proteins lec 3 Flashcards
Beta sheets are either ____ or ____. Their side chains point ____.
parallel
anti parallel
up and down
_____ tend to be flexible
beta sheets
Alzheimer’s disease, Huntington’s disease, prion disease
eg mad cow’s These diseases AKA _____
Amyloid diseases
what type of diseases have beta sheet structures
Amyloid diseases
What happens to the structure of proteins in Amyloid diseases? Explain properties as well..
The normal protein becomes misfolded
The molecules aggregate into large groups that accumulate in the body
native protein fold is stable/unstable etc?
very stable
what may happen to the native protein fold state?
It may move to fibril state by energy input ( to unfold)
what are prions?
misfolded and infectious proteins that interact with normal proteins causing them to misfold
silk aka ____ structure?
fibroin
layered beta sheets of glysine and alanine/serine layers
interdigitation ?
formation of layers by slotting amino acid rows into each other
spider silk aka___ made of?
spidroin
a mixture of betasheet nano crystalline regions and amorphous regions (like kevlar)
short 4 stranded beta sheets (hydrogen pattern most strongest, any more sheets = less strong)
no. of stranded beta sheets of spidroin for the strongest ?
4
6 beta sheets of spidroin is >, < or = to 4 beta sheets
6<4
more than 4 = less strong
high tensile strength and high plasticity is found in what?
spider silk
spidroin
Cross Beta structure formation overview.
native protein >
unfolded protein >
misfolded protein + cross Beta-structure >
ogliomeres - amphorous aggregates . or protofibrils >fibrils
