Proteins: Tertiary and Quaternary Structure

Question 1

Can proteins (alpha helices and beta pleated sheets) twist and turn to form a 3D structured protein?

Answer 1

YES

Question 2

How is the 3D structure held together?

Answer 2

By different bonds between R groups

Question 3

____________ form between polar R groups

Answer 3

Hydrogen
Polar

Question 4

ionic bonds form between ________ and _______ R groups

Answer 4

Positive
Negative

Question 5

Where do Disulphide links form ?

Answer 5

forms between any R groups having sulfur in them

Question 6

Do disulfide links happen in proteins only? Or in lipids and carbs too?

Answer 6

In proteins only.

Question 7

What are the 3 types of links happening to form a 3D structure in proteins?

Answer 7

• Disulfide links
• Hydrogen bonds
• Ionic bonds

Question 8

The specific 3D protein structure is also determined by the ___________ and ___________ R groups.

Answer 8

Hydrophilic
Hydrophobic

Question 9

Which amino acids are tend to be found in the centre of the protein?

Answer 9

The amino acids with Hydrophobic R groups

Question 10

Which amino acids are tend to be found in the periphery
of the protein and point outwards?

Answer 10

Amino acids with Hydrophillic R groups

Question 11

Definition of Tertiary structure

Answer 11

The overall specific 3D shape of a protein
which is determined by interaction
between R groups
and properties of R groups.

Question 12

can proteins be made of more than one polypeptide chain?

Answer 12

Yes, they can be made of either only one polypeptide chain, or made up of many polypeptide chains.

Question 13

How are polypeptide chains held together in 3D structure ?

Answer 13

Through…
- Hydrogen bonds
- Disulfide links
- Ionic bonds

Question 14

What is the name of the non-protein group that is associated with the polypeptide chains sometimes? When associating polypeptides with these groups, what is the name of the final structure?

Answer 14

Prosthetic group
Conjugated protein

Question 15

bonding of different chains and prosthetic groups results in formation of proteins with a unique ________________

Answer 15

quaternary structure

Question 16

Definition of Quaternary structure of a PROTEIN

Answer 16

Specific 3D shape of a protein
Determined by the multiple polypeptide chains and/ or the prosthetic groups bonded together

Question 17

Importance of protein primary structure

Answer 17

It is what gives proteins their secondary, Tertiary and Quaternary structures and results in formation of unique proteins

Question 18

Imporatnce of difference in protein structure

Answer 18

This difference in structures allows proteins to carry out different functions and roles.

Question 19

Can the bonds maintaining protein structures be broken down?

Answer 19

Yes by changes in pH or temperature

Question 20

Change in the bonds causes the protein to change ________ and therefore cannot carry out its ___________ and the protein is __________

Answer 20

shape
function
denatured