Psych Random Facts

Question 1

NT in anxiety

Answer 1

Increased norepi, decreased GABA, decreased serotonin

Question 2

NT in depression

Answer 2

Decreased norepi, serotonin, and dopamine

Question 3

NT in Huntington’s

Answer 3

Decreased GABA, decreased ACh, increased dopamine

Question 4

NT in Parkinson’s

Answer 4

Decreased dopamine, increased ACh

Question 5

NT in Scizophrenia

Answer 5

Increased dopamine

Question 6

Sleep changes in depression

Answer 6

Decreased slow wave sleep, Decreased REM latency, increased rem early in sleep cycle, increased total rem, early morning weakening. Repeated nighttime awakenings

Question 7

NT in Alzheimer’s

Answer 7

Decreased Ach, increased glutamate

Question 8

When do sleep terrors occur?

Answer 8

During slow wave sleep (non-REM)

Question 9

Electrolyte abnormality in refreshing syndrome

Answer 9

Hypophosphotemia, hypomagnesemia

Question 10

Cause of narcolepsy

Answer 10

Decreased hypocretin (orexin) production in lateral hypothalamus

Question 11

Treatment for cocaine intoxication

Answer 11

Alpha-blockers, benzodiazepines. Beta-blockers not recommended

Question 12

MOA of varenicline

Answer 12

Partial agonist of nicotinic ACh receptor. Reduces nicotine withdrawal, prevents nicotine from binding and inducing reward response

Question 13

MOA of PCP

Answer 13

NMDA receptor antagonist

Question 14

MOA of naltrexone

Answer 14

Blocks the mu-opioid receptor, blocks the rewarding and reinforcing effects of alcohol-> reduces cravings

Question 15

What can you use venlafaxine for?

Answer 15

PTSD, panic disorder

Question 16

Pharmacology for Tourette syndrome

Answer 16

Antipsychotic (fluphenazine, pimozide), tetrabenazine, clonidine

Question 17

High potency antipsychotics

Answer 17

Haloperidol, trifluoperazine, fluphenazine

Question 18

What effect does blocking D2 receptors have?

Answer 18

Increases cAMP

Question 19

Tx for EPS

Answer 19

Benztropine or diphenhydramine

Question 20

SE of chlorpromazine

Answer 20

Antichiolinergic, antihistamine, and anti-alpha 1 adrenergic PLUS corneal deposits

Question 21

SE of thioridazine

Answer 21

Antichiolinergic, antihistamine, and anti-alpha 1 adrenergic PLUS retinal deposits

Question 22

What cardio effect might typical and atypical antipsychotics have

Answer 22

Prolong the QT interval

Question 23

What medications may cause lithium toxicity?

Answer 23

Thiazides, NSAIDS, and ACE inhibitors

Question 24

MOA of buspirone

Answer 24

Stimulates 5-HT1A receptors

Question 25

Tx of serotonin syndrome

Answer 25

Cyproheptadine (5HT2 receptor antagonist)

Question 26

Most common side effect of SNRIs

Answer 26

Increased blood pressure

Question 27

MOA of mirtazapine

Answer 27

Alpha-2-antagonist (increases release of norepi and serotonin) and potent 5-HT2 and 5-HT3 receptor antagonist