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Proteins Flashcards

1
Q

A protein structure with local folding

A

Secondary struture

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2
Q

A protein structure that has a 3D shape

A

Tertiary

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3
Q

Protein structure held together with subunits

A

Quaternary

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4
Q

Plasma proteins are synthsized in the

A

Liver

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5
Q

2 proteins not synthesized by the liver

A

VWF and Immunoglobulins

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6
Q

VWF is produced by the ___

A

endothelial cells, megakaryocytes

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7
Q

Immunoglobulins are produced by the ____

A

plasma cells

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8
Q

The nitrogen content of serum proteins

A

16%

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9
Q

Other name for Prealbumin

A

Transthyretin

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10
Q

The most anodal protein

A

Pre-albumin

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11
Q

A protein that transports thyroid hormones and Vit. A by forming a retinol binding complex

A

Pre-albumin

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12
Q

A protein marker for malnutrition

A

Pre-albumin

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13
Q

Protein that has the highest concentration in serum

A

Albumin

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14
Q

Concentration of Albumin in Total Protein

A

2/3

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15
Q

Provides 80% COP in the body, prevents edema

A

Albumin

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16
Q

Hypoalbuminemia causes what condition?

A

Edema

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17
Q

Increased Albumin means

A

Dehydration

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18
Q

Ratio of Globulin in Total Protein

A

1/3

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19
Q

Inhibits Protease: Elastin

A

A1-antitrypsin

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20
Q

AAT Deficiency causes

A

Emphysema

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21
Q

Hormone that helps in the prevention of Emphysema

A

Elastin

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22
Q

A COPD, “Pink puffer’

A

Emphysema

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23
Q

“Barrel Chest”

A

Emphysema

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24
Q

Blue Bloaters

A

Chronic Bronchitis

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25
Synthesized in the fetal liver for the protection of fetus against an immunologic attack from the mother
A1-fetoprotein
26
Low AFP means
Down Sytndrome
27
High AFP means
Neural tube defect, Spina Bifida
28
AFP is a tumor maker for
Hepatocellular carcinoma & Testicular Carcinoma
29
Protein that transports Copper
Ceruloplasmin
30
Protein associated with Wilson's Disease
Ceruloplasmin
31
Increased copper in liver results in
hepatic cirrhosis
32
Increased copper in the brain results in
Neurologic damage
33
Increased copper in the cornea
Kayser-Fleischer rings
34
Wilson's Disease Lab test results
Total Serum Copper: Low Free & Urinary Copper: High
35
Protein that inhibits Trypsin, Thrombin, Plasmin, Kallikrein
A2-macroglobulin
36
A2-Macroglobulin is increased in what syndrome?
Nephrotic Syndrome
37
Hypoalbuminemia, Hypogammaglobulinemia, Hypercoagulable state, Hyplerlipidemia are manifestations of what syndrome?
Nephrotic Syndrome
38
Glomerulus can filter out substances with only _______ daltons
70,000 kDa
39
Protein that binds free hemoglobin
Haptoglobin
40
2 Proteins decreased in Hemolytic Anemia
Haptoglobin & Hemopexin
41
Protein that scavenge heme to protect the body from oxidative damage
Hemopexin
42
Protein that transports ferric substances
Transferrin
43
Protein that can determine the cause of IDA
Transferrin
44
A protein, opsonin, and suggests and inflammation
CRP
45
DETERMINES the risk for Cardiovascular disease
hsCRP
46
A placental glue
Fibronectin
47
Used to test for the assessment of the risk for Preterm Delivery (24-35 gestational age)
Fibronectin
48
MArker for Bone Resorption
CL-C-Telopeptide
49
Gold standard for MI
Troponin
50
3 subunits of Troponin
Trop T, Trop I, Trop C
51
1st protein marker to increase during MI
Myoglobin
52
1st to increase during MI, but non-specific
Myoglobin
53
Protein marker for Congestive Heart Failure
BNP/N terminal BNP
54
MI Markers
Myoglobin Troponin CK-MB AST LD
55
Give the a2 globulins
C H A Ceruloplasmin Haptoglobin A2 macroglobulin
56
Gamma Globulins
IgA IgG IgM IgD IgE CRP
57
CRP increases
1000x
58
Serum Amylois A increases
1000x
59
AAT increases
2-5x
60
Fibrinogen increases
2-5x
61
Haptoglobin increases
2-10x
62
Ceruloplasmin increases
2x
63
C3 increases
2x
64
Mannose-Binding Protein increases
?
65
CRP concentration
0.5 mg/dL
66
Serum Amyloid A conc.
3 mg/dL
67
AAT conc.
200-400 mg/dL
68
Fibrinogen conc.
110-400 mg/dL
69
Haptoglobin conc.
40-200 mg/dL
70
Ceruloplasmin conc.
20-40 mg/dL
71
C3 conc.
60-140 mg/dL
72
MBP conc.
0.15-1 mg/dL
73
Hyperproteinemia is a result of
dehydration
74
Reference method for Total protein
Kjelhadl method
75
Kjeldah; method measures what content?
Nitrogen 16%
76
Nitrogen content in protein
16% or 6.25 or 6.54
77
Routine Total Protein method
Biuret method
78
Buiret method produces what color?
Violet colored chelate
79
Total Protein method for research use
Dye-binding
80
Dye-binding Total protein method uses what reagent
BCG/BCP
81
Albumin measurement uses what method?
BCG and BCP
82
Beta-gamma bridging
Cirrhosis
83
Monoclonal spike
MM (IgG) Waldenstrom's macroglobulinemia (IgM)
84
High Beta
use of plasma instead of serum (fibrinogen)
85
Low AAT
Emphysema
86
Low Albumin, High A2 & Beta
NEphrotic Syndrome
87
The most significant finding in an electrophoretic pattern
Monoclonal Immunoglobulin Disease
88
5 Regions in Electrophoresis
Albumin A1 A2 Beta Gamma

Clinchem (12 decks)

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