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Drugs > Psych > Flashcards

Psych Flashcards

1
Q

<p>Trifluoperazine</p>

A

<p>1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes

2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic</p>

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2
Q

<p class=”large” style=”text-align:center”;>Fluphenazine</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes

2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic</p>

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3
Q

<p>Haloperidol</p>

A

<p>1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes

2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic</p>

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4
Q

<p class=”large” style=”text-align:center”;>Chlorpromazine</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes

2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), Neuroloeptic malignant syndromey
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic</p>

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5
Q

<p>Thioridazine</p>

A

<p>1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes

2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), Neuroloeptic malignant syndromey
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic</p>

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6
Q

<p class=”large” style=”text-align:center”;>Olanzapine</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s

2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Olanzapine specific: weight gain
4) Fun Facts: </p>

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7
Q

<p>Clozapine</p>

A

<p>1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette's

2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Clozapine specific: weight gain, agranulocytosis and seizures.
4) Fun Facts: Must monitor WBC. Must watch clozapine clozely</p>

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8
Q

<p class=”large” style=”text-align:center”;>Ziprasidone</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s

2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Ziprasidone prolongs QT interval. </p>

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9
Q

<p class=”large” style=”text-align:center”;>Quetiapine</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s

2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.</p>

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10
Q

<p>Risperadone</p>

A

<p>1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette's

2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.</p>

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11
Q

<p class=”large” style=”text-align:center”;>Aripiprazole</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s

2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.</p>

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12
Q

<p>Lithium</p>

A

<p>1) Use: Bipolar, SIADH

2) Class/MOA: Not established. Related to phosphoinositol cascade (?)
3) Side effects/ADEs: Movement, Nephrogenic DI, hypOthyroidism, Pregnancy (LMNOP)
4) Fun Facts: May cause fetal cardiac defects, excreted by kidneys</p>

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13
Q

<p class=”large” style=”text-align:center”;>Buspirone</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Generalized anziety disorder

2) Class/MOA: Stimulates 5-HT1A receptor.
3) Side effects/ADEs: No sedation, addiction or tolerance
4) Fun Facts: No interactions with barbituates or benzodiazepines</p>

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14
Q

<p class=”large” style=”text-align:center”;>Fluoxetine</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias

2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect</p>

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15
Q

<p>Paroxetine</p>

A

<p>1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias

2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect</p>

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16
Q

<p class=”large” style=”text-align:center”;>Sertraline</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias

2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect</p>

17
Q

<p>Citalopram</p>

A

<p>1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias

2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect</p>

18
Q

<p class=”large” style=”text-align:center”;>Venlafaxine</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Depression. Venlafaxine also in GAD, panic disorders.

2) Class/MOA: SNRI, Inhibit serotonin and NE reuptake
3) Side effects/ADEs:Increased BP </p>

19
Q

<p>Duloxetine</p>

A

<p>1) Use: Depression, diabetic peripheral neuropathy.

2) Class/MOA: SNRI, Inhibit serotonin and NE reuptake (greater effect on NE than other SNRI-venlafaxine). Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
3) Side effects/ADEs:Increased BP </p>

20
Q

<p class=”large” style=”text-align:center”;>Amitriptyline</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Major depression, fibromyalgia

2) Class/MOA: 3rd generation tricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: Third generation TCAs have more anticholinergic side effects</p>

21
Q

<p>Nortriptyline</p>

A

<p>1) Use: Major depression, fibromyalgia

2) Class/MOA: 2nd generation tricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: Second generation TCAs have fewer anticholinergic side effects</p>

22
Q

<p>Imipramine</p>

A

<p>1) Use: Major depression, fibromyalgia, bedwetting

2) Class/MOA: Tricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: use for bedwetting is imipramine specific. </p>

23
Q

<p>Desipramine</p>

A

<p>1) Use: Major depression, fibromyalgia.

2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: Less sedating, higher seizure threshold. . </p>

24
Q

<p>Clomipramine</p>

A

<p>1) Use: Major depression, fibromyalgia. First line OCD.

2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb) </p>

25
Q

<p>Doxepin</p>

A

<p>1) Use: Major depression, fibromyalgia.

2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb) </p>

26
Q

<p class=”large” style=”text-align:center”;>Amoxapine</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Major depression, fibromyalgia.

2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb) </p>

27
Q

<p>Tranylcypromine</p>

A

<p>1) Use: Atypical depression, anxiety, hypochondriasis

2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John's wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)</p>

28
Q

<p class=”large” style=”text-align:center”;>Phenelzine</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Atypical depression, anxiety, hypochondriasis

2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)</p>

29
Q

<p>Isocarboxazid</p>

A

<p>1) Use: Atypical depression, anxiety, hypochondriasis

2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John's wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)</p>

30
Q

<p class=”large” style=”text-align:center”;>Selegiline</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Atypical depression, anxiety, hypochondriasis

2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)</p>

31
Q

<p>Bupropion</p>

A

<p>1) Use: Smoking cessation. Depression

2) Class/MOA: Atypical antidepressant. Increase NE/dopamine via unknown mechanism
3) Side effects/ADEs: Toxicity: tachycardia, insomnia, headache, seizures in bulimics
4) Fun Facts: No sexual side effects</p>

32
Q

<p class=”large” style=”text-align:center”;>Mirtazapine</p>

A

<p class=”large” style=”text-align:center”;>1) Use: Depression.

2) Class/MOA: Atypical antidepressant. Alpha2 antagonist (increases NE and serotonin), potent 5-HT2 and 5-HT3 antagonist
3) Side effects/ADEs: Toxicity: sedation, increase in appetite, weight gain, dry mouth
4) Fun Facts: May be used in anorexics due to side effect of weight gain</p>

33
Q

<p>Maprotiline</p>

A

<p>1) Use: Depression.

2) Class/MOA: Blocks NE reuptake.
3) Side effects/ADEs: Orthostatic hypotension, sedation</p>

34
Q

<p>Trazodone</p>

A

<p>1) Use: Depression (at high doses). Insomina primarily.

2) Class/MOA: Atypical antidepression
3) Side effects/ADEs: Sedation, nausea, priapism, postural hypotension
4) Fun Facts: Called trazoBONE due to male specific side effect</p>

Drugs (11 decks)

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