Psychiatric drugs 2 Flashcards
Classes of drugs for anxiety
High dose antidepressants
Benzodiazepines
Beta blockers
Pregabalin
MoA of benzodiazepines in anxiety
Positive allosteric modulators of GABA receptors which decreases excitability of neurones
MoA of beta blockers in anxiety
Prevent bio-psycho-feedback
Stop tremors so stop anxiety effect
MoA of pregabalin in anxiety
Binds to voltage gated calcium channels causing increased GABA in brain
This inhibits neuronal activity in brain
Classes of drugs for insomnia
Benzodiazepines
Z drugs - zopiclone
Classes or drugs for bipolar disorders
Lithium
Antiepileptics
Atypical antipsychotics - quetiapine 1st line
Short term side effects of lithium
GI side effects Polyuria Polydipsia Metallic taste in mouth Fine tremor Weight gain
Long term side effects of lithium
Hypothyroidism
Renal impairment
Treatment for lithium toxicity
Fluids
Dialysis
Signs of lithium toxicity
Confusion Course tremor N+V Ataxia Seizures
What can increase potential for lithium toxicity
Dehydration
NSAIDs
Loop diuretics
ACEi
Example of acetylcholine inhibitors for dementia
Donepezil
Rivastigmine
What do acetylcholinesterase inhibitors treat in Alzheimer’s
Cognitive and neuropsychiatric symptoms
Especially apathy
What does memantine treat in Alzheimer’s
Agitation
MoA of memantine
NMDA antagonist
