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Step 1 > Psych Random Facts > Flashcards

Psych Random Facts Flashcards

1
Q

NT in anxiety

A

Increased norepi, decreased GABA, decreased serotonin

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2
Q

NT in depression

A

Decreased norepi, serotonin, and dopamine

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3
Q

NT in Huntington’s

A

Decreased GABA, decreased ACh, increased dopamine

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4
Q

NT in Parkinson’s

A

Decreased dopamine, increased ACh

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5
Q

NT in Scizophrenia

A

Increased dopamine

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6
Q

Sleep changes in depression

A

Decreased slow wave sleep, Decreased REM latency, increased rem early in sleep cycle, increased total rem, early morning weakening. Repeated nighttime awakenings

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7
Q

NT in Alzheimer’s

A

Decreased Ach, increased glutamate

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8
Q

When do sleep terrors occur?

A

During slow wave sleep (non-REM)

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9
Q

Electrolyte abnormality in refreshing syndrome

A

Hypophosphotemia, hypomagnesemia

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10
Q

Cause of narcolepsy

A

Decreased hypocretin (orexin) production in lateral hypothalamus

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11
Q

Treatment for cocaine intoxication

A

Alpha-blockers, benzodiazepines. Beta-blockers not recommended

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12
Q

MOA of varenicline

A

Partial agonist of nicotinic ACh receptor. Reduces nicotine withdrawal, prevents nicotine from binding and inducing reward response

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13
Q

MOA of PCP

A

NMDA receptor antagonist

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14
Q

MOA of naltrexone

A

Blocks the mu-opioid receptor, blocks the rewarding and reinforcing effects of alcohol-> reduces cravings

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15
Q

What can you use venlafaxine for?

A

PTSD, panic disorder

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16
Q

Pharmacology for Tourette syndrome

A

Antipsychotic (fluphenazine, pimozide), tetrabenazine, clonidine

17
Q

High potency antipsychotics

A

Haloperidol, trifluoperazine, fluphenazine

18
Q

What effect does blocking D2 receptors have?

A

Increases cAMP

19
Q

Tx for EPS

A

Benztropine or diphenhydramine

20
Q

SE of chlorpromazine

A

Antichiolinergic, antihistamine, and anti-alpha 1 adrenergic PLUS corneal deposits

21
Q

SE of thioridazine

A

Antichiolinergic, antihistamine, and anti-alpha 1 adrenergic PLUS retinal deposits

22
Q

What cardio effect might typical and atypical antipsychotics have

A

Prolong the QT interval

23
Q

What medications may cause lithium toxicity?

A

Thiazides, NSAIDS, and ACE inhibitors

24
Q

MOA of buspirone

A

Stimulates 5-HT1A receptors

25
Q

Tx of serotonin syndrome

A

Cyproheptadine (5HT2 receptor antagonist)

26
Q

Most common side effect of SNRIs

A

Increased blood pressure

27
Q

MOA of mirtazapine

A

Alpha-2-antagonist (increases release of norepi and serotonin) and potent 5-HT2 and 5-HT3 receptor antagonist

Step 1 (18 decks)

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