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4th Week > psych pharm > Flashcards

psych pharm Flashcards

1
Q

Treatment for:

ADHD

A

methylphenidate

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2
Q

Treatment for:

alcohol withdrawal

A

Benzos

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3
Q

Treatment for:

Anxiety (3)

A

SSRI
SNRI
buspirone

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4
Q

Treatment for:

bipolar

A 
Mood stabilizers (Li, Valproic acid, carbamazepine)
atypical antipsychotics
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5
Q

Treatment for:

Bulimia

A

SSRIs

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6
Q

Treatment for:

Depression (5)

A 
SSRIs
SNRIs
TCAs
Bupropion
mirtazapine (especially with insomnia)
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7
Q

Treatment for:

OCD (2)

A

SSRI

clomipramine

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8
Q 
Treatment for:
Panic disorder (3)
A

SSRI
venlafaxine
benzodiazepines

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9
Q

Treatment for:

PTSD

A

SSRI

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10
Q

Treatment for:

Schizophrenia

A

antipsychotics

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11
Q

Treatment for:

social phobias

A

SSRIs

beta-blockers

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12
Q

Treatment for:

Tourettes

A

antipsychotics (eg haloperidol, rispiridone)

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13
Q

Methylphenidate MoA

A

CNS stimulant

increase catecholamines at synaptic cleft

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14
Q

Dextroamphetamine MoA

A

CNS stimulant

increase catecholamines at synaptic cleft

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15
Q

methamphetamine MoA

A

CNS stimulant

increase catecholamines at synaptic cleft

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16
Q

Phentermine MoA

A

CNS stimulant

increase catecholamines at synaptic cleft

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17
Q

how can you recognize a typical antipsychotic

A

haloperidol + “azine”s

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18
Q

MoA of typical antipsychotics

A

block D2 receptors –> increase cAMP

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19
Q

what are the high potency neuroleptics

A

Trifluoperazine, fluphenazine, haloperidol (try to fly high)

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20
Q

typical AEs of high potency neuroleptics

A

extrapyramidal symptoms

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21
Q

what are the low potency neuroleptics

A

Chlorpromazine, Thioridazine (cheating thieves are low)

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22
Q

what are typical AEs of low potency neuroleptics

A

anticholinergic, antihistamine, and alpha blocker effects

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23
Q

Which antipsych causes corneal deposits

A

Chlorpromazine

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24
Q

Which antipsych causes retinal deposits

A

Thioridazine

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25
Q

Evolution of EPS side effects (4)

A

4 hours - acute dystonia
4 days - akinesia (parkinsonian)
4 weeks - akanthisia (restlessness)
4 months - tardive dyskinesia

26
Q

what is acute dystonia, what is treatment?

A

muscle spasm, stiffness, oculogyric crisis (4 hours after)

- Tx: anti-cholinergic

27
Q

What is Neuroleptic malignant syndrome. what is treatment

A
  • muscle rigidity, myoglobulinuria, autonomic instability, fever
  • Tx: dantrolene, D2 agonists (bromocriptine)
28
Q

What are the atypical antipsychotics (6)

A 
olanzapine
clozapine
quetiapine
risperidone
aripiprazole
ziprasidone
its ATYPICAL for OLd CLOSets to QUIETly RISPER from A to Z
29
Q

which atypical antipsych can be used for OCD, anxiety disorder, depression, mania, tourettes

A

Olanzapine

30
Q

which atypical may prolong QT interval

A

Ziprasidone

31
Q

Which atypical can cause agranulocytosis

A

Clozapine

32
Q

Which atypicals can cause weight gain

A

Olanzapine and Clozapine

-Oh man… shes huge… shes going to need to restock her clozet

33
Q

which atypical can cause lactation and gynecomastia

A

Risperidone (increases prolactin –> dec GnRH, LH, FSH)

RISe in prolactin

34
Q

Lithium AEs

A 
LMNOP
Lithium side effects
Movement (tremor)
Nephrogenic diabetes insipidus
hypOthyroidism
Pregnancy probs (ebsteins)
35
Q

Elimination of lithium

A

exclusively kidneys

most is reabsorbed with Na in proximal tubules

36
Q

Buspirone MoA and use

A

5HT1A receptor agonist

  • treat generalized anxiety disorder
  • “im anxious if the BUS will be ON time”
37
Q

how to recognize a TCA?

A

end in -iptyline or -ipramine

except doxepin and amoxapine

38
Q

MoA of TCAs

A

block reuptake of NE and 5HT

39
Q

TCA toxicity

A
  • sedation
  • alpha 1 blocker (postural hypoTN
  • anticholinergic (atropine-like effects)
  • Tri-C’s
40
Q

What are the Tri-Cs of TCA tox

A

Convulsions
Coma
Cardiotoxicity

41
Q

treatment for TCA cardiotoxicity

A

NaHCO3

42
Q

Which TCA is less sedating?

A

Desipramine

43
Q

what major AE is seen with desipramine

A

higher seizure incidence

44
Q

what are the SSRIs

A

FLuoxetine, PARoxetine, SErtraline, CITalopram

FLashbacks PARalyze SEnior CITizens

45
Q

MoA of SSRI

A

block serotonin reuptake

46
Q

What is serotonin syndrome

A 
hyperthermia
myoclonus
CV collapse
flushing
diarrhea
seizures
47
Q

treatment for serotonin syndrome

A

cyproheptadine (5HT antagonist)

48
Q

SNRIs. name them

A

Venlafaxine
Duloxetine

(I’ve got a VD and I’m SNRI im not snorry)

49
Q

MoA of venlafaxine

A

inhibit 5HT and NE reuptake

50
Q

Venlafaxine used for depression and what else

A

GAD, and panic disorders

51
Q

duloxetine used for depression and what else

A

diabetic peripheral neuropathy

52
Q

Name the MAOIs

A 
MAO Takes Pride In Shanghai
Tranylcypromine
Phenelzine
Isocarboxazid
Selegiline
53
Q

Which MAO-I is selective for MAO-B

what does MAO-B do

A

selegeline

MAOB breaks down dopamine

54
Q

MoA of MAO-Is

A

increases levels of amine neurotransmitters (NE, 5-HT, dopamine)

55
Q

AE of MAOIs

A

Hypertensive crisis with tyramine.

can cause serotonin syndrome

56
Q

Buproprion MoA

A

increases NE and doamine via unknown mechanism

57
Q

Buproprion use

A

atypical antidepressant

smoking cessation

58
Q

Buproprion AE

A

-stimulant effects
SEIZURES in bullemics
NO SEXUAL side effects

59
Q

Mirtazapine MoA

A

alpha2 antagonist

potent 5HT2 and 5HT3 antagonist

60
Q

Mirtazapine AE

A

sedation (useful if depressed person with insomnia)

- weight gain (Mirt makes you want zerts)

61
Q

Trazodone MoA and use

A

primarily blocks 5HT2 and alpha1 receptors

- used for insomnia

62
Q

Trazodone AE

A

sedation
priapism
postural hypoTN

4th Week (7 decks)

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