PRRs

Question 1

TLR1/2

Answer 1

LTA, Lipoproteins . MyD88 and NFkB

Question 2

TLR2/6

Answer 2

LTA, lipopeptides. MyD88 and NFkB

Question 3

TLR3

Answer 3

dsRNA. Endsomal TRIF -> IRF ( leads to IFN).

Question 4

TLR4

Answer 4

LPS, MyD88 and TRIF

Question 5

TLR5

Answer 5

Flagellin, MyD88

Question 6

TLR 7

Answer 6

ssRNA, Endosomal, MyD88

Question 7

TLR 8

Answer 7

ssRNA, endosomal, MyD88

Question 8

TLR 9

Answer 8

CpG DNA, endosomal, MyD88

Question 9

How to TLRs signal?

Answer 9

They contain TIR domains (Toll/IL-1 homology domains). These are on the cytoplasmic side. Once two TLRs bind a ligand, they will dimerize. This dimerization is either homo or heterodimerization.

Question 10

What do NLRs recognize?

Answer 10

Peptidylglycans

Question 11

What do Rig-I and Rig like receptors recognize?

Answer 11

Viral dsRNA

Question 12

What are three cytosolic DNA sensors?

Answer 12

Aim2, Sting, cGas.

Question 13

What receptors on cells recognize bacterial proteins?

Answer 13

N-formyl receptors

Question 14

How does complement function in innate immunity?

Answer 14

Bacterial componet