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Dermatology Module > Psoriasis > Flashcards

Psoriasis Flashcards

1
Q

impt features of Psoriasis (4)

A
  • Non-contagious - Inflammatory skin disease - +/- nail involvement - chronic, without cure
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2
Q

Prevalence in PGH

A

5.5%

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3
Q

onset age

A

15-30

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4
Q

Triggers

A

stress trauma infection Drugs- antimalarials cold weathers sunlight obesity smoking

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5
Q

genetic factors

A
  1. HLA Cw6 2 B13 3 B27
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6
Q

what does naive T - cells do?

A

differentiate Th1 and Th17

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7
Q

Features of autoimmune disease in psoriasis

A
  1. Autoantigen 2. STreptococcous Ag
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8
Q

Pro-inflammatory cytokines produced

A

Il-2, Il-17,IL-22,Tnf-a,IFNy

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9
Q

Keratinocyte kinetics in Psoriasis

A
  1. Proliferative cell population (2x of normal, increase) 2. Cell cycle duration (10% of normal, faster) 3 Epidermal transit time (15% of normal
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10
Q

features of blood vessel in Psoriasis

A

tortuous (causes auspitz sign)

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11
Q

Auspitz sign

A
  1. Bleeding upon removal of scales (thinned suprapappilary plate) 2. not always present
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12
Q

Koebner Phenomenon

A

-Traumatic induction of psoriasis of non-lesional skin - NAP -Isomorphic response of skin on lines of trauma

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13
Q

identify / with characteristics

A
  • Called a plaque
  • Most common
  • extensor surfaces
  • psoriasis vulgaris
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14
Q

morphological variant (name,characteristics)

A
  • Guttate
  • Drop-like plaqus with finner scales
  • associated with prior streptococcal infection, children and adolescents
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15
Q

name and characteristics (name 2 variants and special feature in pregnancy

A
  • Pustular

2 variants - Localized and Generalized (von Zumbusch)

  • Impetigo herpitformis (pregnancy)
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16
Q

GEneralized erythema without scaling

A

Eryhtroderma/ exfoliative dermatitis

17
Q

Types of Psoriasis accdg to location

A
  1. Scalp psoriasis
  2. Flexures/ intertriginous/ inverse
  3. palmoplantar
  4. Nail psoriasis
  5. Psoriatic arthritis
18
Q

Characteristics of Nail Psoriasis

A
  1. Onycholysis
  2. Oil spots
  3. Pitting
  4. Subungal hyperkeratosis
  5. Asssociated with psoriatic arthritis of DIP
19
Q

Sausage digit in psoriatic arthritis

A

Dactylitis

20
Q

Commonly on the Achilles endon bony attachment

A

Enthesitis

21
Q

Comorbidities of psoriasis (5)

A
  1. Depression
  2. Uveitis
  3. IBD

4 MEtabolic syndrome (dys,hpn,ab obesity, diabetis mellitus)

  1. CVD => MI => Infarction
22
Q

1 blocks inflammatory mediators

2 Inhibits keratinocytes

  1. allows more UV light to interact with hyperproliferative
A
  1. Steroids
  2. Calcipotriol and anthralin
  3. Tar
23
Q

UV phototherapy

A
  1. UVB, PUVA, (psoralen + UVA)
24
Q

Systemic drugs

A

Methotrexate, cyclosporine, acitretin

Dermatology Module (13 decks)

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