Psych Flashcards

1
Q

Approach to treatment of mental health issues in pregnancy

A
  • The potential benefits of psychological interventions and psychotropic medication
  • The possible consequences of no treatment
  • The possible harms associated with treatment
  • What might happen if treatment is changed or stopped, particularly is medication is stopped abruptly
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Definition of perinatal mental health

A

time from conception to one year postpartum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Routine screening/ RANZCOG recommenddations for mental health issues

A

Routine screening recommended at every AN and PN visit (with Edinburgh Postnatal Depression Scale)
Screen for psychosocial risk factors (ANRQ3)
Early intervention produces the best outcomes for mothers and their families
Awareness of systemic inadequacies
- Poor communication
- Lack of continuity of care
- Non-collaborative models of care
Give advice on lifestyle issues and sleep
Care should be culturally responsive and family-centred
Treatment offered should involve collaborative decision-making with the woman and her partner

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Red flags for mental health assessment

A

Recent or rapidly changing significant alterations in mental state
Emergence of new symptoms
- Psychotic symptoms (delusions, hallucinations)
-Severe anxiety in relation to infant’s / children’s welfare
Psychotic symptoms that involve the infant
Acts of violent self-harm or suicide
New / persistent / non-reassurable ideas and expression of these ideas, where the woman believes she is incompetent / inadequate as a mother or feels estranged from her infant
Pervasive guilt and hopelessness
Deterioration in function as a consequence of symptoms, e.g. self-care, care of the infant, avoidance of the infant
Not eating
Severe insomnia
Psychomotor retardation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Indications for referral for maternal mental health

A

Current illness with psychosis, severe anxiety, severe depression, suicidality, self-neglect, harm to others or significant interference with daily function
Hx of BPAD or schizophrenia
Previous serious PP mental illness
Complex psychotropic medication regimens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Suicide

A

Risk is highest in:
- Late pregnancy and first 12/52 PP
- Those with early-onset serious mental illness
- Hx of previous mental illness
In those with puerperal psychosis, risk of suicide in 2 per 100
Methods of suicide in this period are more likely to be violent than outside this period

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Anorexia nervosa and pregnancy

A
Highest mortality of all psychiatric conditions 
6-fold increase in perinatal mortality
Increased rate of fertility problems 
Common in young women
Remission rates are high in pregnancy
Support postpartum
- Feeding difficulties are common
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Incidence of perinatal mental health issues

A

Up to 80% of mothers experience the ‘baby blues’
10% of Australian women experience AN anxiety and/or depression
- 16% experience PN
10% of fathers affected
3-5% of women severely affected and require secondary care services

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Baby blues / postnatal blues

A

3-5 days after giving birth (peaks day 5)
Transient, self-limiting
Usually dissipating within 10 days
Tearfulness, anxious, irritable
- Mild hypochondriasis
Affects primiparous and multiparous women equally
Cause - probably combination of psychosocial factors and hormonal factors
- Studies have found higher progesterone and oestrogen levels in women with PN blues, but cortisol levels similar
- Prolactin levels may be higher in women with PN blues
Sleep and rest improve symptoms of PN blues - discuss reducing visitors
Involve / inform family
Reassure and safety net - Screen women for resolution day 10-14 PN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Impact of depression on pregnancy

A

Detrimental effects on fetal and infant development and on mother infant attachment
Of women identified with AN or PN depression, 50-70% of those untreated remain depressed 6 months later
25% of women will develop a chronic illness
25% will develop recurrent depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Aetiology / definition of PND (post-natal depression)

A

Any non-psychotic depressive illness occurring in the first PN year
Thought that 1/3 of those diagnosed have symptoms starting antenatally
Risk of relapse is higher in those who stop their medication
Pregnancy is not a protective factor in relapse from mental disorders
Gradual onset in first 2 weeks
2 peak presentations:
- 2-4 weeks PN
- 10-14 weeks PN
Prognosis is good
High risk of recurrence in future pregnancies (1 in 2 to 1 in 3)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Risk factors of PND

A
History of mental health problems
FHx of PN depression 
Lack of support
Previous trauma - physical, emotional or sexual abuse
Isolation - physical, mental, cultural
Stressful life events
History of drug or alcohol abuse
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Edinburgh Postnatal Depression Scale (EPDS)

A
10-item questionnaire 
AN and PN use 
Sensitivity 34-100%
Specificity 44-100%
Goal to identify women who require further assessment, not to diagnose depression

If EPDS 10-12, monitor and repeat 2-4 weeks later
If >12, arrange further assessment as it may suggest a crisis
PPV 57%, NPV 99%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Depression screening questions (Whooley questions)

A
  1. During the past month, have you often been bothered by feeling down, depressed or hopeless?
  2. During the past month, have you often been bothered by having little interest or pleasure in during things?
  3. Is this something with which you would like help?
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Diagnostic and Statistical Manual of Mental Disorders (DSM IV)

A

Women must exhibit >5 symptoms for >2 weeks with >1 symptom from the first two symptoms listed:
- Depressed mood
- Anhedonia
- Significant change in weight or appetite
- Markedly increased or decreased sleep
- Psychomotor agitation or retardation
- Fatigue or loss of energy
- Feelings of worthlessness or guilt
- Reduced concentration
- Recurrent thoughts of death or suicide
Must be accompanied by significant impairment capacity to engage and function in usual activities, e.g. parenting, occupational, social and other roles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Risks of untreated depression to fetus

A
  • Some studies found associated with miscarriage, lower gestational age, lower infant birthweight
  • Lower APGAR scores, PET, NICU admissions, breastfeeding initiation
17
Q

Risk factors and incidence of PTSD from birth

A

Reported to occur in 2-3% of women after childbirth

  • Those who have suffered previous trauma (DV, rape, childhood sexual abuse)
  • Those with risk factors for perinatal mood disorder
  • Those who perceived that their birth experience was traumatic
18
Q

Tocophobia

A

Morbid dread and fear of pregnancy and the birthing process
Primary tocophobia - in those with no previous experience of pregnancy
Secondary tocophobia - develops after a traumatic obstetric event in a previous pregnancy
History of sexual assault may be associated with an aversion to routine obstetric care associated with primary tocophobia

19
Q

General principles for treating mental health stuff

A

Consider risk-benefit analysis for both the woman and the fetus / infant
Psychological interventions should be maximised to avoid unnecessary drug exposure
Use psychotropic medication with the lowest drug-risk profile
Polypharmacy should be avoided
Some medications require dose adjustments owing to the physiological changes (e.g. increased plasma volume, increased renal excretion)

20
Q

Pre-conception counselling for meds in pregnancy

A

Discuss reasons for stopping
- If high risk of relapse, abruptly stopping medication is usually unwise
Consider restarting or switching to another medication
Offer psychological interventions
Consider increasing the level of monitoring and support
Ensure she is aware of the risks of stopping medication to both herself and the fetus / infant
Stopping or switching the medication after pregnancy is confirmed may not remove the risk of fetal malformations if known teratogen
Offer screening

21
Q

SSRI Neonatal Behavioural Syndrome - aka Newborn Adaption syndrome

A
Jitteriness and respiratory distress
At wort persistent pulmonary HTN
- Absolute risk very small (1.2-3 per 1000 for SSRI)
GI
Onset 1-2 days PP
Lasting up to 10 days
Usually mild
22
Q

SSRI - examples, impact on pregnancy and breastfeeding

A

Sertraline, citalopram

? Small risk of cardiac defects - not consistent in studies. Don’t use paroxetine first line as small increased risk.
No clear increased risk of significant PTB (3 days), IUGR (75g)
No increased risk of miscarriage, HTN

Untreated depression and anxiety is a/w poor outcomes

Risks - neonatal withdrawal

Safe in breastfeeding
<5% of maternal level, often undetectable

23
Q

SNRI - examples, impact on pregnancy and breastfeeding

A

Category B2

No increased risk of congenital malformations

Increased risk of PPH
Venlafaxine may increase risk of PET and PPH

Same as SSRI
Data inconsistent
Any risks are probably small

Appear to be safe to use in breastfeeding, but infant exposure appears to be greater with venlafaxine than for other anti-depressants

24
Q

Tricyclic anti-depressants - examples, impact on pregnancy and breastfeeding

A

Category C

Amitriptyline, desipramine, imipramine, nortriptyline

Have not been shown to be clearly associated with miscarriage or congenital malformations

Level in breastmilk appears low
Nortriptyline favoured if TCA started during lactation due to safety record

25
Q

Benzodiazepines

A

Primary concern = withdrawal
Sedation
If required, low dose of drugs with short half-life and no active metabolites
Risk of PNAS

Consider for moderate to severe anxiety which awaiting onset of SSRI or TCA

26
Q

Lithium
Risks
monitoring

A
Increased risk of Ebstein's anomaly
	- Magnitude of risk remains contentious
	- Congenital heart defect - septal and posterior leaflets of the tricuspid valve are displaced towards the apex of the right ventricle 
Absolute risk is still low
Increased risk of PNAS

Don’t offer if planning pregnancy or pregnant
Increased risk of relapse if drug stopped during pregnancy, especially if abruptly

Therapeutic range is narrow and regular monitoring is required (changing plasma volumes)
Measure every 4 weeks, then weekly from 36/40

27
Q

Signs of lithium toxicity

A

Toxicity if >1.2 mmol/l

  • N/v, cramping, diarrhoea
  • Neuromuscular signs - tremulousness, dystonia, hyperreflexia, ataxia
  • Cardiac dysrhythmias (rare)
  • ECG: T wave flattening
28
Q

Lithium intrapartum and postpartum

A

Withhold during labour and childbirth due to higher placental transfer rates –> adverse fetal outcomes (low Apgar, longer hospital admissions, higher rates of CNS and neuromuscular complications)
Check levels 12h postdose post delivery

High levels excreted in breast milk therefore not advised

29
Q

Antipsychotics - two groups

A

First generation - Chlorpromazine, haloperidol
- Not selective and block dopamine receptors along several neural pathways –> unwanted side effects

Second generation - Clozapine, risperidone, olanzapine, quetiapine

  • More selective dopamine antagonists and have serotonergic properties
  • In general, associated with fewer side effects
30
Q

Antipsychotics - maternal and fetal effects

A

Maternal adverse effects
- Sedation, weight gain, metabolic syndrome (including GDM and hyperprolactinaemia)
- Prolactin levels should be measured if taking a prolactin-raising antipsychotic medication (risperidone) and planning a pregnancy
○ Raised levels reduce chances of conception
- Extrapyramidal side effects - akathisia, dystonism, parkinsonism, tremor

Fetal adverse effects

  • Limited dated
  • May be increased risk of congenital malformations
  • Some studies found increased risk of SGA, GDM, PTB, CS
  • Neonatal adaptation syndrome is commonly observed
31
Q

Define and incidence of puerperal psychosis

A

Definition: an episode with an acute onset characterised by mania with psychotic symptoms that occurs in the early postpartum period
Psychiatric emergency
1 in 1000 women

32
Q

Risk factors for puerperal psychosis

A
Close family member with the condition
Hx of BPAD 
- 1 in 5 (20-30%) chance of developing puerperal psychosis 
75% risk of develop PP psychosis if FHx of the condition in first degree relative and Hx of BPAD
Previous episode of PP psychosis (>50% risk)
Schizoaffective disorder
Discontinuation of mood stabiliser
FHx of BPAD
Mother or sister who had PP psychosis
Primiparity
Obstetric complications
Sleep deprivation
Increased environmental stress
Lack of partner support
33
Q

Signs and Symptoms of postpartum psychosis

A

First signs can be nonspecific - Insomnia, agitation, odd behaviour
Progression is often rapid (within hours) - kaleidoscopic presentation
Hallucinations, delusions, fear, perplexity, confusion, agitation
- Up to 78% have delusional ideas about their infant
More likely to have manic symptoms
- Mood lability, pressure speech, distractibility

Onset - first 2-4 weeks
- 50% by day 7
Symptoms may begin in labour 
Management with 1:1 care while awaiting psychiatric assessment if suspected 
Risk of infanticide and suicide
34
Q

Treatment - postpartum psychosis

A

1:1 care - risk of suicide 2 in 100
Urgent (within 4h) assessment by senior psychiatrist
Hospital admission
Consider wellbeing of infant and other children at home
Mood stabilising medications and antipsychotic medications
Breastfeeding avoided in those on lithium
ECT is well tolerated and rapidly effective

35
Q

Prognosis - postpartum psychosis

A

With the correct treatment, the short-term prognosis is generally good
High risk of recurrence - up to 50%
35-65% will develop BPAD
Offer prophylactic admission to mother and baby unit in next pregnancy

36
Q

BPAD

A

Affects ~1% of the population
Mean age of onset 17-22 years

Relapse more likely following childbirth
- 50% chance of mood episode in PN period, including depression
- Sleep loss may be a contributor to the development of manic episodes
Particularly high risk of suicide in the first year postnatal

Have a clear postnatal plan to minimise risk of relapse
Minimise sleep deprivation
Avoid breastfeeding if on lithium