Psychiatry Flashcards
what does aphonia mean?
inability to speak
Causes of aphonia
Recurrent laryngeal nerve palsy
Psychogenic
What is cotard syndrome?
Patient believes they are dead
May stop eating and drinking
What is De Clerambault’s syndrome?
Patient believes a famous person is in love with them
What is delusional parasitosis?
Patient has a fixed delusion that they are infested by bugs
Features of depression in the elderly
Physical complaints
Agitation
Insomnia
Management of depression in the elderly
SSRIs
ECT - contraindications
Raised intracranial pressure
ECT short term side effects
Headache Nausea Short term memory impairment Memory loss of events prior to ECT Cardiac arrhythmia
ECT long term side effects
impaired memory
Stages of normal grief
Denial - may include hallucinations Anger Bargaining Depression Acceptance
How long does normal grief take?
up to 12 months
What is delayed grief?
Grieving starts >2 weeks after death
What is circumstantiality in a mental state exam?
Inability to answer a question without giving excessive, unncessary detail. Person does return to the original point.
What is tangentiality in a mental state exam?
Wandering from a topic without returning to it
What is neoligisms in a mental state exam?
New word formations which might include the combining of two words
What is clang association in a mental state exam?
When ideas are related to each other only by the fact they sound similar or rhyme
What is a word salad in a mental state exam?
Incoherent speech where real words are strung together in nonsense sentences
What is Knight’s move thinking in a mental state exam?
severe type of loosening of associations, where there are unexpected and illogical leaps from one idea to another. This is a feature of schizophrenia
What is flight of ideas in a mental state exam?
There are leaps from one topic to another but with discernible links between them
A feature of mania
What is perseveration in a mental state exam?
Repetition of ideas or words despite an attempt to change the topic
What is echolalia in a mental state exam?
Repetition of someone else’s speech, including the question that was asked
Mirtazapine side effects
Sedation and increased appetite
What is Othello’s syndrome?
Pathological jealousy that their partner is cheating on them
Socially unacceptable behaviour linked to these claims
Features of post concussion syndrome
Headache
Fatigue
Anxiety/depression
Dizziness
What is somatisation disorder?
Multiple physical symptoms for 2 years
Patient refuses to accept reassurance or negative test results
What is illness anxiety disorder? (hypochondriasis)
Persistent belief in presence of underlying serious disease .e.g cancer
Patient refuses to accept reassurance or negative test results
What is conversion disorder?
Loss of motor or sensory function
Not consciously feigned or seeking material gain
What is dissociative disorder?
Separating off certain memories from normal consciousness
What is factitious disorder?
Munchausen’s syndrome
intentional production of physical or psychological symptoms
What is malingering?
fraudulent symptoms to access financial or other gain
Protective factors for suicide
Family support
Having children at home
Religious belief
SSRIs - discontinuation symptoms
Increased mood change Restlessness Difficulty sleeping Unsteadiness Sweating GI symptoms Paraesthesia
SSRIs - interactions
NSAIDs - if prescribed then give PPI
Warfarin/heparin - consider mirtazapine instead
Aspirin
Triptans
Citalopram - effect on QTc interval
Dose dependent QT interval rpolongation
Avoid if long QT syndrome or on other drugs that prolong QT
SSRIs - side effects
GI side effects
Increased risk of GI bleeds
Hyponatraemia
Increased anxiety and agitation after starting SSRI
Examples of SSRIs
Fluoxetine
Paroxetine
Citalopram
How often to review patient when starting SSRI?
review after 2 weeks
unless <30 years then review every week as higher risk of suicidal thoughts and self harm
Features of sleep paralysis
Paralysis shortly after waking up or shortly before falling asleep
Hallucinations during the paralysis
Management of sleep paralysis
Clonazepam
SSRIs risk during pregnancy
1st trimester small increased risk of congenital heart defect
3rd trimester risk of persistent pulmonary hypertension of the newborn
Mental health act - section 2
Admission for assessment for up to 28 days
Approved mental health professional makes application on recommendation of 2 doctors
1 of the doctors must be ‘approved’ under section 12(2) of mental health act
Mental health act - section 3
Admission for up to 6 months, can be renewed
Approved mental health professional along with 2 doctors
Mental health act - section 4
72 hour assessment order
Used in emergency when section 2 would cause delay
GP, nearest relative or approved mental health professional
Mental health act - section 5(2)
a patient who is voluntarily in hospital can be legally detained by a doctor for 72 hours
Mental health act - section 5(4)
Allows a nurse to detain a patient who is voluntarily in hospital for 6 hours
Mental health act - section 17(a)
Supervised community treatment
Can be used to recall patients to hospital if they do not comply
Mental health act - section 135
Court order allowing police to break into property to remove a person to a place of safety
Mental health act - section 136
Someone found in a public place who appears to have a mental disorder can be taken by police to place of safety
only used for up to 24 hours
Treatment for personality disorders
Dialectical behavioural therapy
Risks of antipsychotics in elderly patients
Increased risk of stroke
Increased risk of venous thromboembolism
Which screening questions to ask for depression?
1) in the last month have you been often bothered by feeling down, depressed or helpless?
2) in the last month have you been bothered by having little interest or pleasure in doing things?
Which tools can be used to assess degree of depression?
HAD scale (hospital anxiety and depression)
PHQ-9 (patient health questionnaire)
In patients with subthreshold depressive symptoms, whom should you consider starting antidepressants?
Previous moderate or severe depression
Subthreshold symptoms for at least 2 years or that continue despite other interventions
Chronic physical health problem where mild depression complicates care of physical health
Low intensity psychosocial interventions for mild depression?
Individual guided self-help based on CBT therapy
Computerised CBT
Structured group physical activity programme
Group based CBT
Group based peer support programme for patients with chronic physical health problems
Principles of individual guided self-help based on CBT therapy
Supported by trained practitioner
6-8 sessions face to face or by telephone
over 9-12 weeks
Principles of group based CBT
given by two trained practitioners
10-12 meetings of up to 10 participants
Switching from one SSRI that is not fluoxetine to another SSRI
First SSRI should be withdrawn before alternative started
Switching from fluoxetine to another SSRI
Withdraw fluoxetine then leave a gap of 4-7 days before starting alternative SSRI
Switching from SSRI to tricyclic antidepressant
Cross taper
EXCEPT fluoxetine which should be withrawn
Switching from SSRI that is not fluoxetine to venlafaxine
Cross taper cautiously
Switching from fluoxetine to venlafaxine
Withdraw fluoxetine then start venlafaxine
Which SSRI has the highest incidence of discontinuation symptoms?
Paroxetine
Which antidepressants to use in patients with alcoholism?
Mirtazapine
SSRI of choice post myocardial infarction?
Sertraline
Annual monitoring for patients on olanzapine
Weight Blood pressure FBC Renal function LFT fasting lipids glucose
Venlafaxine - what should be checked before starting and at each dose titration?
Blood pressure
Likely cause of confusion in a patient on an SSRI?
Hyponatraemia
What type of drug is imipramine?
Tricyclic antidepressant
When checking lithium levels, how long after the dose should bloods be taken?
12 hours
1st line treatment for agoraphobia
Sertraline
What % of people with schizophrenia will complete suicide?
10%
Alternative opioid replacement therapy to methadone which is given subcutaneously?
Buprenorphine
Medication used in alcoholics as an “anti craving” medication
Acamprosate
SSRI choice in children and adolescents
Fluoxetine
When stopping an SSRI over how long should you withdraw it?
4 weeks
Which personality disorder shows inappropriate sexual seductiveness?
Histrionic personality disorder
What is a reflex halluncation?
When a normal stimuli precipitates a hallucination
e.g. voices only heard when lights turned out
What is an autoscopic hallucination?
Visual allucination seeing oneself in external space
What is an elementary halluncation?
Simple unstructured sounds e.g. buzzing or whistling
What is capgras syndrome?
Person believes their friend or relative has been replaced by a double
What is couvade syndrome?
‘sympathetic pregnancy’
Which two tricyclic antidepressants are most dangerous in overdose?
Amitryptilline
Dosulepin
Atypical antipsychotics - side effects
Weight gain
Hyperprolactinaemia
Clozapine causes agranulocytosis
What are the advantages of atypical antipsychotics over typical antipsychotics?
Less extrapyramidal side effects
less hyperprolactinaemia
Examples of atypical antipsychotics (4)
Clozapine
Risperidone
Olanzapine
Quetiapine
Side effects of clozapine
Agranulocytosis, neutropenia Reduced seizure threshold Constipation Myocarditis Hypersalivation
Monitoring of patients on clozapine
FBC monitoring
Dose may need adjusting if starts or stops smoking
Baseline ECG
Extrapyramidal side effects in typical antipsychotics
Parkinsonism
Acute dystonia
Akathisia (severe restlessness)
Tardive dyskinesia
What does akathisia mean?
severe restlessness
What drug can be used to manage acute dystonia?
procyclidine
Side effects to typical antipsychotics
Extrapyramidal side effects Antimuscarinic - dry mouth, blurred vision, urinary retention, constipation Weight gain Raised prolactin and galactorrhea Impaired glucose tolerance Neuroleptic malignant syndrome Reduced seizure threshold QT prolongation
First rank symptoms of schizophrenia (4)
Auditory hallucinations
Thought disorder
Passivity phenomena
Delusional perceptions
Schizophrenia - risk factors
Family history Black caribbean Migration Urban environment Cannabis use
Risk of schizophrenia if your monozygotic twin has it?
50%
Risk of schizophrenia if your parent has it?
10-15%
Risk of schizophrenia if your sibling has it?
10%
Risk of schizophrenia if no relative affected
1%
Schizophrenia - poor prognostic factors
Strong family history Gradual onset Low IQ Prodromal phase of social withdrawal Lack of obvious precipitants
Schizophrenia - management
oral atypical antipsychotics
CBT
cardiovascular risk factors
Examples of tricyclic antidepressants
Amitriptyline
Lofepramine
Trazodone
Tricyclic antidepressants - side effects
Drowsiness Dry mouth Blurred vision Constipation Urinary retention QT prolongation
Psychosis - features
hallucinations
delusions
thought disorganisation
Peak age of first psychotic episode
age 15-30
PTSD features
Re-experiencing (flashbacks, nightmares)
Avoidance
Hyperarousal
Emotional numbing
PTSD management
Trauma focused CBT
Eye movement desensitisation and reprocessing
1st line drugs - venlafaxine, SSRIs
OCD - what are compulsions?
repetitive behaviours or mental acts the person feels driven to perform
OCD - what are obsessions?
unwanted intrusive thoughts, images or urges
OCD - management
CBT
exposure and response prevention
SSRI
Conditions associated with OCD
Depression Schizophrenia Sydenham's chorea Tourette's Anorexia nervosa
Monitoring lithium levels
12 hours post dose
every week after starting and after every dose change
once levels stable then every 3 months
Lithium - what other bloods should be monitored?
thyroid and renal function every 6 months
Lithium - side effects
N+V Diarrhoea fine tremor Nephrotoxicity Thyroid enlargement may cause hypothyroidism Weight gain IIH Hyperparathyroidism causing raised calcium
Physical conditions or medication that may cause anxiety
Hyperthyroidism Cardiac disease Salbutamol Theophylline Corticosteroids Antidepressants Caffeine
Management of anxiety - step 1
education, montoring
Management of anxiety - step 2
low intensity psychological interventions
Management of anxiety - step 3
high intensity psychological interventions (CBT) or drugs
Management of anxiety - step 4
specialist management
1st line drug for anxiety
Sertraline
2nd line drug for anxiety
alternative SSRI or SNRI (duloxetine, venlafaxine)
3rd line drug for anxiety
pregabalin
three leading causes of charles-bonnet syndrome
1) age related macular degeneration
2) glaucoma
3) cataracts
Bipolar - 1st line medication
Lithium
Bipolar - 2nd line medication
valproate
Bipolar - management of mania
Stop antidepressant
Start antipsychotic e.g olanzapine or haloperidol
Bipolar - management of depression
fluoxetine
Type 1 bipolar
Mania and depression
Type 2 bipolar
Hypomania and depression
Features of mania
Severe functional impairment
Psychotic features
Lasts over 7 days
Features of hypomania
Lasts 4 days
Decreased or increased function
Management of anorexia nervosa in adults
Eating disorder focused CBT
Maudsley anorexia treatment for adults
Specialist supportive clinical management
Management of anorexia nervosa in children and teenagers
Anorexia focused family therapy
CBT
Features of anorexia nervosa
Low BMI
Bradycardia
Hypotension
Enlarged salivary glands
Blood test findings in anorexia nervosa
Low potassium Low FSH, low LH, low oestrogen, low testosterone Impaired glucose tolerance Low T3 High cortisol, high growth hormone Hypercholesterolaemia Hypercarotinaemia
Management of alcohol withdrawal
Chlordiazepoxide
Diazepam
Features of alcohol withdrawal
tremor
sweating
tachycardia
anxiety
Time frame for alcohol withdrawal after stopping alcohol
6-12 hours
Time frame for seizures after stopping alcohol
36 hours
Time frame for delirium tremens after stopping alcohol
48-72 hours
Features of delirium tremens
tremor confusion auditory and visual hallucinations fever tachycardia
Management of acute stress disorder
trauma focused CBT
Features of acute stress disorder
<4 weeks since event intrusive thoughts = flashbacks, nightmares dissociation negative mood avoidance hypervigilence, sleep disturbance
DVLA - severe anxiety and depression, when should you tell DVLA and stop driving?
Significant memory problems Significant concentration problems Agitation Behavioural disturbance Suicidal thoughts
DVLA - acute psychotic disorder
Must not drive during acute illness
Must notify DVLA
DVLA - hypomania or mania
Must not drive during acute illness
Must notify DVLA
DVLA - schizophrenia
Must not drive during acute illness
Must notify DVLA
DVLA - ADHD
May be able to drive
Must notify DVLA
DVLA - mild cognitive impairment
May drive
Do not need to tell DVLA
DVLA - dementia
May be able to drive
Must notify DVLA
DVLA - mild learning disability
May be able to drive
Must notify DVLA
DVLA - severe learning disability
Must not drive
Must notify DVLA
DVLA - personality disorders
May be able to drive
Must notify DVLA
DVLA - alcohol misuse
Can’t drive until 6 months controlled drinking or abstinence
DVLA - alcohol dependency
Can’t drive until 12 months controlled drinking or abstinence
DVLA - cannabis, amphetamines, ecstasy, LSD
Can’t drive until 6 months free
May need assessment and urine screen by DVLA
DVLA - heroin, cocaine, methadone
Can’t drive until 6 months free
May need assessment and urine screen by DVLA