Protein Synthesis Inhibitors (Tigecycline) Flashcards
What is the main glycycyline?
Tigecycline.
What is the mechanism of action of tigecycline?
Same as tetracyclines.
Tigecycline Antibacterial Spectrum
Broad-spectrum:
- MRSA.
- VRE.
- Anaerobes.
- Multi-drug resistant streptococci.
- Extended-spectrum beta-lactamase producing gram-negative bacteria.
Tigecycline is ineffective against…
Pseudomonas.
What are the bacterial resistance mechanisms to tigecycline?
Via efflux pumps.
Tigecycline was developed to…
Overcome tetracycline resistant organisms.
Tigecycline is administered…
IV.
Tigecycline has a ___ volume of distribution.
High.
Tigecycline has ___ plasma concentration.
Low.
Tigecycline is eliminated…
Fecally.
Tigecycline’s Adverse Side Effects
- Same as tetracyclines.
- Nausea and vomiting.
- Elevation of liver enzymes and serum creatinine.
Tigecycline reduces the clearance of…
Warfarin.
Tigecycline is used when…
Alternatives do not work.
