DNA viruses Flashcards
herpesvirus structure
enveloped linear dsDNA
hepadnavirus structure
enveloped partially ds and circular
adenovirus structure
nonenveloped ds linear
parvovirus structure
nonenveloped ss and linear (-)
papillomavirus
nonenveloped ds and circular
polyomavirus
nonenveloped ds and circular
poxvirus
enveloped ds and linear
Hepadnavirus. whats special and what disease
HBV
- has reverse transcriptase
What dzs does adenovirus cause
- febrile pharyngitis
- acute hemorrhagic cystitis
- pneumonia
- conjuntivitis (pink eye)
what diseases does parvovirus cause
- Aplastic crisis in cickle cell
- slapped cheeks rash in kids (5th disease)
- hydrops fetalis (RBC destruction in utero)
- rheumatoid arthritis like sxs in adults
what dz does polyomavirus cause
JC virus - PML in HIV patients
what dz does poxvirus cause
smallpox
cowpox
molluscum contagiosum (flesh colored dimpled lesions
MC complication of shingles
post-herpetic neuralgia
HHV-3 is called what
VZV
HHV4 is called what
EBV
HHV5 is called what
CMV
HHV6 whats disease
roseola
HHV8 whats disease
Kaposi sarcoma
What cancers is EBV associated with (3)
Hodgkin lymphoma
endemic Burkitt lymphoma
nasopharyngeal carcinoma
high fevers for several days, seizures, followed by diffuse macular rash. what disease?
roseola HHV6
CMV complications in aids patients
retinitis - blindness in days
esphagitis
CMV appearance in cells
owel eye inclusions
HSV2 appearance on tzanck test
multinucleated giant cells with intranuclear cowdry A inclusions
high fever, black vomit, jaundice. What virus
yellow fever
most important cause of infantile gastroenteritis (virus)
Rotavirus
what type of virus is influenza and structure?
orthomyxovirus
enveloped
(-) ssRNA - fast mutating
8 segment genome
protein that permits viral entry of flu
hemagglutinin
protein that promotes progeny virion release of flu
neuraminidase
What are the paramyxoviruses
Parainfluenze - croup (barking cough)
Mumps, measles
RSV
what is the major virulence factor of paramyxoviruses
F (fusion protein) - causes epithelial cells to fuse and form multinucleated cells
what drug prevents RSV in premature infants
Palivizumab - mAb against F protein
Koplik spots and descending maculopapular rash. what virus
measles
3 C’s of measles
Cough
Coryza - runny nose
Conjunctivitis
3 major symptoms of mumps
makes parotids and testes as big as POM poms
- parotitis
- orchitis (can cause sterility especially after puberty)
- Meningitis
Characteristics of rabies virus under microscope
bullet shape
negri (cytoplasmic inclusion bodies)
3 structural genes of HIV
env
gag
pol
what does env do?
formed from cleavage of gp160
- gp120 - attachment to host CD4+ T cell
- gp41 - fusion and entry
what does gag do?
capsid protein (gag on a capsule)
what does pol do?
genetic stuff (pol - think polymerase)
- reverse transcriptase
- aspartate protease
- integrase
order of HIV binding to receptors
binds CCR5 early or CXCR4 late
what does gp41 do
fusion and entry
what does gp120 do
attachment to host CD4+ T cell
