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COC N126 Psych 🧠 > Psych Pharmacology (PPt + Book) Chapter 4 > Flashcards

Psych Pharmacology (PPt + Book) Chapter 4 Flashcards

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1
Q

Dopamine is balanced by what neurotransmitter?

A

Acetylcholine

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2
Q

Acetylcholine plays a role in…
(4 functions)

A

Arousal
Sleep wake cycle
Memory
Skeletal muscle movement

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3
Q

Deficiency in acetylcholine is linked to what diseases? (3)

A

Mainly: Alzheimer’s
Also: Huntington’s chorea and Parkinson’s

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4
Q

What moods does acetylcholine regulate? (2)

A

Mania and sexual aggression

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5
Q

An excess in Acetylcholine results in what disease?

A

Depression

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6
Q

What type of receptors does acetylcholine act on? (2 types)

A

Nicotinic and muscarinic receptors
M1, M2, M3

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7
Q

Dopamine (DA) is linked to what functions? (4)

A

Fine muscle movement
Integration of emotions and thoughts
Decision making
Stimulates hypothalamus to release hormones

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8
Q

Dopamine acts on what receptors?

A

D1, D2, D3, D4, D5

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9
Q

An excess in Dopamine can result in what diseases? (2)

A

Psychosis
Mania

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10
Q

A deficiency in Dopamine can result in what diseases? (2)

A

Parkinson’s disease
Depression

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11
Q

Dopamine is involved in what centers of the brain?

A

Reward and pleasure centers

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12
Q

Drugs such as __ may interfere with the __ of dopamine thereby allowing more of the neurotransmitter to stay active in the synapse for a longer time.

A

Cocaine; reuptake

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13
Q

Drugs such as amphetamines that stimulate dopamine activity can induce ___symptoms

A

Psychotic

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14
Q

Drugs that block dopamine receptors have ___ activity

A

Antipsychotic

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15
Q

Norepinephrine (NE) affects what functions? (2)
And stimulates what type of response?

A

Attention, arousal
“Fight or Flight”

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16
Q

An excess in Norepinephrine may result in? (3)
“MAP”

A

Mania
Anxiety
Psychosis

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17
Q

A deficiency in norepinephrine will result in?

A

Depression

18
Q

Norepinephrine mainly acts on what type of receptors?

A

Alpha receptors

19
Q

Many FGA (First Generation Antipsychotic) drugs act as ___ at the alpha receptors for norepinephrine.

A

Antagonists

20
Q

Blockage of alpha receptors can cause vasodilation which can lead to… (3)

A

Vasodilation
Drop in blood pressure
Orthostatic hypotension

21
Q

Blockage of alpha 1 receptors on the vas deferents can lead to ___

A

A failure to ejaculate

22
Q

Serotonin affects what body functions? (6)

A

Mood
Sleep regulation
Hunger
Pain perception
Aggression and Libido
Hormonal Activity

23
Q

Excess serotonin can lead to what disease?

A

Anxiety

24
Q

Decreased levels of serotonin may lead to what disease?

A

Depression

25
Q

Serotonin Syndrome

A

Serotonin toxicity usually caused by two serotonergic medications being taken at the same time.

26
Q

What drug interactions may lead to serotonin syndrome? (2)

A

St. John’s wort, and OTC cough/cold medication containing dextromethorphan

27
Q

Signs and symptoms of serotonin syndrome

A

Mild; restlessness, shivering, and diarrhea

Severe; muscle rigidity, fever, and seizures

28
Q

Histamine affect what body functions? (3)

A

Alertness
Inflammatory response
Stimulates gastric secretion

29
Q

Decreased levels of histamine may lead to what diseases? (2)

A

Sedation, Weight gain

30
Q

Many ___ drugs block the H1 receptors for histamine leading to… (2)

A

Sedation and wight gain which may be beneficial depending on the patient’s condition.

31
Q

GABA affects what body functions?(3)

A

Anxiety
Excitation
Aggression

32
Q

GABA may be used to treat what condition?

A

Seizures due to its anticonvulsant and muscle relaxing properties

33
Q

Increased GABA may lead to

A

Reduction of anxiety

34
Q

Decreased GABA may lead to

A

Mania, anxiety, psychosis

35
Q

Excess glutamate can lead to…

A

Cell death

36
Q

What disease could occur as a result of elevated glutamate?

A

Alzheimer’s disease

37
Q

Glutamate is an excitatory neurotransmitter that activates _ receptors

A

N-methyl-D-aspartate
(NMDA)

38
Q

Glutamate plays a role in what body functions? (2)

A

Learning and memory

39
Q

Decreased levels of NMDA can lead to…

A

Psychosis

40
Q

Substance P is…

A

Pain receptor

COC N126 Psych 🧠 (9 decks)

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