PSORIASIS

Question 1

PICTURES

Answer 1

PICTURES

Question 2

the best characterized T cells are the __ cells

Answer 2

CD4+ and
CD8+ T

Question 3

__ predominantly located in the epidermis,
whereas __ cells are predominantly located in the upper dermis

Answer 3

o CD8+  EPIDERMIS
o CD4+  UPPER DERMIS

Question 4

Two other sub-sets of CD4+ T cells, stimulated by IL-23
and characterized by production of IL-17 (Th17 cells) and/or IL-22 (Th22 cells), are also found in psoriatic lesions and have been shown to play a major role in maintaining chronic inflammation in psoriasis

Answer 4

-_-

Question 5

major producers of IFN-
γ and serve as a bridge between innate and acquired immunity

Answer 5

Natural Killer Cells, NK cells

Question 6

SIGNALING MOLECULES IN PSORIASIS

Answer 6

Cytokines and Chemokines

Question 7

The complement component __ is a potent chemoattractant for neutrophils and may
contribute to the accumulation of neutrophils in the stratum
corneum of psoriasis.

Answer 7

C5a

Question 8

Clinical findings/ history for psoriasis:

Answer 8

1. Age of onset
2. Presence/absence of family history of psoriasis

Question 9

Acute is how many weeks?

Answer 9

<6 weeks

Question 10

if you are going to peel off the scale you will have a pinpoint bleeding underneath the scale

Answer 10

Au spitz sign

Question 11

ISOMORPHIC RESPONSE

Answer 11

KOEBNER PHENOMENON

Question 12

is the traumatic induction of psoriasis on non-lesional skin; it occurs more frequently during fares of disease and is all or none phenomenon

Answer 12

KOEBNER PHENOMENON( ISOMORPHIC RESPONSE)

Question 13

The classic lesion of psoriasis is a __

Answer 13

well-demarcated,
raised,
red plaque with a
white scaly surface

Question 14

The Koebner reaction usually occurs __ days after injury

Answer 14

7-14 days /
1-2 weeks

Maximum of 2 weeks after you have inflicted the trauma

Question 15

CLINICAL PATTERNS OF SKIN PRESENTATION/
PSORIASIS IS AKA.

Answer 15

Psoriasis Vulgaris,
Chronic Stationary Psoriasis,
Plaques-Type Psoriasis

Question 16

the most common form of
psoriasis, seen in approximately 90% of patients

Answer 16

Psoriasis vulgaris

Question 17

Single small lesion may become confluent, forming
plaques in which the borders resemble a land map

Answer 17

psoriasis geographica

Question 18

Lesions may extend laterally and become circinate because of the confluence of several plaques

Answer 18

psoriasis gyrate

Question 19

Occasionally, there is partial central clearing, resulting in ring-like lesion

Answer 19

annular psoriasis

Question 20

Resembles guttate psoriasis clinically but can be distinguished by its onset in older patients

Answer 20

SMALL PLAQUES PSORIASIS

Question 21

Psoriasis lesions may be localized in the major skin folds, such as the axilla and genito-crural region, and the neck.

Answer 21

INVERSE (FLEXURAL) PSORIASIS

Question 22

PICTURES

Answer 22

PICTURES

Question 23

represents the generalized form of the disease that affects all body sites, including the face, hands, feet, nails, trunk and extremities

Answer 23

ERYTHRODERMIC PSORIASIS

Question 24

clinical variants of pustular psoriasis

Answer 24

• Generalized pustular psoriasis (von Zumbusch type)
• Annular pustular psoriasis
• Impetigo herpetiformis

Question 25

variants of localized pustular psoriasis:

Answer 25

• Pustulosis palmaris et plantaris
• Acrodermatitis continua of Hallopeau

Question 26

“Oil drop sign” or “Salmon patch”

Answer 26

psoriasis physical findings

Question 27

MIGRATORY TONGUE AKA.

Answer 27

benign migratory glossitis or
glossitis areata migrans

Question 28

a common extracutaneous manifestation of psoriasis seen in up to 40% of patients

Answer 28

PSORIATIC ARTHRITIS

Question 29

Laboratory tests in psoriasis patients

Answer 29

• biopsy
• altered lipid profiles
  > cholesterol
  > sugar
  > creatinine

SERUM URIC ACID is elevated in up to 50% of patients

Question 30

Treatment that regulates skin cell production and
evelopment

Answer 30

Calcipotriene and betamethasone ointment

Question 31

MEDICATION SUMMARY OF PSORIASIS

Answer 31

• sunshine moisturizers,
  and salicylic acid

 Treatments for more advanced psoriasis include
 narrow-band ultraviolet B (UVB) light
 psoralen with ultraviolet A (UVA)
 retinoids (e.g., isotretinoin, acitretin)
 methotrexate
 cyclosporine
 Biologics:
 infliximab (Remicade)
 adalimumab (Humira)
 ustekinumab
 etanercept (Enbrel)
 alefacept (Amevive)
 Topical corticosteroids
 Keratolytic Agents
 salicylic acid
 lactic acid
 urea
 Anthralin
 Vitamin D Analogs
 Calcitriol ointment
 Calcipotriene
 Calcipotriene and betamethasone ointment
- regulates skin cell production and
evelopment