protooncogenes /tumor suppressor

Question 1

ALK

Answer 1

Receptor tyrosine Kinase

Lung Adenocarcinoma (Adenocarcinoma of the Lung Kinase

Oncogenes

Question 2

BCR-ABL

Answer 2

Non-receptor tyrosine kinase

CML,ALL

Oncogenes

Question 3

BCL-2

Answer 3

Antiapoptotic molecule (inhibits apoptosis
Follicular and diffuse large B Cell Lymphomas
Oncogenes

Question 4

BRAF

Answer 4

Serine/threonine kinase
Melanoma, non hodgkin lymphoma, papillary thyroid carcinoma, hairy cell leukemia
Oncogenes

Question 5

c-K/T

Answer 5

CytoKlne receptor
Gastrointestinal stromal tumor (GIST
Oncogenes

Question 6

c-MYC

Answer 6

Transcription factor
Burkitt lymphoma
Oncogenes

Question 7

HER2/neu (c-erb82

Answer 7

Receptor tyrosine kinase
Breast and gastric carcinomas
Oncogenes

Question 8

JAK2

Answer 8

Tyrosine kinase
Chronic myeloproliferative disorders
Oncogenes

Question 9

KRAS

Answer 9

GTPase
Colon cancer, lung cancer, pancreatic cancer
Oncogenes

Question 10

MYCL1

Answer 10

Transcription factor
Lung tumor
Oncogenes

Question 11

N-myc (MYCN)

Answer 11

Transcription factor
Neuroblastoma
Oncogenes

Question 12

RET

Answer 12

Receptor tyrosine kinase
MEN 2A and ZB, papillary thyroid carcinoma
Oncogenes

Question 13

WT1

Answer 13

Transcription factor that regulates urogenital development

Wilms tumor (nephroblastoma)

Question 14

VHL

Answer 14

Inhibits hypoxia-inducible factor la

von Ilippel-Lindau disease

Question 15

TSC2

Answer 15

Tuberin protein

Tuberous sclerosis

Question 16

TSC1

Answer 16

Hamartin protein

Tuberous sclerosis

Question 17

TP53

Answer 17

p53, activates p21, blocks C 1 - S phase

Most human cancers, Li-Fraumeni syndrome (multiple malignancies at early age, aka, SBLA cancer syndrome: Sarcoma, Breast, Leukemia, Adrenal gland)

Question 18

Rb

Answer 18

Inhibits E2 F; blocks C1 - S phase

Retinoblastoma, osteosarcoma (bone cancer)

Question 19

PTEN

Answer 19

Negative regulator of PJ3k/AKT pathway

Breast, prostate, and endometrial cancer

Question 20

NF2

Answer 20

Merlin (schwannomin) protein

Neurofibromatosis type 2

Question 21

NF1

Answer 21

Neurofibromin (Ras GTPase activating protein

Question 22

MEN1

Answer 22

menin

Question 23

SMAD 4(DPC4)

Answer 23

deleted in pancreatic cancer

Question 24

DCC

Answer 24

deleted in colon cancer

Question 25

CDKN2A

Answer 25

p16, blocks G1-->s phase me;anoma, pancreatic cancer

Question 26

BRCA1/BRCA2

Answer 26

DNA repair | Breast ovarian and pancreatic

Question 27

APC

Answer 27

Negative regulator of bcatenin/WNT pathway Colorectal cancer (associated with FAP