Lipids

Question 1

Linoleic acid

Answer 1

18:2 (9,12)

Question 2

Linolenic acid

Answer 2

18:3 (9,12,15)

Question 3

Arachidonic acid

Answer 3

20:4 (5, 8, 11, 14)

Question 4

Sudden infant death syndrome

Answer 4

Medium chain fatty acyl CoA dehydrogenase

Question 5

Refsum’s disease

Answer 5

pythanic acid

Question 6

Levels of this HDL inversely proportional to the incidence of coronary atherosclerosis

Answer 6

HDL 2

Question 7

Carnitine palmitoyl transferase I deficicency

Answer 7

Liver

Hypoglycemia

Question 8

Carnitine palmitoyl transferase II deficicency

Answer 8

Cardiac and skeletal muscle

Cardiomyopathy
Muscle weakness
Myloglobinuria

Question 9

Steps in beta-oxidation

Answer 9

Oxidation
HydrATION
Oxidation
Thiolysis

Question 10

Apolipoproteins: activates LCAT

Answer 10

A-I

Question 11

Apolipoproteins: cofactor for lipoprotein lipase

Answer 11

C-II

Question 12

Apolipoproteins: chylomicron assembly and secrtion

Answer 12

B-48

Question 13

Apolipoproteins: mediates uptake of chylomicron remains

Answer 13

E

Question 14

True or false: adipose tissue is a major site of lipogenesis

Answer 14

false

Question 15

Rate limiting step: lipogenesis

Answer 15

acetyl-CoA–>malonyl-CoA [acetyl-CoA carboxylase]

Question 16

steps in lipgenesis

Answer 16

Condensation
Reduction
Dehydration
Reduction

Question 17

Essential fatty acids: body cannot create double bonds beyond __ carbon

Answer 17

C-9

Question 18

Rate-limiting step in beta-oxidation

Answer 18

fatty-acyl CoA + carnitine –> fatty-acyl carnitine + CoA [carnitine acetyltransferase]

Question 19

oxidation of odd-number fatty acids require

Answer 19

Vitamin B12

Question 20

True or false: Liver converts acetoacetate to acetyl CoA

Answer 20

False. Liver does not have succinyl-CoA acetoacetyl-CoA transferase.

Question 21

Which ketone body is not detected by nitroprusside test?

Answer 21

beta-hydroxybutyrate

Question 22

Cholesterol is composed of _ hydrocarbon rings with _ membered side chain attached to _ ring

Answer 22

4 hydrocarbon rings with 8-membered side chain attached to D ring

Question 23

The rate-limiting step in cholesterol synthesis produces what?

Answer 23

mevalonate

Question 24

apoprotein secreted by intestinal epithelial cell

Answer 24

B-48

Question 25

apoprotein secreted by liver

Answer 25

B-100

Question 26

binds to LDL and VLDL receptors

Answer 26

B-100

Question 27

Lipid disease associated with increased risk of atherosclerosis and CHD

Answer 27

Type II: familial hypercholesterolemia

deficiency in LDL receptors

Question 28

Deficience of apo B48 and 100

Answer 28

Abetalipoproteinemia
(-) chylomicron, (-) VLDL/HDL
intestinal malabsorption, accumulation of lipids in intestine and liver

Question 29

Most abundant phospholipid

Answer 29

phosphatidylcholine

Question 30

Major lipid component of lung surfactant

Answer 30

dipalmitoylphosphatidylcholine

Question 31

Glycolipid: fatty acid

Answer 31

ceramide

Question 32

Glycolipid: glucose or galactose

Answer 32

cerebroside

Question 33

Glycolipid: oligosaccharide

Answer 33

globoside

Question 34

Glycolipid: N-acetylneuramic acid

Answer 34

ganglioside

Question 35

Glycolipid: sulfated galactose

Answer 35

sulfatides

Question 36

defect in carnintine acyl transferase I–>elevated

Answer 36

carnitine

Question 37

defect in carnintine acyl transferase II–>elevated

Answer 37

acyl carnitine

Question 38

moles of ATP per 1 mole of acetyl CoA

Answer 38

10

Question 39

true or false: fatty acid synthesis occurs in the mitochondria

Answer 39

cytoplasm

Question 40

true or false: acetyl-CoA oxidation occurs in cytoplasm

Answer 40

mitochondria

Question 41

true or false: very long chain fatty acids are oxidized in the mitochondria

Answer 41

peroxisome