CH3 | Protein Synthesis Inhibitors (Linezolid) Flashcards
What class of antibiotics does Linezolid belong to?
Oxazolidinones.
What is the mechanism of action (MOA) of Linezolid?
It binds to bacterial 23S ribosomal RNA of the 50S subunit, inhibiting the formation of the 70S initiation complex.
Is Linezolid bacteriostatic or bactericidal?
Bacteriostatic (cidal on streptococci).
What types of bacteria is Linezolid effective against?
Resistant Gram-positive bacteria such as MRSA, VRE, and penicillin-resistant streptococci.
What is Linezolid an alternative treatment for?
Infections caused by VRE.
What is a resistance mechanism associated with Linezolid?
Reduced binding to the target site.
What are the routes of administration for Linezolid?
Oral and IV.
How does Linezolid distribute in the body?
It distributes widely throughout the body.
How is Linezolid metabolized?
Via oxidation to 2 inactive metabolites.
What are the excretion routes for Linezolid?
By renal and nonrenal routes.
What are some common adverse effects of Linezolid?
GI upset, nausea, vomiting, diarrhea, headache, and rash.
What serious blood condition can occur with Linezolid use?
Thrombocytopenia.
What type of activity does Linezolid have that can lead to serotonin syndrome?
Nonselective monoamine oxidase (MAO) activity.
What can trigger serotonin syndrome when taking Linezolid?
Large quantities of tyramine-containing foods, SSRIs, or MAO inhibitors.
Is the serotonin syndrome caused by Linezolid reversible?
Yes, it is reversible.
