Proteins as Drug Targets Ch 2 Flashcards
1
Q
Primary structure
A
Order of amino acids
2
Q
Peptide bond property
A
Planar amide bond
3
Q
Secondary structure
A
Local folding (alpha helix, beta sheet, and beta turns)
4
Q
Tertiary structure
A
Overall 3-D shape of protein as a result of hydrophobic forces and covalant bonds (disulfide bridges).
5
Q
Quaternary structure
A
How individual polypeptide chains (subunits) associate.
6
Q
Post-translational modification
A
Phosphorylation, glycosylation, and amino acid modification that occurs after the biosynthesis of protein.
7
Q
Translation
A
Process by which protein is biosynthesized
8
Q
Proteonomics
A
Identification of all the proteins in the cell
9
Q
Monoclonal antibodies (2 examples)
A
Can be chimeric (from mice) or fully humanized. They are not proteolyzed quickly in the body. Ex. Herceptin, Avastin.
