Effector CD4 T cells Flashcards
What cytokines do Th17 cells produce?
IL-17 and IL-22
What role do Th2 cells play?
They are able to control infections of extracellular parasites by promoting B cell class switching to IgE. They are able to activate cytokines via the cytokines they produce.
What is the major Tf guiding Th1 cell development?
T-bet
What role do Th17 cells play?
They are important for extracellular bacteria and fungi. They enhance neutrophil activity, promote B cells to produce IgG, and IL-17 and 22 enhance barrier function of the epithelia.
What role do Tfh cells play?
They promote germinal center responses in the lymph nodes.
What are the face specifying cytokines to make Th2
IL-4
What cytokines do Th1 cells produce?
They produce IFN-gamma, IL2
What is the major Tf guiding Th2 cell development
GATA-3
What cytokines do Th2 cells produce?
IL-4, IL-5, IL-13
What role do Th1 cells play?
By producing IFN-gamma, they are able to able to activate macrophages. This increase macrophages killing capacity to phagocytosed pathogens. They also promote B cell production for IgG
What are the fate specifying cytokines to make Th1 cells?
IFN-gamma and IL-12
What are the fate specifying cytokines to make Th17
IL-6, TGF-B, IL-23, IL-1
What is the major Tf guiding Th17 cell development?
RoryT
What role do Tregs play?
They suppress the immune response. TGF-b and IL-10
