PSORIASIS Flashcards
defnition of psoriasis
Sharply demarcated erythematous plaques with micaceous scale
genes that cause psoriasis x2
HLA-Cw6
Psoriasis susceptibility regions PSORS1-9
what cells cause psoriasis
T cells which turn into
T helper 1, 17 &22
what does psoriasis do to the cell cycle
reduced from 28 days to 3-5
what does psoriasis do to nails
Onycholysis, pitting, oil spots
what age does glute psoriasis occur
children and adolescents
psoriasis on just hands and feet
Palmo-plantar Psoriasis, or pustulosis
what psoriasis tends to occur in flexures, has less scale
and is triggered by infections
Flexural / Inverse Psoriasis
what type of psoriasis has Sterile pustules, sometimes systemic symptoms
what causes it x4
Pustular Psoriasis
Pregnancy
or after rapid taper/stop steroids
hypocalcaemia
infection
what type of psoriasis causes:
more than 80% of body surface area in erythematous, with fine scale
fever and low blood pressure
treatments x3
Erythrodermic psoriasis- ‘Red Man’ syndrome
-FLUID BALANCE
-Bloods / IV access
-Thick greasy ointment emollients
primary care for psoriasis x6
Emollients, Creams vsOintments
Soap substitutes
Vitamin D3 analogues
Coal Tar creams
Topical Steroid
Salicylic acid (keratolytic)
secondary care for psoriasis x7
Crude Coal Tar
Dithranol
UVB Phototherapy
Oral retinoids- Acitretin
Immunosuppression: Methotrexate
Small Molecules
Biologic Therapies