DNA viruses

Question 1

herpesvirus structure

Answer 1

enveloped linear dsDNA

Question 2

hepadnavirus structure

Answer 2

enveloped partially ds and circular

Question 3

adenovirus structure

Answer 3

nonenveloped ds linear

Question 4

parvovirus structure

Answer 4

nonenveloped ss and linear (-)

Question 5

papillomavirus

Answer 5

nonenveloped ds and circular

Question 6

polyomavirus

Answer 6

nonenveloped ds and circular

Question 7

poxvirus

Answer 7

enveloped ds and linear

Question 8

Hepadnavirus. whats special and what disease

Answer 8

HBV

- has reverse transcriptase

Question 9

What dzs does adenovirus cause

Answer 9

• febrile pharyngitis
• acute hemorrhagic cystitis
• pneumonia
• conjuntivitis (pink eye)

Question 10

what diseases does parvovirus cause

Answer 10

• Aplastic crisis in cickle cell
• slapped cheeks rash in kids (5th disease)
• hydrops fetalis (RBC destruction in utero)
• rheumatoid arthritis like sxs in adults

Question 11

what dz does polyomavirus cause

Answer 11

JC virus - PML in HIV patients

Question 12

what dz does poxvirus cause

Answer 12

smallpox
cowpox
molluscum contagiosum (flesh colored dimpled lesions

Question 13

MC complication of shingles

Answer 13

post-herpetic neuralgia

Question 14

HHV-3 is called what

Answer 14

VZV

Question 15

HHV4 is called what

Answer 15

EBV

Question 16

HHV5 is called what

Answer 16

CMV

Question 17

HHV6 whats disease

Answer 17

roseola

Question 18

HHV8 whats disease

Answer 18

Kaposi sarcoma

Question 19

What cancers is EBV associated with (3)

Answer 19

Hodgkin lymphoma
endemic Burkitt lymphoma
nasopharyngeal carcinoma

Question 20

high fevers for several days, seizures, followed by diffuse macular rash. what disease?

Answer 20

roseola HHV6

Question 21

CMV complications in aids patients

Answer 21

retinitis - blindness in days

esphagitis

Question 22

CMV appearance in cells

Answer 22

owel eye inclusions

Question 23

HSV2 appearance on tzanck test

Answer 23

multinucleated giant cells with intranuclear cowdry A inclusions

Question 24

high fever, black vomit, jaundice. What virus

Answer 24

yellow fever

Question 25

most important cause of infantile gastroenteritis (virus)

Answer 25

Rotavirus

Question 26

what type of virus is influenza and structure?

Answer 26

orthomyxovirus
enveloped
(-) ssRNA - fast mutating
8 segment genome

Question 27

protein that permits viral entry of flu

Answer 27

hemagglutinin

Question 28

protein that promotes progeny virion release of flu

Answer 28

neuraminidase

Question 29

What are the paramyxoviruses

Answer 29

Parainfluenze - croup (barking cough)
Mumps, measles
RSV

Question 30

what is the major virulence factor of paramyxoviruses

Answer 30

F (fusion protein) - causes epithelial cells to fuse and form multinucleated cells

Question 31

what drug prevents RSV in premature infants

Answer 31

Palivizumab - mAb against F protein

Question 32

Koplik spots and descending maculopapular rash. what virus

Answer 32

measles

Question 33

3 C’s of measles

Answer 33

Cough
Coryza - runny nose
Conjunctivitis

Question 34

3 major symptoms of mumps

Answer 34

makes parotids and testes as big as POM poms

• parotitis
• orchitis (can cause sterility especially after puberty)
• Meningitis

Question 35

Characteristics of rabies virus under microscope

Answer 35

bullet shape

negri (cytoplasmic inclusion bodies)

Question 36

3 structural genes of HIV

Answer 36

env
gag
pol

Question 37

what does env do?

Answer 37

formed from cleavage of gp160

• gp120 - attachment to host CD4+ T cell
• gp41 - fusion and entry

Question 38

what does gag do?

Answer 38

capsid protein (gag on a capsule)

Question 39

what does pol do?

Answer 39

genetic stuff (pol - think polymerase)

• reverse transcriptase
• aspartate protease
• integrase

Question 40

order of HIV binding to receptors

Answer 40

binds CCR5 early or CXCR4 late

Question 41

what does gp41 do

Answer 41

fusion and entry

Question 42

what does gp120 do

Answer 42

attachment to host CD4+ T cell