Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm II, Exam 3 > NSAIDs > Flashcards

NSAIDs Flashcards

0
Q

What creates eicosanoids

A

Arachidonic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Eicosanoids examples

A

Prostaglandin
Leukotriene
Thromboxone
Prostacyclin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

When are the eicosanoids synthesized

A

In response to various stimuli, tissue injury & immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Steps for inflammatory process

A
  1. Inflammatory response activates—-
  2. phospolipase (cell membrane or cytoplasm) release
  3. Arachidonic acid - esterized - Arachidonate metabolized to
    a. Lipooxygenase - leukotriens
    b. Cyclooxygenase - prostaglandin, prostacyclin, thrombaxane
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What r corticosteroids

A

Anti inflammatory cause they inhibit phospolipase A2, reducing Arachidonate release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What leukotriens & lipoxins induce

A

Inflammation & asthmatic constriction of the bronchioles

5-Lipoxygenase (found in leukocyte) —5-HPETE —-leukotriens & lipoxins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What enzyme is in abundance in cancer cells & thought to have a role in producing vascular genesis needed for tumor to grow

A

Lipoxygenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which ones are involved with pathologic effects?

A

PGF2a, thrombaxane A2, & leukotriens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What comprises “slow reacting substance of anaphylaxis”

A

Leukotriens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are some effects of eicosanoids

A 
Protection of gastric mucosa,
Endogenous vasodilation
Smooth muscle relaxation
Labor
Maintaining latency of ductus arteriosus during development & platelet clotting
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Where do effects of eicosanoids occur

A

Platelets, smooth muscle, CNS & other tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Waht is the molecule of the year

A

Nitric oxide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Nitric oxide

A

Messanger
Neurotransmitter
Expressed by inflammatory cells when activated by cytokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What cells produce NO

A

Macrophages produce NO in combating bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the result of NO

A

Vasodilation, increased vascular permeability, & PG release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What happens in the severe infection like sepsis with NO

A

Over production that leads to vasodilation

Also involved in platelet aggregation

16
Q

What do ASA and other no selective drugs inhibit

A

Inhibit all COX activity so prostaglandins needed for normal function are depleted

17
Q

Less effect on prostaglandins

A

COX 2 selective NSAIDs, example Celebrex

18
Q

What does cox 2 inhibitors block/use for

A

Pain
fever
Inflammation

19
Q

Effects of NSAIDs

A
  • Antipyretic
  • Analgesia
  • Anti inflammatory, no effect on tissue damage or immunologic response
  • Inhibition of platelet aggregation
20
Q

Pharmacokinetics of NSAIDs

A
  1. Low first pass extraction
  2. Highly protein bound,
  3. Low vd
  4. Weak organic acid
  5. Metabolized in liver CP 450, kidney some biliary
21
Q

What is the safest NSAID for renal pt

A

ASA

22
Q

What is the diagnostic test for coagulation issues with NSAIDs

A

Bleeding time NOT platelet count

23
Q

Can u reverse ASA

A

NO, effects last life of the platelet 7-10 d
Other NSAIDs can be reverse

ASA nonselective COX inhibition

24
Q

Cardiovascular effects of NSAIDs

A

COX 2 inhibitors are ass with inc risk of stroke & MI

Cox 2 - protective affect of estrogen in preventing plaque & sclerosis.

25
Q

Drug interactions of NSAIDs

A

NSAIDs +

  1. Anticoagulants = incr risk of bleeding
  2. K sparing diuretics = hyperkalemia
  3. Decreased effect of HTN meds
  4. Antidepressants - decrease lithium levels, interfere w/SSRIs
26
Q

Do opiates or NSAIDs have ceiling effect

A

NSAIDs

27
Q

What is ASA hydrolyzed to

A

Salicylate in GI, an active enzyme

28
Q

Is ASA reversible

Safe for what pt population

A

NO, life of the platelets 7-10 days

Renal, nonselective COX inhibitor

29
Q

How is the absorption of NSAIDs effected

A

Decreased by: presence of food & increased ph ( inc ionization)

30
Q

What is the magic drug

A

Acetylsalicylic acid derived from acetylation of salicylic acid

ASA

31
Q

What is the 1/2 life of ASA & salicylic acid

A

ASA is 15-20 min

Salicylic acid 2-3 hrs, prolong effect of ASA

32
Q

ASA use

A
  1. Pain
  2. Antipyretic
  3. Antiplatelet
  4. Angina & acute MI
33
Q

Which med has correlation with Reye’s syndrome

A

ASA

34
Q

ASA doses

A
  1. Low dose: Antiplatelet 2400 mg/day
35
Q

Ofirmev doses

A

1000 mg q6 hr. or 650 mg q 4 hrs MAX 4 g/day
Give infusion over 15 min
100 ml amp, 10 mg/ml

36
Q

When is Tordol contraindicated, what pt

A
  1. L&D due to adverse effect on fetal circulation & inhibition of contraction
  2. Present in breast milk
  3. Not for epidural/intrathecal us
37
Q

Ketorolac doses

A

Onset: 65 y.old

38
Q

Does tordol have ceiling effect

A

Yes, just like all NSAIDs

No effect on MAC

Pharm II, Exam 3 (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions