Psych Flashcards
What is psychosis linked to
Over activity of the NT dopamine
Most common condition
Schizophrenia
Delusion: grandeur/persecution
Hallucination: visual, auditory, tactile
Illusions: misperception of external stimuli
What elevates central dopamine concentrations
Cocaine, amphetamine
What levels are elevated in psychotic pt
Hemovanillic acid
Dopamine NT
What meds can induce a psychotic state in pts
Ketamine & Phencylidine
Neuroleptic malignant syndrome s/s & is ass with
High fever, confusion, cramps, diaphoresis, muscle rigidity, coma
Phenothiazine
What drug is used for Tourette’s syndrome
Haldol: acts by inhibiting dopa receptors
Phenothiazine s/e
Hallucinations
Extrapyramidal syndrome: akathisia, tarditive dyskinesia, Parkinsonism
Neuroleptic malignant syndrome
Ortho hypotension
Which psych med leads to impotence, wt gain, and it’s not for young/DM males?
Atypical antipsychotics: Clozapine
Blocks: dopa, serotonin, alpha adrenergic, cholinergic receptors
Associated with severe schizophrenia
What are tricyclics s/e
Muscarinic blockage
Cardio toxicity
Torsade de pointes
Extrapyramidal effects
Serotonin syndrome plus other S/E are of what drug
High temp, confusion, anxiety, HTN, sweating
Sexual dysfunction 70%, impotence
Celexa, Prozac, Zoloft
How phenothiazine work
Act on over active dopamine receptors and block them
65% decrease of psychotic symptoms
What happens with Abrupt d/c of antipsychotic meds
7 days after meds d/c
Anticholinergic rebound: n/v, diarrhea, agitation, insomnia,
Extrapyramidal s/e with clozapine
St. John’s worth
Inhibits what
Fact
Inhibits serotonin uptake
Pain after sun exposure
Lithium facts
Not metabolized High levels in thyroid, bone, brain Narrow therapeutic window Nephrotoxicity, cardiotoxicity N/V are early signs of toxicity
