Protozoans Flashcards
that branch of medical sciences that deals with parasites that cause or transmit disease to man.
Medical Parasitology:
organisms that live in or on a host deriving food and shelter and causing harm to that host.
Parasites:
“Any two organisms living in close association, commonly one living in or on the body of the other,
Symbiosis
One partner benefits but the other is not hurt.
Commensalism:
Both partners benefit.
Mutualism:
One partner harms or lives on the expense of the other
Parasitism:
live within the host causing infection.
Endoparasites:
live on the external surface of the host causing infestation.
Ectoparasites:
only visits the host to get its meal.
Temporary parasite:
always fixed to the host.
Permanent parasite:
produces disease only in immunodeficient hosts.
Opportunistic parasite:
When an organism can live free or establishes a parasitic existence depending on a host.
Facultative Parasitism
When an organism establishes a permanent parasitic existence and is completely dependent on the host.
Obligatory parasitism:
occasionally an organism parasitizes a species other than its usual host.
Accidental or incidental parasitism:
They infect host where they cannot live or develop further.
Abberant or wandering parasite:
in which the adult or sexually reproducing form of the parasite lives.
Definitive host
in which the parasite lives during its larval stage or asexually reproducing form.
Intermediate host:
an animal harboring the same stage of the parasite like in human and represent a potential source of infection to man.
Reservoir host:
“usually an arthropod”: transmits parasites from infected organisms to other hosts.
Vector
Habitat
Small intestine
Large intestine
Blood vessels
Organs; liver, lung, heart, brain,
Muscles
Lymphatics
Reticuloendothelial system
Cells as red blood cells
Transmission Source
Water
Soil
Raw vegetables & fruits
Animals
Fish
Vector [Arthropods]
Blood
Transmission Mode of infection
Ingestion (Oro-fecal)
Inhalation
Penetration of skin & mucous membrane
Bite of vector (vertical transmission)
Direct contact
Congenital transmission
Blood transfusion
Sexual
Trans-mamary
Parasitic toxic products:
produce allergy or necrosis.
Anaemia:
Malarial parasite & Ancylostoma.
Mechanical obstruction:
Ascaris.
Mechanical pressure:
Hydatid cyst.
Abortion or Congenital anomalies:
T. gondii.
PROTOZOANS TRANSMISSION:
mostly from one host to another within
PROTOZOANS PATHOGENESIS:
Attachment to host followed by replication
Shifting of antigen expression to evade immune response of host defences.
PROTOZOANS Antiprotozoal Agents:
Agents target the Nucleic Acid synthesis protein
Synthesis or specific metabolic pathway unique to the protozoan parasites:
Entamoeba histolytica stage
Trophozoites
Cyst
Entamoeba histolytica -Lab diagnosis:
stool for cyst stage
stool for cyst stage color and reagent
Reddish brown with iodine
Giardia lamblia diesease
GIARDIASIS
GIARDIASIS Ingestion of csyt- _________ stimulates Excystation
Gastric acid
GIARDIASIS Release of Trophozoites in
duodenum and jejunum
GIARDIASIS transmission
Oro fecal
Person to person
Uncooked produce
GIARDIASIS Immunity:
IgA
Trichomonas vaginalis disease
TRICHOMONIASIS
TRICHOMONIASIS transmission
Sexual
Fomites
Birth Canal
TRICHOMONIASIS percentage
5-20 in women
2-10 in men
Trichomoniasis lab
Urine sediments
Secretion (vaginal and prostatic)
Leishmania Species stage
Amastogote (Aflagellar)
Promastigote (Flagellated)
Leishmania Species vector
Sand flies
Sand flies spp
(Phlebotomus and Lutzomyia)
Leishmania Species Natural habitat in man:
Reticuloendothelial system
Leishmania Species reproduction
Binary fission
Leishmania Species disease
KALA-AZAR
(black sickness)
(dumdum fever)
Leishmania Species lab
tissue biopsy,
Spleen, bone marrow, lymph
node aspiration (Giemsa Stain)
Serologic testing
Leishmania Species Pathogenesis:
-Reduced bone marrow activity
Leishmania Species spleen damage leads to
anemia
thrombocytopenia
leukopenia
VISCERAL LEISHMANIASIS
Leishmania donovani
CUTANEOUS LEISHMANIASIS
Leishmania tropica
MUCOCUTANEOUS LEISHMANIASIS
Leishmania braziliensis
Trypanosoma disease
TRYPANOSOMIASIS
Trypanosoma brucei disease
Sleeping sickness
(African Trypanosomiasis)
Trypanosoma brucei stage of life
Amastigote:
Promastigote:
Trypomastigote
elongated and spindle shape body
Trypomastigote:
Trypanosoma brucei vector
Tsetse fly
Tse tse fly habitat
shaded stream banks
Cattle raising countries-domestic animal host
Gambian sleeping sickness:
Winterbottoms sign
Trypanosoma brucei Lab
Anticoagulated blood preparation exam
Trypanosoma cruzi disease
Chagas disease
(American Tripanosomiasis)
Trypanosoma cruzi vector
reduviid bugs
Erythematous and endurated area
chagoma