PSA study

Question 1

what are common P450 enzyme inducers? PC BRAS

Answer 1

phenytoin, carbamazepine, barbiturates, rifampicin, alcohol (chronic excess), Sulphonylureas

Question 2

what are common P450 enzyme inhibitors?

Answer 2

Allopurinol, omeprazole, disulfiram, erythromycin, valproate, isoniazid, ciprofloxacin, ethanol (acute intoxication), sulphonamides

Question 3

which medication should be increased during surgery?

Answer 3

steroids if patient on long-term, similar to sick day rules

Question 4

what drugs should be stopped before surgery? (I LACK OP)

Answer 4

insulin, lithium, anticoag/antiplatelets, COCP/HRT, K-sparing diuretics, Oral hypoglycaemics, perindopril (and other ACEis)

Question 5

when should a patient stop taking their COCP or HRT before surgery?

Answer 5

4 weeks before surgery

Question 6

when should a patient stop taking their lithium before surgery?

Answer 6

one day before

Question 7

when should a patient stop taking their potassium sparing diuretic or ACEi?

Answer 7

the day of surgery