Post-partum care Flashcards

1
Q

Physiology of post-partum

A

Uterine involution
- 10-14 days after delivery fundus should not be palpated abdominally
Internal os of cervix closed by 48h postpartum
Duration of lochia is variable
Fall in oestrogen causes atrophy of lower genital tract
Decreased secretions from glandular tissue
Ligament laxity resolves as progesterone and relaxin levels reduce
Divarication of the rectus abdominus muscle is common
Pulse rate and CO return to pre-pregnancy level by 6 weeks PP
Diuresis (3rd day PP) –> reduction in plasma volume –> increase in Hb levels

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2
Q

Cochrane - early skin-to-skin associated with:

A

Increased likelihood of breastfeeding in the first 1-4 months and increased breastfeeding duration
Less infant crying
Increased infant interaction with their mother
No harmful or negative outcomes

WHO recommends skin to skin immediately after birth for at least 1-2h
As little as 15-20 mins can be beneficial

Improves thermal regulation in the neonate and facilitates mother infant attachment

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3
Q

Incidence of PPH

Define

  • major
  • primary
  • secondary
A

incidence 5-15%

Major / severe PPH
>1000ml, complicates 1-5% of deliveries

Primary PPH - Within 24h of delivery

Secondary PPH - Between 24h and 6 weeks postpartum
Incidence 0.47% to 1.44%

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4
Q

Total blood volume at term

A

~100ml/kg
- Maternal blood volume may be approx 7L for a 70kg woman

Blood flow to the placental bed is approximately 750ml/min at term

Blood loss may be life-threatening with unreplaced volume loss of as little as 30%

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5
Q

Risk factors for atony

A
Uterine overdistension
Increasing parity
Functional or anatomical distortion of the uterus
- Prolonged labour
- Precipitous labour
- Fibroids 
- Uterine anomalies
- Placenta praevia
Intra-amniotic infection (chorioamnionitis)
Oxytocin withdrawal
Instrumental birth
Uterine relaxants
Previous PPH - 3-fold increase
IOL 
Iron deficiency anaemia
Bladder distension
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6
Q

Prevention of PPH

A

Active management of third stage with prophylactic oxytocics and CCT

  • Reduce risk of PPH by at least 50%
  • Cochrane review - reduction of 68%
  • Majority of PPH cases occur in the absence of known risk factors
  • Physiological third stage cannot be recommended
  • CCT should only be applied once uterus is well contracted and the placenta is separated

Uterine massage is of no benefit in the prophylaxis of PPH
Treat anaemia / iron deficiency antenatally
Determine placental site at anatomy scan
Fetal pillow for second stage CS - reduces the risk of uterine extension

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7
Q

With prophylactic uterotonic

A

Women without risk factors delivering vaginally - Oxytocin 10 iu IM

Women delivering by CS- Oxytocin 5 iu slow IV injection

Women with increased risk of PPH - Ergometrine-oxytocin

Women with increased risk of PPH, delivering by CS - Consider IV TXA

Meta-analysis compared oxytocin 5IU, 10 IU and syntometrine

  • Similar efficacy in preventing PPH >1000ml
  • Syntometrine associated with small reduction in risk of PPH of >500ml
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8
Q

Oxytocin

  • dose
  • mechanism of action
  • pros and cons
A

Direct relaxant effect on vascular smooth muscle
Structurally similar to vasopressin –> antidurectic effects

Caution if possibility of undiagnosed second twin (no USS in pregnancy) when using for active management

Adverse effects:

  • Rapid IV bolus can cause profound hypotension, esp if hypovolaemia
  • Antidiuretic effects can lead to water intoxication and hyponatraemia
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9
Q

Ergometrine

  • dose
  • mechanism of action
  • pros and cons
A

Syntometrine 1ml IM = oxytocin 5 units/ml + ergometrine 500mcg/ml

Alpha-adrenoceptor and dopamine receptor agonist –> strong sustained uterine contractions
Causes vasoconstriction

Contrainidcation:

  • Hypertension
  • Severe cardiac disease

ADR:
5-fold risk of adverse effects over oxytocin
Nausea and vomiting
HTN

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10
Q

Misoprostol

  • dose
  • mechanism of action
  • pros and cons
A

Less effective than oxytocin
Cheap, stable, can be used in under-resourced countries

ADR:
GI disturbance
Dizziness
Headache
Fever
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11
Q

Carboprost

  • dose
  • mechanism of action
  • pros and cons
A

0.25mg IM

Synthetic prostaglandin
Used when ergometrine is contraindicated or ineffective
Can repeat dose at 15 min intervals until total 2mg

Contraindications:

  • Asthma
  • Cardiac disease
  • Pulmonary disease
ADR:
Bronchospasm
Vasodilation
HTN
Increased risk of infection
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12
Q

Retained placenta

  • incidence
  • risk factors
A

3% of vaginal deliveries

Retained placenta diagnosed after:

- 1 hr of physiological management
- 30 mins of active management

Causes and risk factors:

- Full bladder
- Atony
- Previous uterine scar
- Fibroid uterus
- Other uterine abnormality
- Cervical constriction ring
- Placenta accreta spectrum
- Umbilical cord snapping
- Premature birth
- Stillbirth 

Associated with recurrence

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13
Q

Secondary PPH

A

Causes:

  • Endometritis
  • RPOC
  • Subinvolution of the placental implantation site
  • Rarely: Pseudoaneurysm, AVM

10% present with massive haemorrhage and require immediate attention

ERPOC associated with 1.5% risk of perforation

41% occur - 8-14 days

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14
Q

Balloon tamponade

for PPH

A

No clear evidence for duration to remain in
Tamponade controls atony in upper segment and placental bed bleeding in lower segment
Bakri balloon - usually requires 300ml saline, but has capacity for 500mls
In most cases 4-6 hours should be adequate to achieve haemostasis
- Most units 12-24h
Remove during daytime hours
Cover with antibiotics

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15
Q

Haemostatic brace suture for PPH

A

75% success in avoiding hysterectomy
B-lynch requires hysterotomy
Absorbable suture with large needle
Hayman suture (2 separate sutures)

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16
Q

Risk factors and common presentation of Sheehan syndrome

A

Risk factors:

- PPH
- T1DM
- Sickle cell disease

Common presentation:

- Failure to lactate post-delivery
- Amenorrhoea or oligomenorrhoea 

Can present with any of the manifestations of hypopituitarism, e.g. hypotension, hyponatraemia, hypothyroidism

If patient remains hypotensive after control of haemorrhage and volume replacement, evaluate and treat for adrenal insufficiency immediately
Evaluate for other hormone deficiencies at 4-6 weeks post-partum

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17
Q

Risk factors for uterine inversion

A
  • Accreta
  • Fundal placental insertion
  • Any condition that predisposes to atony and prolapse
  • CCT without countertraction in an uncontracted uterus
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18
Q

Management of uterine inversion

A

Goals:

  • Replace the fundus to correct position
  • Management PPH and shock
  • Prevent recurrent inversion

Discontinue uterotonic drugs
Do not remove the placenta
- Do after uterus is replaced as likely will increase blood loss
Immediately attempt to manually replace the inverted uterus - Johnson manoeuvre
- Once reverted, keep hand in uterus, and restart oxytocin
Transfer to OT for manual removal

If unstable after initial attempt, reasonable to proceed to laparotomy
If haemodynamically stable
- GTN
- Terbutaline

Can try hydrostatic pressure

Prevent recurrent inversion:

  • Uterotonic meds
  • Hold uterus in place
  • Prophylactic antibiotics

Documentation
Debrief

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19
Q

Perineal tear classification

A

1st degree = Injury to perineal skin and/or vaginal mucosa only
2nd degree = Injury to perineum involving perineal muscles but not anal sphincter
3rd degree = Injury to perineum involving anal sphincter complex

3A <50% of EAS torn
3B >50% of EAS torn
3C Both EAS and IAS torn

4th degree = Injury to perineum involving anal sphincter complex and anorectal mucosa

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20
Q

Preventing perineal trauma

A
Cochrane 2017
- Hands off vs. hands on - no difference
- Reduction in OASIS:
	○ Warm compresses during second stage
	○ Perineal massage during antenatal period (last month of pregnancy) - May also be beneficial in second stage 
- Further research needed

Evidence for the protective effect of episiotomy is conflicting
There is evidence that a mediolateral episiotomy should be performed with instrumental deliveries as it appears to have a protective effect on OASIS

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21
Q

Benefits of rapid absorbable suture for tear repair over standard synthetic absorbable

A

Reduced analgesia up to 10 days postpartum
Less suture material removal required
Increased superficial partial skin gaping
No difference in longer term outcomes

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22
Q

Continuous vs. interrupted

for perineal tear

A

Cochrane review
Continuous for all layers:
- Reduction in short term pain
- Reduction in suture removal

Continuous suture for skin:
- Reduction in analgesia
No difference in long term pain or need for resuturing

23
Q

Episiotomy should be considered where…

A

there is a high likelihood of severe laceration

Soft tissue dystocia
Requirement to accelerate birth of a compromised fetus
Need to facilitate operative vaginal birth
History of FGM

24
Q

Incidence of OASIS

A

UK incidence: 2.9% (range 0-8%)
Primiparae 6.1%
Multiparae 1.7%

25
Risk factors for OASIS
However RF do not allow accurate prediction of OASIS ``` Nulliparity Asian ethnicity Birthweight >4kg OP position Shoulder dystocia Prolonged second stage Instrumental delivery - Ventouse without episiotomy OR 1.89 - Ventouse with episiotomy OR 0.57 - Forceps without episiotomy OR 6.53 - Forceps with episiotomy OR 1.34 ``` Midline episiotomy
26
OASIS repair technique
Cochrane - at 1y f/u, overlap had reduced incontinence and urgency - at 36/12 - no difference Anorectal mucosa repair - 3/0 vicryl (cont or interrupted) IAS - 3/0 PDS interrupted or mattress without any attempt to overlap the IAS EAS 3-0 PDS: - 3C - either overlapping or end-to-end technique - 3A or 3B - end-to-end technique
27
Post-op management of OASIS
Document Broad-spectrum antibiotics - reduce the risk of post-op infections and wound dehiscence Bladder catheterisation Analgesia Diet Laxatives - associated with earlier and less painful BM and early postnatal discharge - To reduce the risk of wound dehiscence Physiotherapy GOPD follow up 6-12 weeks post-natal - Manometry - Endosonography
28
6 week review for OASIS
Review symptoms - 60-80% will be asymptomatic Consider investigations - Anal manometry - balloon in rectum which is inflated to check the muscle function of the IAS/EAS - Endoanal USS - looks for defect in the muscle Referral to General Surgeons if symptomatic or abnormal investigations - If family complete would recommend secondary sphincter repair Non-surgical management - dietary advice - egulate bowels - Constipating agents e.g. loperamide - Pelvic floor exercises and biofeedback 5-7% risk of sustaining another OASIS tear - 17% of women will develop worsening faecal symptoms If symptomatic --> c-section If chooses vaginal birth then hands on delivery with experienced practitioner Role of episiotomy in next pregnancy unclear - should have episiotomy if clinically indicated
29
Risk factors for recurrent OASIS in subsequent pregnancy
Asian ethnicity Forceps delivery Birthweight >4kg
30
Anatomy of the breast
Contain mammary glands which produce milk Breasts composed of glandular tissue and fatty tissue Cooper's ligaments - anchor's breast tissue to chest wall 15-25 lobes arranged radially with interposed fat Composed of lobules and alveoli - alveoli synthesise milk Each alveoli has a draining duct Contractile unit made up of myoepithelial cells which eject breastmilk into ducts Each alveoli is drained by a duct which joins to form a single large duct for each lobe Lacteriferous duct open separately on the nipple Areola / Montgomery glands secrete lipoid fluid which moisturisers the nipple and also has a scent to attract baby
31
Blood and nerve supply of the breast
Blood supply from the internal mammary and lateral thoracic arteries Innervated by the intercostal nerves of the 4th and 5th intercostal spaces
32
Lactogenesis
Lactogenesis I: - Human placental lactogen --> breast growth - Begins at 15-20/40 - breast develops capacity to secrete milk components - Prolactin stimulates mammary cells to produce milk, nipple growth - High levels of progesterone inhibit lactation - Mammary fat pads decrease in size and are replaced by developing ducts and alveoli Lactogenesis II: - Onset of copious milk production - Begins 30-40h after birth, complete by day 8 PP - Delivery of placenta --> rapid drop in progesterone and estrogen --> increased levels of prolactin --> breast milk biosynthesis Lactogenesis III: - Maintenance of milk production - "Supply and demand"
33
WHO's baby friendly initiative and 10 steps to successful breastfeeding
1. Having a written breastfeeding policy that is routinely communicated to all health care staff 2. Training all health care staff in skills necessary to implement this policy 3. Informing all pregnant women about the benefits and management of breastfeeding 4. Helping mothers initiate breastfeeding within a half hour of birth 5. Showing mothers how to breastfeed, and how to maintain lactation even if they should be separated from their infants 6. Giving newborn infants no food or drink other than breastmilk, unless medically indicated 7. Practicing rooming in - allowing mothers and infants to remain together 24h a day 8. Encouraging breastfeeding on demand 9. Discouraging the use of artificial teats or pacifiers in breastfeeding infants 10. Fostering the establishment of breastfeeding support groups and referring mothers to them on discharge from the hospital
34
The value of breastfeeding - for infants
Decreased infant mortality Enhanced immunity and decreased risk and severity of infections Decreased risk of asthma, eczema and allergies Decreased risk of SIDS Decreased risk of obesity, diabetes, hypercholesterolaemia Enhanced cognitive development Decreased risk of childhood cancers Decreased risk of certain chronic diseases
35
The value of breastfeeding - for mothers
Enhanced psychological bonding Decreased PP bleeding and rapid uterine involution due to the action of oxytocin Decreased risk of breast, ovarian and endometrial cancer Earlier return to pre-pregnancy weight
36
Causes of decreased milk supply
``` RPOC PPH Maternal diabetes Hormonal issues - Hypopituitarism - Sheehan's syndrome - Thyroid disease Stress Inadequate or infrequent nipple / breast stimulation Separation from infant Medications Anatomic issues, e.g. previous breast surgery Systemic infection Mother-infant separation CS ```
37
Management of low supply
``` Assess attachment Increase feeds including waking infant Express Increase skin to skin time Domperidone - Acts by increasing prolactin ```
38
Breast engorgement
May occur within first few days of established breastfeeding Result of interstitial oedema, increased blood flow and accumulation of milk in the breast Usually bilateral pain, redness, hardness of breasts As for low supply - check position and attachment - If above current, then express for comfort Treat by unlimited, frequent feeding
39
Lactational Mastitis
Flu-like symptoms, rigors, red and tender breasts May be localised area of tenderness = blocked milk duct If symptoms persist more than a few hours after management for blocked duct, evaluate ? infective mastitis (Symptoms do not improve, or are worsening, after 12-24h despite effective milk removal) Only 4% of mastitis is infective
40
Blocked duct
``` Causes build up and inflammation Tender and palpable lump Management: - Encourage mother to feed on affected side first - Position infants chin towards blockage - Massage when feeding / expressing - May progress to mastitis ```
41
Risk factors for mastitis
``` Poor breastfeeding technique Failure to alternate between breasts - Can cause nipple fissures, cracks (inconclusive evidence), sores Not wearing a well-fitting maternity support bra Abrupt discontinuation of breastfeeding Past history of mastitis Primip Maternal fatigue ``` ``` Infrequent or interrupted feeding Mixed bottle and breastfeeding Delayed initiation of feeding Time limited feeds Incomplete emptying Late shift from colostrum to milk production ```
42
Incidence of mastitis | and common pathogens
Acute mastitis in 2-3% of postpartum women Lactation mastitis in 10-33% Breast abscess in untreated mastitis is ~3% Common pathogens: - Staphylococcus aureus - Staphylococcus epidermidis If recurrent - mixed flora including anaerobes Beta haemolytic strep A B F Haemophilus influenzae E. Coli
43
Physiological changes in pregnancy affecting CPR
Difficult to intubate - breast enlargement, laryngeal oedema, weight gain --> Secure airway early High risk of aspiration - reduced oesophageal tone, raised intra-abdominal pressure from gravid uterus, decreased gastric motility --> Secure airway early, PPI in labour Rapid development of hypoxia - dilutional anaemia, reduced FRV from increased minute ventilation and diaphragm splinting, increased O2 consumption from uteroplacental unit --> Give early, high-flow O2 Chest compressions more difficult - breast hypertrophy and a raised diaphragm --> decreased chest wall compliance Reduced venous return and CO by 30-40% --> Do uterine displacement for CPR Predisposition to haemorrhage and hypovolaemia --> Aggressive fluid resuscitation Dilutional anaemia - Plasma volume increased by up to 50% in pregnancy --> Treat anaemia antenatally
44
Stages of DIC
Stage 1 = Hypercoagulable state - Activation of clotting factors and development of microthrombi Labs: decreased clotting, increased platelet adherence Stage 2 = Consumptive hypercoagulable state - Increased consumption of platelets and clotting factors --> bleeding Labs: Increased clotting, decreased platelets and fibrinogen Stage 3 = Secondary fibrinolytic state - Substantial formation of fibrin degradation products and plasmin --> Marked bleeding Labs: Increased thrombin time, decreased clot lysis time, increased fibrin degradation products
45
Perimortem C-section
Should be carried out within 4 mins or as soon as possible after loss of spontaneous circulation in gestations >20/40 12-15% of circulating blood volume at term supplies the uterus Trigger the massive obstetric haemorrhage protocol in an undelivered woman at the time the decision to proceed with peri-mortem CS is made Delivery should be achieved within 5 mins of cardiac arrest - Maximises maternal survival and reduces risk of long-term neurological impairment
46
AFE diagnosis
Clinical diagnosis of acute hypotension or cardiac arrest, acute hypoxia and coagulopathy in the absence of any other potential explanation Or diagnosed on post-mortem with presence of fetal debris in the pulmonary circulation
47
AFE Incidence
5.4 cases per 100,000 women giving birth (Au/NZ) Case fatality rate of 15% If the AFE occurs in utero, neonatal mortality up to 40%
48
Pathophysiology | of AFE
Poorly understood Amniotic fluid enters maternal circulation via breach of barrier between maternal circulation and intact fetal membranes Immune-mediated mechanisms suggested Anaphylactic type reaction Obstruction to pulmonary vessels Complement activation - clotting problems
49
Risk factors | of AFE
``` Given low incidence, no change to clinical practice warranted AMA Placenta praevia Placental abruption Operative delivery Caesarean section Polyhydramnios IOL Trauma Multiple gestation Multi parity ```
50
Anaphylaxis presentation / pathophys
Rapidly developing Airway, breathing, circulation problem - Significant intravascular volume redistribution --> decreased CO - Acute ventricular failure and myocardial ischaemia can occur - Upper airway obstruction from angioedema, bronchospasm, mucous plugging of smaller airways Skin signs present in up to 90%
51
Management of anaphylaxis
Remove trigger Call for help Lay patient flat with legs raised to combat vasodilation effects on circulation, unless prominent upper airway swelling 0.5ml (0.5mg) adrenaline 1:1000 IM at 5 minute intervals STAT fluids High-flow oxygen Support with antihistamine and hydrocortisone Blood tests for tryptase level - Start of event, at 1 hour, and at 24h Some patients can have a biphasic reaction so monitor for at least 6 hours
52
Management of toxicity of MgSO4
calcium gluconate (10mls of 10%)
53
Causes of cardiac arrest
4 Hs and 4 Ts - Haemorrhage - Hypoxia - Hypo/hyperkalaemia - Hypothermia - Thromboembolism - Toxicity including sepsis - Tamponade - Tension pneumothorax Also intracranial haemorrhage and eclampsia
54
RANZCOG management considerations | for PPH
1. Recognition 2. Communication and teamwork 3. Resuscitation 4. Monitoring and investigation 5. Management of PPH