Proteolysis and Blood Coagulation

Question 1

What are the three ways clotting is regulated?

Answer 1

Factors are diluted by blood, liver takes out active factors, factors degrade by proteases (negative feedback of kvllikrein on 12 and thrombin activating antithrombin and Protein C).

Question 2

What are the three roles of platelets?

Answer 2

surface for clotting factors (flip inner leaflet), provide clotting factors, aggregate to block area

Question 3

What proteins are activated by proteolysis?

Answer 3

CBPD

collagen, blood clotting factors, protein hormones, digestive enzymes

Question 4

What are the four properties of proteolytic activation?

Answer 4

allows enzymes to be circulating inactive, irreversible, have to inactivated by antiproteases, rapid activation to site of action

Question 5

Riveraxaban

Answer 5

anti factor 10

Question 6

Warfarin

Answer 6

inhibits vitamin K recycling into active form, inhibiting vitamin K dependent factors 2, 7, 9, 10

Question 7

Aspirin

Answer 7

Factor 13 inhibitor

Question 8

Clopidogrel

Answer 8

inhibits platelets

Question 9

Dobigotren

Answer 9

competitive inhibitor thrombin

Question 10

Heparin

Answer 10

activates antithrombin

Question 11

Antithrombin inhibits

Answer 11

Factors 9-12

Question 12

Which factors activate 7?

Answer 12

12, 9, and 10

Question 13

When does kallikrein inhibit Factor 12?

Answer 13

When 12 is all 12a , kallikrein binds to another active site to take 12 to 12f.

Question 14

Trypsin has been accidentally activated in the pancreas. . How does the pancreas protect itself?

Answer 14

PTI (pancreatic trypsin inhibitor). Binds competitively to the trypsin active site. Inflexibly binding into a complex that is later digested. This complex is inactive.