Ch. 15 Combinatorial Flashcards
1
Q
What is combinatorial chemistry?
A
Used to prepare sets of compounds from sets of building blocks.
2
Q
Advantages of solid phase (5).
A
Product is immobolized.
Simple filtration for isolation.
Beads easy to manipulate (divide easily).
No side products.
Automation.
3
Q
Disadvantage of solid phase (4).
A
Hard to monitor.
Inefficient (need excess reagent).
Most reactions developed for solution phase.
Need design of linker molecules
4
Q
Advantages of solution phase (5).
A
Easy to monitor.
Scalable.
Little development time needed.
Stoichiometric reagents.
Automation.
5
Q
Disadvantage of solution phase.
A
Purification.
Automation difficult!
