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Biochemistry > Proteins > Flashcards

Proteins Flashcards

1
Q

All amino acids participate in transamination except

A

Lysine

Threonine

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2
Q

Most common porphyria

A

Porphyria cutanea tarda

Uroporphyrinogen decarboxylase

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3
Q

Ketogenic amino acids

A

Leucine

Lysine

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4
Q

Essential amino acids

A

Phe Val Trp Thr Ile Met His Arg Leu Lys

histamine and arginine can be non-essential

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5
Q

Sequencing: N terminal

Sanger

A

dinitrobenzene

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6
Q

Sequencing: N terminal

Edman

A

Phenylisothiocyanate

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7
Q

Sequencing: C terminal

A

Hydrazine, carboxypeptidase

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8
Q

Glycoproteins: O-linked

A

serine, threonine

hydroxyl group

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9
Q

Glycoproteins: N-linked

A

Asparagine

Amide group

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10
Q

Amino acid that carries nitrogen from peripheral tissues to liver

A

alanine

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11
Q

Amoino acid with largest side chain

A

tryptophan

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12
Q

Oxygen affinities of taut and relaxed forms

A

taut form - low affinity

relaxed form - high affinity

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13
Q

true or false: oxyhemoglobin has a high affinity for protons

A

DEoxyhemoglobin has a high affinity for protons

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14
Q

chocolate brown vs cherry pink blood

A

chocolate brown - metHb

cherry pink - carboxyHb

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15
Q

sickle cell anemia

A

glutamate –> valine at 6th position

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16
Q

hemoglobin C

A

glutamate –> lysine at 6th position

17
Q

Ehler-Danlos syndrome

A

type III collagen

18
Q

true or false: hydroxyproline and hyrdoxylysine are abundant in elastin

A

false

19
Q

true or false: elastin contains carbohydrates

A

false

20
Q

true or false: oxidative deamination occurs in all cells of the body

A

only in liver and kidneys

21
Q

cofactor for transamination

A

pyridoxal phosphate

22
Q

deamination of glutamate

A

glutamate dehydrogenase

23
Q

deamination of glutamine

A

glutaminase

24
Q

true or false: deamination of glutamine occurs in kidney and small intestine

A

glutaminase is present in kidney and small intestine

25
Q

true or false: transamination liberates ammonia

A

false

26
Q

Rate-limiting step in urea cycle

A

CO2+NH3–>carbamoyl phosphate [carbamoyl phosphate synthase I]

27
Q

Ketogenic and glucogenic amino acids

A

phenylalanine, tyrosine, tryptophan, isoleucine

28
Q

true or false: 2,3-BPG binds to oxyhemoglobin

A

DEoxyhemoglobin

29
Q

Porphyria cutanea tarda

A

uroporphyrinogen decarboxylase: uropophyrinogen III–>coprophyrinogen III

30
Q

true or false: ZP3, the glycoprotein in zona pellucida is N-linked

A

O-linked

31
Q

true or false: methionine synthase requires B6

A

B12

32
Q

true or false: tetrahydrofolate reductase requires B12

A

B2

Biochemistry (11 decks)

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