilance for threat, exaggerated startle response, sleep problems, irritability and
difficulty concentrating - Emotional numbing: Lack of ability to experience feelings
- Depersonalization can be one of the symptoms