PSORIASIS Flashcards

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1
Q

defnition of psoriasis

A

Sharply demarcated erythematous plaques with micaceous scale

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2
Q

genes that cause psoriasis x2

A

HLA-Cw6
Psoriasis susceptibility regions PSORS1-9

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3
Q

what cells cause psoriasis

A

T cells which turn into

T helper 1, 17 &22

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4
Q

what does psoriasis do to the cell cycle

A

reduced from 28 days to 3-5

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5
Q

what does psoriasis do to nails

A

Onycholysis, pitting, oil spots

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6
Q

what age does glute psoriasis occur

A

children and adolescents

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7
Q

psoriasis on just hands and feet

A

Palmo-plantar Psoriasis, or pustulosis

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8
Q

what psoriasis tends to occur in flexures, has less scale
and is triggered by infections

A

Flexural / Inverse Psoriasis

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9
Q

what type of psoriasis has Sterile pustules, sometimes systemic symptoms

what causes it x4

A

Pustular Psoriasis

Pregnancy
or after rapid taper/stop steroids
hypocalcaemia
infection

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10
Q

what type of psoriasis causes:
more than 80% of body surface area in erythematous, with fine scale
fever and low blood pressure

treatments x3

A

Erythrodermic psoriasis- ‘Red Man’ syndrome

-FLUID BALANCE
-Bloods / IV access
-Thick greasy ointment emollients

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11
Q

primary care for psoriasis x6

A

Emollients, Creams vsOintments
Soap substitutes
Vitamin D3 analogues
Coal Tar creams
Topical Steroid
Salicylic acid (keratolytic)

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12
Q

secondary care for psoriasis x7

A

Crude Coal Tar
Dithranol
UVB Phototherapy
Oral retinoids- Acitretin

Immunosuppression: Methotrexate
Small Molecules
Biologic Therapies

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